IE40370B1 - Process for preparing injectable compositions - Google Patents
Process for preparing injectable compositionsInfo
- Publication number
- IE40370B1 IE40370B1 IE158/75A IE15875A IE40370B1 IE 40370 B1 IE40370 B1 IE 40370B1 IE 158/75 A IE158/75 A IE 158/75A IE 15875 A IE15875 A IE 15875A IE 40370 B1 IE40370 B1 IE 40370B1
- Authority
- IE
- Ireland
- Prior art keywords
- allergen
- dialdehyde
- extract
- tyrosine
- aqueous solution
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
1492973 Modified allergens BEECHAM GROUP Ltd 5 Feb 1975 [16 Feb 1974] 7156/74 Addition to 1377074 Heading A5B Finely divided micro-particles of tyrosine having a water soluble dialdehyde - treated allergen dispersed therein are prepared by mixing an aqueous solution of a water - soluble dialdehyde e.g. glutaraldehyde modified allergenic extract of an allergenic material with a solution of tyrosine in a strong aqueous acid e.g. hydrochloric acid; and simultaneously or subsequently neutralising (i.e. adjusting the pH to from 4 to 7.5) such mixture of solutions thereby precipitating the required product. Sodium hydroxide may be employed to neutralise the reaction mixture. The aqueous solution of modified allergen may be obtained directly by reacting an aqueous solution of an extract of allergenic material with a dialdehyde under neutral conditions. The allergen may be an extract of one or more pollens e.g. grass or ragweed pollen; house dust, the house dust mite Dermatophagoides pteronyssinus, moulds, animal hair, dander or fur. The precipitate of tyrosine containing the dialdehyde treated allergen may be removed from the solution by centrifugation or filtration and washed before being resuspended in a physiologically acceptable carrier such as phenol-saline or sterile water, to produce an injectable composition for use in desensitisation therapy.
[GB1492973A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7156/74A GB1492973A (en) | 1974-02-16 | 1974-02-16 | Process for preparing injectable compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40370L IE40370L (en) | 1975-08-16 |
| IE40370B1 true IE40370B1 (en) | 1979-05-09 |
Family
ID=9827690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE158/75A IE40370B1 (en) | 1974-02-16 | 1975-01-27 | Process for preparing injectable compositions |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5822444B2 (en) |
| BE (1) | BE825579R (en) |
| DE (1) | DE2505814C2 (en) |
| FR (1) | FR2261013B2 (en) |
| GB (1) | GB1492973A (en) |
| IE (1) | IE40370B1 (en) |
| KE (1) | KE3113A (en) |
| NL (1) | NL186295C (en) |
| ZA (1) | ZA75634B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234569A (en) * | 1978-10-04 | 1980-11-18 | The Johns Hopkins University | Production of aldehyde-treated allergen-containing substances |
| US5057317A (en) * | 1987-03-24 | 1991-10-15 | Chugai Seiyaku Kabushiki Kaisha | Slow-release pharmaceutical agent |
| GB9706957D0 (en) * | 1997-04-05 | 1997-05-21 | Smithkline Beecham Plc | Formulation |
| PT1024829E (en) | 1997-10-30 | 2009-03-18 | Leti Sl Lab | Tolerogenic fragments of natural allergens |
| GB9820525D0 (en) | 1998-09-21 | 1998-11-11 | Allergy Therapeutics Ltd | Formulation |
| GB0000891D0 (en) | 2000-01-14 | 2000-03-08 | Allergy Therapeutics Ltd | Formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3541201A (en) * | 1968-12-18 | 1970-11-17 | Ethan Alan Brown | Novel sodium chloride encapsulated injectionable substances |
| BE754523A (en) * | 1969-08-06 | 1971-02-08 | Beecham Group Ltd | VACCINES |
| GB1377074A (en) * | 1971-07-13 | 1974-12-11 | Beecham Group Ltd | Process for preparing injectable compositions |
-
1974
- 1974-02-16 GB GB7156/74A patent/GB1492973A/en not_active Expired
-
1975
- 1975-01-27 IE IE158/75A patent/IE40370B1/en unknown
- 1975-01-30 ZA ZA00750634A patent/ZA75634B/en unknown
- 1975-02-07 FR FR7503870A patent/FR2261013B2/fr not_active Expired
- 1975-02-11 NL NLAANVRAGE7501582,A patent/NL186295C/en not_active IP Right Cessation
- 1975-02-12 DE DE2505814A patent/DE2505814C2/en not_active Expired
- 1975-02-14 JP JP50018110A patent/JPS5822444B2/en not_active Expired
- 1975-02-14 BE BE153404A patent/BE825579R/en active
-
1981
- 1981-01-21 KE KE3113A patent/KE3113A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA75634B (en) | 1976-01-28 |
| GB1492973A (en) | 1977-11-23 |
| BE825579R (en) | 1975-08-14 |
| DE2505814A1 (en) | 1975-09-18 |
| NL186295B (en) | 1990-06-01 |
| FR2261013B2 (en) | 1978-07-21 |
| JPS5822444B2 (en) | 1983-05-09 |
| NL7501582A (en) | 1975-08-19 |
| AU7794375A (en) | 1976-08-05 |
| KE3113A (en) | 1981-02-20 |
| IE40370L (en) | 1975-08-16 |
| DE2505814C2 (en) | 1984-11-15 |
| FR2261013A2 (en) | 1975-09-12 |
| JPS50116626A (en) | 1975-09-12 |
| NL186295C (en) | 1990-11-01 |
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