IE42652L - Optically pure imidazole carboxylates - Google Patents
Optically pure imidazole carboxylatesInfo
- Publication number
- IE42652L IE42652L IE760482A IE48276A IE42652L IE 42652 L IE42652 L IE 42652L IE 760482 A IE760482 A IE 760482A IE 48276 A IE48276 A IE 48276A IE 42652 L IE42652 L IE 42652L
- Authority
- IE
- Ireland
- Prior art keywords
- optically active
- phenylethyl
- imidazole
- acid
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Optically active C1-C3-alkyl esters of 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid are prepared by reacting racemic 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid with an optically active isomer of 1-phenylethylamine, 1-(1-naphthyl)ethylamine or 1-(2-naphthyl)ethylamine. The resulting insoluble diastereomeric salt is separated off and treated with a strong non-oxidising mineral acid. The resulting optically active 1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid is then esterified with a C1-C3-alcohol. In another process, the resulting optically active acid is firstly converted into the acid halide and then correspondingly esterified. The prepared compounds can be used as hypnotics.
[GB1535566A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55719475A | 1975-03-10 | 1975-03-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE42652L true IE42652L (en) | 1976-09-10 |
| IE42652B1 IE42652B1 (en) | 1980-09-24 |
Family
ID=24224401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE482/76A IE42652B1 (en) | 1975-03-10 | 1976-03-09 | Method for the preparation of optically pure loweralkyl imidazole carboxylates |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS51115473A (en) |
| AT (1) | AT353262B (en) |
| AU (1) | AU503733B2 (en) |
| BE (1) | BE839120A (en) |
| BG (1) | BG24806A3 (en) |
| CA (1) | CA1066709A (en) |
| CH (1) | CH629192A5 (en) |
| CS (1) | CS203116B2 (en) |
| DE (1) | DE2609573A1 (en) |
| DK (1) | DK99376A (en) |
| ES (1) | ES445450A1 (en) |
| FI (1) | FI62292C (en) |
| FR (1) | FR2318159A1 (en) |
| GB (1) | GB1535566A (en) |
| HU (1) | HU172026B (en) |
| IE (1) | IE42652B1 (en) |
| IL (1) | IL49190A (en) |
| IT (1) | IT1057941B (en) |
| LU (1) | LU74503A1 (en) |
| NL (1) | NL7602444A (en) |
| NO (1) | NO144884C (en) |
| PL (1) | PL99926B1 (en) |
| PT (1) | PT64879B (en) |
| SE (1) | SE7601959L (en) |
| SU (1) | SU677656A3 (en) |
| YU (1) | YU60876A (en) |
| ZA (1) | ZA761427B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE871675A (en) * | 1977-12-02 | 1979-04-30 | Smithkline Corp | PROCESS FOR PREPARING DERIVATIVES OF IMIDAZOLE |
| JPS5671073A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | Imidazole derivative |
| JPS5671074A (en) | 1979-11-12 | 1981-06-13 | Takeda Chem Ind Ltd | 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative |
| JPS58157768A (en) * | 1982-03-16 | 1983-09-19 | Takeda Chem Ind Ltd | 4-chloro-2-phenylimidazole-5-acetic acid derivative |
| PL149675B1 (en) * | 1986-03-10 | 1990-03-31 | Method of obtaining novel derivatives of 1-methyl 1h-imidazolecarboxylic-5 acid | |
| JP5580287B2 (en) * | 2008-03-31 | 2014-08-27 | ザ ジェネラル ホスピタル コーポレイション | Etomidate analogs with improved pharmacokinetic and pharmacodynamic properties |
| ES2617536T3 (en) | 2012-01-13 | 2017-06-19 | The General Hospital Corporation | Anesthetic compounds and related methods of use |
-
1976
- 1976-02-13 CA CA245,697A patent/CA1066709A/en not_active Expired
- 1976-02-18 GB GB6339/76A patent/GB1535566A/en not_active Expired
- 1976-02-19 SE SE7601959A patent/SE7601959L/en not_active Application Discontinuation
- 1976-02-23 ES ES445450A patent/ES445450A1/en not_active Expired
- 1976-03-01 FR FR7605762A patent/FR2318159A1/en active Granted
- 1976-03-03 BE BE164793A patent/BE839120A/en not_active IP Right Cessation
- 1976-03-05 CH CH280676A patent/CH629192A5/en not_active IP Right Cessation
- 1976-03-08 NO NO760790A patent/NO144884C/en unknown
- 1976-03-08 JP JP51024280A patent/JPS51115473A/en active Pending
- 1976-03-08 DK DK99376*#A patent/DK99376A/en not_active Application Discontinuation
- 1976-03-08 CS CS761495A patent/CS203116B2/en unknown
- 1976-03-08 IT IT48460/76A patent/IT1057941B/en active
- 1976-03-08 DE DE19762609573 patent/DE2609573A1/en not_active Withdrawn
- 1976-03-08 LU LU74503A patent/LU74503A1/xx unknown
- 1976-03-09 FI FI760601A patent/FI62292C/en not_active IP Right Cessation
