IE41708L - 2,6-dioxo-tetra- and -hexa-hydropyridine derivatives - Google Patents

2,6-dioxo-tetra- and -hexa-hydropyridine derivatives

Info

Publication number
IE41708L
IE41708L IE751347A IE134775A IE41708L IE 41708 L IE41708 L IE 41708L IE 751347 A IE751347 A IE 751347A IE 134775 A IE134775 A IE 134775A IE 41708 L IE41708 L IE 41708L
Authority
IE
Ireland
Prior art keywords
methyl
alkyl
dioxo
piperidyl
piperidine
Prior art date
Application number
IE751347A
Other versions
IE41708B1 (en
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Publication of IE41708L publication Critical patent/IE41708L/en
Publication of IE41708B1 publication Critical patent/IE41708B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1457619 2,6 - Dioxo - tetra- and hexahydropyridines ASPRO-NICHOLAS Ltd 23 June 1975 [22 June 1974] 27819/74 Heading C2C The invention comprises the title compounds, and their acid addition salts and quaternary ammonium derivatives, which contain (a) possibly a 1-alkyl substituent, (b) 3- (optionally substituted) Ph and 3-heterocyclyl- C 1-5 -alkyl substituents, as well as (c) 4- and/or 5-attached C 1-4 alkyl or C 3-8 (inclusive of the attached ring carbon atom or atoms) alkylene substituent, the "heterocyclyl" being derived from a non-aromatic N-containing 5-7 membered ring. The "alkyl" and "alkylene" radicals include unsaturated analogues. In an example, 1 - methyl - 2 - (2 - hydroxyethyl)pyridinium methosulphate is reduced to 1-methyl-2-(2- hydroxyethyl)piperidine which with SOCl 2 affords 1 - methyl - 2 - (2 - chloroethyl)piperidine, the latter condensed with m-methoxybenzyl cyanide to give 2 - (m - methoxyphenyl) - 4- (N - methyl - 2 - piperidyl)butyronitrile and then with 4 - (1 - ethoxy - 3 - methylbut - 2 - enylidene)morpholinium fluorosulphonate to give 2 - (1,1 - dimethyl - 2 - ethoxyethyl) - 2 - (mmethoxyphenyl) - 4 - (N - methyl - 2 - piperidyl)- butyronitrile, the latter being cyclized to 4,4-dimethyl - 2,6 - dioxo - 3 - m - methoxyphenyl- 3 - [2 - (N - methyl - 2 - piperidyl)ethyl]piperidine. Therapeutic compositions having C.N.S. activity comprise the title compounds, substituted as described above, and may be administered orally, parenterally or rectally. [GB1457619A]
IE1347/75A 1974-06-22 1975-06-16 2,6-dioxo-tetra and hexahydro-pyridine derivatives IE41708B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2781974A GB1457619A (en) 1974-06-22 1974-06-22 2,6-dioxo-tetra and hexahydropyridine derivatives apparatuses for transferring threads from spinning and finishing parts of machines for continuous production of artificial threads to take-up and winding arrangements thereof

Publications (2)

Publication Number Publication Date
IE41708L true IE41708L (en) 1975-12-22
IE41708B1 IE41708B1 (en) 1980-03-12

Family

ID=10265816

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1347/75A IE41708B1 (en) 1974-06-22 1975-06-16 2,6-dioxo-tetra and hexahydro-pyridine derivatives

Country Status (10)

Country Link
JP (1) JPS51136675A (en)
AU (1) AU8222775A (en)
BE (1) BE830462A (en)
DE (1) DE2527581A1 (en)
DK (1) DK277275A (en)
FR (1) FR2275201A1 (en)
GB (1) GB1457619A (en)
IE (1) IE41708B1 (en)
NL (1) NL7507421A (en)
ZA (1) ZA753902B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011234A1 (en) * 1993-10-22 1995-04-27 Australian Nuclear Science & Technology Organisation Radiolabelled ligands for muscarinic receptors

Also Published As

Publication number Publication date
ZA753902B (en) 1977-01-26
DE2527581A1 (en) 1976-01-08
IE41708B1 (en) 1980-03-12
FR2275201A1 (en) 1976-01-16
GB1457619A (en) 1976-12-08
BE830462A (en) 1975-12-22
JPS51136675A (en) 1976-11-26
NL7507421A (en) 1975-12-24
DK277275A (en) 1975-12-23
AU8222775A (en) 1976-12-23

Similar Documents

Publication Publication Date Title
EP0176927A3 (en) Diazepine-containing pharmaceutical compositions having a platelet activating factor (paf)-antagonist action
KR830001926A (en) Method for preparing novel quinazolin derivatives and addition salts thereof
ZA925682B (en) New benzimidazolone derivatives
SE7714184L (en) PIPERAZINE DERIVATIVES
DK0593478T3 (en) Leukotriene B4 antagonists
DK12087A (en) DECAHYDROQUINOLINE DERIVATIVES, THEIR PREPARATION AND USE, AND PREPARATIONS WITH CONTENTS
DK26289A (en) USE OF 1,4-DISUBSTITUTED PIPERIDINYL FOR THE PREPARATION OF A PHARMACEUTICAL PREPARATION FOR TREATING INSOMNIA
ES8502099A1 (en) Derivatives of dihydrodibenzocycloheptylidene-ethylamine.
ES469900A1 (en) A PROCEDURE FOR THE PREPARATION OF M-PHENO-XIBENZAMIDE DERIVATIVES
IE41708L (en) 2,6-dioxo-tetra- and -hexa-hydropyridine derivatives
GR78961B (en)
EP0347902A3 (en) Pyrrolecarboxylic acid derivatives
KR960702456A (en) NP-Halobenzoylmethyl Derivatives of 4- (P-Fluorophenyl) -3-[(3,4- (methylenedioxy) phenoxy) methyl] piperidine ) -3-[[3,4- (METHYLENEDIOXY) PHENOXY] METHYL] PIPERIDINE)
GB1498884A (en) Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives
DE3482418D1 (en) HYDROXYETHYLAZOLYL OXIME DERIVATIVES.
DE3363740D1 (en) 3-pyridyl-5-alkoxy-(or phenoxy- or aralkyloxy-)pyrazole derivatives, process for their preparation, and their therapeutical use
NO960647D0 (en) Vasoconstrictively substituted dihydropyranopyridines
EP0653207A4 (en) COMPOSITION FOR INHIBITING AN AIDS VIRUS INFECTION.
GB1164496A (en) 0-Oxaphenanthridine Derivatives and Method for the Preparation
KR960704838A (en) Difluoro statone antiviral analogs
ATE25584T1 (en) USE OF GAMMA PIPERIDINO BUTYROPHENONES IN THE MANUFACTURE OF PHARMACEUTICALS FOR THE TREATMENT OF DIARRHOEA.
CA2211889A1 (en) Vasoconstrictive substituted 2,3-dihydro-1,4-dioxinopyridines
JPS5283566A (en) 3-hydroxypiperidine derivatives
FR2327789A1 (en) 2- (4- (TETRAHYDRO-2-FUROYL) -HEXAHYDRO -1,4-DIAZEPINO) -4-AMINO -6,7-DIMETHOXY-QUINAZOLINE AND ITS ADDITIONAL SALTS OF ACIDS USEFUL IN PARTICULAR AS HYPOTENSORING AGENTS
JPS51115918A (en) Germicides for the porposes withowt medical treatment and method for p reparing them