IE41273L - 7-aminoalkoxy benzopyran derivatives - Google Patents
7-aminoalkoxy benzopyran derivativesInfo
- Publication number
- IE41273L IE41273L IE751647A IE164775A IE41273L IE 41273 L IE41273 L IE 41273L IE 751647 A IE751647 A IE 751647A IE 164775 A IE164775 A IE 164775A IE 41273 L IE41273 L IE 41273L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen atom
- compound
- alkyl
- lower alkyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compounds of the formula II are prepared <IMAGE> in which X is alkylene having 2 to 4 carbon atoms, Y is an oxygen or sulphur atom or a CH2 group; R1 is a hydrogen atom or lower alkyl; R2 is a hydrogen atom, lower alkyl, phenyl, tolyl or benzyl, or R2 is bonded to R1 with the formation of a 5-, 6- or 7-membered ring; R3 is aryl, aralkyl or a pyridyl, furyl, thienyl or pyrrolidyl radical, R4 is a hydrogen atom or C1-4-alkyl and R5 is a hydrogen atom or C1-4-alkyl, by reaction of an appropriate 7-OH compound with a compound Q1-X-NR1R2 or a compound Q1XQ2, in which Q1 and Q2 are groups which are easily removable by a nucleophile, and subsequent reaction with an amine HNR1R2. The compounds prepared according to the invention act on the central nervous system. Depending on the dose administered, they act as appetite suppressants or affect the mood of the person.
[GB1486001A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB33549/74A GB1486001A (en) | 1974-07-30 | 1974-07-30 | 7-aminoalkoxy substituted benzopyrans benzo thiopyrans and naphthalenes |
Publications (2)
Publication Number | Publication Date |
---|---|
IE41273L true IE41273L (en) | 1976-01-30 |
IE41273B1 IE41273B1 (en) | 1979-11-21 |
Family
ID=10354390
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE1647/75A IE41273B1 (en) | 1974-07-30 | 1975-07-23 | 7-aminoalkoxy substituted benzopyrans, benzo thiopyrans and naphthalenes |
Country Status (17)
Country | Link |
---|---|
US (1) | USRE30739E (en) |
JP (1) | JPS51125055A (en) |
AR (1) | AR210500A1 (en) |
AT (1) | AT345283B (en) |
AU (1) | AU500006B2 (en) |
BE (1) | BE831939A (en) |
CA (1) | CA1077478A (en) |
CH (3) | CH622789A5 (en) |
DE (1) | DE2533885A1 (en) |
DK (1) | DK344175A (en) |
ES (1) | ES439856A1 (en) |
FR (2) | FR2280368A1 (en) |
GB (1) | GB1486001A (en) |
IE (1) | IE41273B1 (en) |
IL (1) | IL47826A (en) |
SE (1) | SE420490B (en) |
ZA (1) | ZA754821B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2408600A1 (en) * | 1977-10-11 | 1979-06-08 | Beecham Group Ltd | 7-Amino-alkoxy-3-phenyl-2,2-di:methyl-chroman derivs. - are optically active and have antidepressant and appetite suppressant activity |
JPS5832847A (en) * | 1981-08-20 | 1983-02-25 | Mitsubishi Chem Ind Ltd | (3-aminopropoxy)bibenzyl compound |
FR2639227A1 (en) * | 1988-11-23 | 1990-05-25 | Sanofi Sa | USE OF CHROMANE DERIVATIVES FOR THE TREATMENT OF DEPRESSIVE STATES |
US5166367A (en) * | 1991-06-21 | 1992-11-24 | American Home Products Corporation | Antipsychotic benzodioxan derivatives |
GB2271566A (en) * | 1992-10-14 | 1994-04-20 | Merck & Co Inc | HIV integrase inhibitors |
US6017768A (en) * | 1994-05-06 | 2000-01-25 | Pharmacopeia, Inc. | Combinatorial dihydrobenzopyran library |
CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
EP2725026B1 (en) * | 2012-10-29 | 2017-09-06 | Symrise AG | Heterocyclic neoflavonoids with taste masking properties |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3476767A (en) * | 1965-10-11 | 1969-11-04 | Ciba Geigy Corp | 1,2-diaryl - 6 - tertiary amino lower-alkoxy-3,4-dihydro naphthalenes |
GB1357633A (en) * | 1971-03-02 | 1974-06-26 | Beecham Group Ltd | Chromanone basic ether derivatives |
-
1974
- 1974-07-30 GB GB33549/74A patent/GB1486001A/en not_active Expired
-
1975
- 1975-07-23 SE SE7508414A patent/SE420490B/en unknown
- 1975-07-23 IE IE1647/75A patent/IE41273B1/en unknown
- 1975-07-28 ZA ZA00754821A patent/ZA754821B/en unknown
- 1975-07-28 IL IL47826A patent/IL47826A/en unknown
- 1975-07-28 FR FR7523453A patent/FR2280368A1/en active Granted
- 1975-07-28 AT AT582775A patent/AT345283B/en not_active IP Right Cessation
- 1975-07-29 DE DE19752533885 patent/DE2533885A1/en not_active Withdrawn
- 1975-07-29 CA CA232,421A patent/CA1077478A/en not_active Expired
- 1975-07-29 DK DK344175A patent/DK344175A/en not_active Application Discontinuation
- 1975-07-30 BE BE158788A patent/BE831939A/en unknown
- 1975-07-30 JP JP50092980A patent/JPS51125055A/en active Pending
- 1975-07-30 ES ES439856A patent/ES439856A1/en not_active Expired
- 1975-07-30 AU AU83536/75A patent/AU500006B2/en not_active Ceased
- 1975-07-30 CH CH997275A patent/CH622789A5/en not_active IP Right Cessation
-
1976
- 1976-01-16 FR FR7601065A patent/FR2313025A1/en active Granted
- 1976-06-28 AR AR263765A patent/AR210500A1/en active
-
1979
- 1979-05-14 US US06/038,737 patent/USRE30739E/en not_active Expired - Lifetime
- 1979-05-30 CH CH503879A patent/CH624111A5/en not_active IP Right Cessation
- 1979-05-30 CH CH503779A patent/CH624110A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS51125055A (en) | 1976-11-01 |
CH622789A5 (en) | 1981-04-30 |
GB1486001A (en) | 1977-09-14 |
FR2313025A1 (en) | 1976-12-31 |
CA1077478A (en) | 1980-05-13 |
ES439856A1 (en) | 1977-06-16 |
SE7508414L (en) | 1976-02-02 |
AR210500A1 (en) | 1977-08-15 |
IE41273B1 (en) | 1979-11-21 |
DE2533885A1 (en) | 1976-02-19 |
FR2280368B1 (en) | 1979-08-10 |
FR2280368A1 (en) | 1976-02-27 |
AU8353675A (en) | 1977-02-03 |
AU500006B2 (en) | 1979-05-10 |
ZA754821B (en) | 1976-07-28 |
BE831939A (en) | 1976-01-30 |
ATA582775A (en) | 1978-01-15 |
SE420490B (en) | 1981-10-12 |
CH624111A5 (en) | 1981-07-15 |
CH624110A5 (en) | 1981-07-15 |
IL47826A (en) | 1979-05-31 |
FR2313025B1 (en) | 1979-10-05 |
USRE30739E (en) | 1981-09-08 |
DK344175A (en) | 1976-01-31 |
IL47826A0 (en) | 1975-10-15 |
AT345283B (en) | 1978-09-11 |
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