- 1976-03-09 AU AU11806/76A patent/AU503733B2/en not_active Expired
- 1976-03-09 PT PT64879A patent/PT64879B/en unknown
- 1976-03-09 HU HU76JA00000750A patent/HU172026B/en unknown
- 1976-03-09 ZA ZA761427A patent/ZA761427B/en unknown
- 1976-03-09 AT AT171776A patent/AT353262B/en not_active IP Right Cessation
- 1976-03-09 YU YU00608/76A patent/YU60876A/en unknown
- 1976-03-09 IE IE482/76A patent/IE42652B1/en unknown
- 1976-03-09 NL NL7602444A patent/NL7602444A/en not_active Application Discontinuation
- 1976-03-10 SU SU762329945A patent/SU677656A3/en active
- 1976-03-10 BG BG032575A patent/BG24806A3/en unknown
- 1976-03-10 IL IL49190A patent/IL49190A/en unknown
- 1976-03-10 PL PL1976187827A patent/PL99926B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT64879A (en) | 1976-04-01 |
| BG24806A3 (en) | 1978-05-12 |
| DE2609573A1 (en) | 1976-09-30 |
| ES445450A1 (en) | 1977-10-16 |
| IT1057941B (en) | 1982-03-30 |
| YU60876A (en) | 1983-01-21 |
| NO144884C (en) | 1981-12-02 |
| SU677656A3 (en) | 1979-07-30 |
| CH629192A5 (en) | 1982-04-15 |
| AU1180676A (en) | 1977-09-15 |
| AU503733B2 (en) | 1979-09-20 |
| FI62292C (en) | 1982-12-10 |
| NL7602444A (en) | 1976-09-14 |
| CS203116B2 (en) | 1981-02-27 |
| SE7601959L (en) | 1976-09-13 |
| GB1535566A (en) | 1978-12-13 |
| HU172026B (en) | 1978-05-28 |
| PL99926B1 (en) | 1978-08-31 |
| ATA171776A (en) | 1979-04-15 |
| LU74503A1 (en) | 1976-09-01 |
| JPS51115473A (en) | 1976-10-12 |
| FI62292B (en) | 1982-08-31 |
| PT64879B (en) | 1978-02-06 |
| DK99376A (en) | 1976-09-11 |
| NO144884B (en) | 1981-08-24 |
| CA1066709A (en) | 1979-11-20 |
| FI760601A (en) | 1976-09-11 |
| FR2318159A1 (en) | 1977-02-11 |
| IL49190A (en) | 1980-07-31 |
| AT353262B (en) | 1979-11-12 |
| ZA761427B (en) | 1977-10-26 |
| IL49190A0 (en) | 1976-05-31 |
| IE42652B1 (en) | 1980-09-24 |
| FR2318159B1 (en) | 1979-07-27 |
| BE839120A (en) | 1976-09-03 |
| NO760790L (en) | 1976-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU40297B (en) | Process for transforming esters of cis-or trans-2,2-dimethyl-3r-(2,2-dihalovinyl)-cyclopropane-1r-carboxylic acid | |
| ES8405387A1 (en) | Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure. | |
| FR2289484A1 (en) | ESTERS OF CYCLOPROPANECARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR USE IN PARTICULAR AS INSECTICIDES | |
| IE42500L (en) | N-acyl-l-methionines. | |
| IE42652L (en) | Optically pure imidazole carboxylates | |
| EP0212688A3 (en) | Substituted and crosslinked glucans, process for preparing them and use thereof | |
| ES478413A1 (en) | Process for removing heavy-metal ions from aqueous solutions | |
| CA2347758A1 (en) | Method for racemate splitting of 2-hydroxypropionic acids | |
| GB1448316A (en) | Racemization of optically active 2,2-dimethyl-3,1,-alkenyl- cyclopropane-1-carboxylic acids | |
| AU626986B2 (en) | A process for the improved production of (meth)acrylic acid esters of polyhydric alcohols (i) | |
| AU554133B2 (en) | Method of treating acne using 13-cis-retinoic acid | |
| ZA82502B (en) | Process for the preparation of optically active 2-chloropropionic acid esters | |
| EP0016610A3 (en) | Method for preserving an e-type prostaglandin and stabilized pge-type in triethyl citrate solution | |
| AU5325379A (en) | Process for decomposing formic acid esters | |
| ATA385984A (en) | Process for the preparation of novel optically active tert-butyl esters of tartaric acid and some O,O-diacyl derivatives | |
| YU60778A (en) | Process for the enzymatic hydrolysis of racemic hydantoin into optically active amino-acids | |
| DE3571133D1 (en) | A process for preparing lysergol derivatives | |
| ES8506689A1 (en) | Cumalincarboxylic-acid esters, process for their preparation and agricultural fungicides. | |
| ES479523A1 (en) | Process for preparing vulcanizable acrylic elastomers | |
| SU808331A1 (en) | Method of making boards from grapevine branches | |
| AU561146B2 (en) | Fermentation process to produce lower alkyl esters of alpha- l-aspartyl-lphenyl-alanine | |
| ES475527A1 (en) | Process for the preparation of DL-phenyl-glycine amide. | |
| JPS5764677A (en) | Preparation of n-acylcarnosine | |
| JPS5332190A (en) | Immobilization of glucoseisomerase | |
| UA7439A1 (en) | Process for preparation of preservative agent for storage of tuberous roots |