IE38846L - Carbalkoxythioureidobenzene derivatives and intermediate¹nitroaniline derivatives - Google Patents

Carbalkoxythioureidobenzene derivatives and intermediate¹nitroaniline derivatives

Info

Publication number
IE38846L
IE38846L IE740269A IE26974A IE38846L IE 38846 L IE38846 L IE 38846L IE 740269 A IE740269 A IE 740269A IE 26974 A IE26974 A IE 26974A IE 38846 L IE38846 L IE 38846L
Authority
IE
Ireland
Prior art keywords
carbon atoms
alkyl
nhc
aryl
aralkyl
Prior art date
Application number
IE740269A
Other versions
IE38846B1 (en
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/434,656 external-priority patent/US4072696A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of IE38846L publication Critical patent/IE38846L/en
Publication of IE38846B1 publication Critical patent/IE38846B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1460641 Aikoxycarbonylthioureido-benzenes SYNTEX (USA) Inc 11 Feb 1974 [12 Feb 1973 18 Jan 1974] 06058/74 Heading C2C The invention comprises novel compounds (I) where R is an alkyl group having 1 to 4 carbon atoms; R<SP>1</SP> is -SR<SP>2</SP>, -SOR<SP>2</SP>, -SO 2 R<SP>2</SP>, -OR<SP>2</SP>, -SCN, -SC(O)NR<SP>3</SP>R<SP>4</SP>, or -M<SP>1</SP>(CH 2 ) n MR<SP>7</SP> where n is 1-4; R<SP>2</SP> is optionally substituted alkyl having 1 to 6 carbon atoms, cycloalkyl having 3 to 7 carbon atoms, or optionally substituted alkenyl or alkynyl having 3 to 6 carbon atoms, aralkyl or aryl or substituted aralkyl or aryl, provided that when R<SP>1</SP> is -SO 2 R<SP>2</SP>, R<SP>2</SP> is not aralkyl or phenyl; R<SP>3</SP> and R<SP>4</SP> are independently hydrogen or alkyl having 1 to 6 carbon atoms; Y is amino, nitro, acylamino where the acyl portion has 1 to 6 carbon atoms, where m is 1-6, or-NHC(S)NHCOOR; M and M<SP>1</SP> are independently O, S or and R<SP>7</SP> is alkyl having 1 to 4 carbon atoms or aryl; and the pharmaceutically acceptable salts thereof; with the proviso that when R<SP>1</SP> is alkoxy, Y is -NHC(S)NHCOOR or -NHC(O)(CH 2 ) m COOH. They are made by utilizing the following reaction scheme (many of the intermediates and starting materials shown in the scheme are prepared and isolated; Ac is acyl and Z is R<SP>2</SP>SO or R<SP>2</SP>SO 2 ). Pharmaceutical preparations showing especially anthelmintic and antifungal actions contain (I) as active ingredient. Administration is, e.g. orally. [GB1460641A]
IE269/74A 1973-02-12 1974-02-12 Carbalkoxythiouredobenzene derivatives having anthelmintic properties IE38846B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33185273A 1973-02-12 1973-02-12
US05/434,656 US4072696A (en) 1973-02-12 1974-01-18 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity

Publications (2)

Publication Number Publication Date
IE38846L true IE38846L (en) 1974-08-12
IE38846B1 IE38846B1 (en) 1978-06-07

Family

ID=26987956

Family Applications (1)

Application Number Title Priority Date Filing Date
IE269/74A IE38846B1 (en) 1973-02-12 1974-02-12 Carbalkoxythiouredobenzene derivatives having anthelmintic properties

Country Status (11)

Country Link
JP (1) JPS5046641A (en)
BR (1) BR7401013D0 (en)
CA (1) CA1028337A (en)
DE (1) DE2462258C2 (en)
ES (1) ES423164A1 (en)
FR (2) FR2217015B1 (en)
GB (2) GB1460641A (en)
IE (1) IE38846B1 (en)
IN (1) IN139876B (en)
IT (1) IT1051603B (en)
NL (1) NL180212C (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2541742C2 (en) * 1975-09-19 1983-04-28 Hoechst Ag, 6230 Frankfurt o-Nitro-phenyl-thionocarbamoyl-carbaminate and process for their preparation
US4060636A (en) 1976-06-10 1977-11-29 Rohm And Haas Company Acetyl- and carbalkoxythioureidobenzophenones as anthelmintic agents
HU195950B (en) * 1984-02-29 1988-08-29 Richter Gedeon Vegyeszet Process for producing nitramino-diaryl-sulfoxide derivatives and pharmaceutics comprising such compounds
HU195949B (en) * 1984-02-29 1988-08-29 Richter Gedeon Vegyeszet Process for producing new nitro-diaryl-sulfoxide derivatives and pharmaceutics comprising such compounds
HU195951B (en) * 1984-02-29 1988-08-29 Richter Gedeon Vegyeszet Process for producing amino-diaryl-sulfoxide derivatives and pharmaceutics comprising such compounds
DE19829357A1 (en) 1998-07-01 2000-01-05 Bayer Ag Process for the preparation of 2-nitro-5- (phenylthio) anilines

Also Published As

Publication number Publication date
GB1460642A (en) 1977-01-06
DE2462258C2 (en) 1982-01-28
NL180212B (en) 1986-08-18
NL7401797A (en) 1974-08-14
DE2406584A1 (en) 1974-09-12
DE2406584B2 (en) 1977-03-31
FR2283126A1 (en) 1976-03-26
ES423164A1 (en) 1976-09-16
BR7401013D0 (en) 1974-11-05
FR2283126B1 (en) 1980-06-27
NL180212C (en) 1987-01-16
AU6543374A (en) 1975-08-14
CA1028337A (en) 1978-03-21
FR2217015B1 (en) 1978-07-21
GB1460641A (en) 1977-01-06
IT1051603B (en) 1981-05-20
DE2462258A1 (en) 1976-07-08
JPS5046641A (en) 1975-04-25
FR2217015A1 (en) 1974-09-06
IE38846B1 (en) 1978-06-07
IN139876B (en) 1976-08-14

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