IE38646L - Morpholine and oxazine derivatives. - Google Patents

Morpholine and oxazine derivatives.

Info

Publication number
IE38646L
IE38646L IE227273A IE227273A IE38646L IE 38646 L IE38646 L IE 38646L IE 227273 A IE227273 A IE 227273A IE 227273 A IE227273 A IE 227273A IE 38646 L IE38646 L IE 38646L
Authority
IE
Ireland
Prior art keywords
compound
reacting
alkyl
followed
trifluoromethylphenyl
Prior art date
Application number
IE227273A
Other versions
IE38646B1 (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE38646L publication Critical patent/IE38646L/en
Publication of IE38646B1 publication Critical patent/IE38646B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1394001 2 - (Morpholino or homomorpholino) - 1 - (3 - trifluoromethylphenyl) propanes PFIZER Ltd 19 Dec 1973 [22 Dec 1972] 59360/72 Heading C2C Novel compounds of the Formula I in which R is hydrogen or halogen; R<SP>1</SP> is alkyl; R<SP>3</SP> and R<SP>4</SP> each are hydrogen, alkyl or phenyl; R<SP>5</SP> is hydrogen or alkyl and n is 1 or 2 wherein alkyl groups are C 1-4 groups and non-toxic acid addition salts thereof may be prepared by (1) reacting a compound II with an appropriately substituted morpholine or homomorpholine followed by reduction of the intermediate ethylene derivative; (2) reacting a compound VI wherein X is halogen or an alkyl or arylsulphonyloxy group with the morpholine or homomorpholine; (3) reacting a compound VIII with a 2,2<SP>1</SP>-dichlorodiethyl ether or a substituted derivative thereof ClCHR<SP>5</SP>CHR<SP>4</SP>OCHR<SP>3</SP>CH 2 Cl; (4) reacting a compound of the Formula XVIII with a chloracetylchloride ClCHR 3 COCl, to yield a compound XIX followed by dehydrohalogenation to cyclize to the compound XX followed by reduction of the keto group; (5) reacting a compound of the Formula XVIII with an epoxide X followed by dehydration of the product of the Formula XVI or other equivalent processes. 1 - (3 - Trifluoromethylphenyl) - 2 - p - toluene sulphonyloxypropane may be prepared by esterification of 1 - (3 - trifluoromethylphenyl)- propan-2-ol with p-toluenesulphonylchloride. Pharmaceutical compositions of the compounds I alone or with the usual excipients may be administered orally or parenterally to reduce the appetite. [GB1394001A]
IE227273A 1972-12-22 1973-12-17 2-(morpholino or perhydro-1,4-oxazepin4-yl)-1-(3-trifluoromethylphenyl)-alkanes IE38646B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5936072A GB1394001A (en) 1972-12-22 1972-12-22 2-morpholino or homomorpholino 1-3-trifluoromethylphenyl propanes

Publications (2)

Publication Number Publication Date
IE38646L true IE38646L (en) 1974-06-22
IE38646B1 IE38646B1 (en) 1978-04-26

Family

ID=10483613

Family Applications (1)

Application Number Title Priority Date Filing Date
IE227273A IE38646B1 (en) 1972-12-22 1973-12-17 2-(morpholino or perhydro-1,4-oxazepin4-yl)-1-(3-trifluoromethylphenyl)-alkanes

Country Status (6)

Country Link
JP (1) JPS4994685A (en)
BE (1) BE809039A (en)
DE (1) DE2361824A1 (en)
FR (1) FR2211251B1 (en)
GB (1) GB1394001A (en)
IE (1) IE38646B1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1258454A (en) * 1982-08-10 1989-08-15 Leo Alig Phenethanolamines
ZA835687B (en) * 1982-08-10 1984-03-28 Hoffmann La Roche Novel phenethanolamines
DE3476386D1 (en) * 1983-11-02 1989-03-02 Beecham Group Plc MORPHOLINE DERIVATIVES

Also Published As

Publication number Publication date
DE2361824A1 (en) 1974-08-01
FR2211251A1 (en) 1974-07-19
FR2211251B1 (en) 1978-01-06
IE38646B1 (en) 1978-04-26
JPS4994685A (en) 1974-09-09
GB1394001A (en) 1975-05-14
BE809039A (en) 1974-06-21

Similar Documents

Publication Publication Date Title
IE39835B1 (en) Oxepin derivatives
GB1451999A (en) Quinone derivatives
US4093813A (en) Inter-oxa-13,14-dihydro-9-deoxy-PGF compounds
IE38646L (en) Morpholine and oxazine derivatives.
GB1528074A (en) 11-deoxyprostaglandins
GB652207A (en) Improvements in or relating to the preparation of thyroxine and its derivatives
GB1317034A (en) 1-2-hydroxy-3-phenoxy- or -phenylthiopropyl-piperazine derivatives
SE7601206L (en) ACETYLENE DERIVATIVES
SE7706509L (en) SPIRO ((7-ACYLTIO-4-OSTREN OR-ANDROSTEN-3-ON) -17 BETA, 2 &#39;- (4&#39;-CARBONIC ACID-1&#39;-OXACYCLOPENTAN-5&#39;-ON)) AND ESTRES THEREOF
GB1397169A (en) Phenylpiperazine derivatives process for their preparation and applications thereof
ES439291A1 (en) Novel derivative of N-(3,4,5-trimethoxy cinnamoyl) piperazine, its acid addition salts, its process of preparation and its therapeutic application
IE36485B1 (en) Benzothiophene derivatives and process for preparing same
SE415095B (en) PROCEDURE FOR PREPARING 8,12-DIISOPROSTANIC ACID DERIVATIVES
ES427614A1 (en) 9-Hydroxy prosta-5-cis, 11,13-trans-trienoic acids and derivatives thereof
GB1436357A (en) Tri-iodo benzene derivatives and their use as x-ray contrast
GB1135907A (en) Process for the production of coumarin derivatives
US3974190A (en) 16-Fluoro prostaglandin A1 analogs
ES480294A2 (en) Improvements introduced in the object of the main patent by procedure for the production of hydroxylamins or rented. (Machine-translation by Google Translate, not legally binding)
SE7606497L (en) SUBSTITUTED 4-PHENYLIMIDAZOLINES, THEIR ACID ADDITINOS SALTS AND PROCEDURES FOR THE PREPARATION
GB1512537A (en) 2-(2&#39;-aryl-6&#39;-chromonyl) propionic acids and analgesic and anti-inflammatory derivatives thereof
ES412068A1 (en) Xylidides
GB1525282A (en) 16-chloroprostaglandin analogues
IE38611L (en) Sydnone derivatives.
GB1351184A (en) Dibenzoxazepine and dibenzothiazepine derivatives
US4321370A (en) 2,5-Inter-o-phenylene-3,4-dinor-6,9α-epoxy-6β-PGF1 compounds