IE37326B1 - Antihypertensive compositions - Google Patents
Antihypertensive compositionsInfo
- Publication number
- IE37326B1 IE37326B1 IE303/73A IE30373A IE37326B1 IE 37326 B1 IE37326 B1 IE 37326B1 IE 303/73 A IE303/73 A IE 303/73A IE 30373 A IE30373 A IE 30373A IE 37326 B1 IE37326 B1 IE 37326B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- radical
- halogen
- phenyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000003276 anti-hypertensive effect Effects 0.000 title 1
- -1 hexahydroazepino Chemical group 0.000 abstract 5
- RPTUSVTUFVMDQK-UHFFFAOYSA-N Hidralazin Chemical compound C1=CC=C2C(NN)=NN=CC2=C1 RPTUSVTUFVMDQK-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 229960002474 hydralazine Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 abstract 1
- 239000000674 adrenergic antagonist Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 125000004069 aziridinyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00232294A US3833727A (en) | 1972-03-06 | 1972-03-06 | Hydralazine and beta-adrenergic blocking agent compositions for treating hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37326L IE37326L (en) | 1973-09-06 |
| IE37326B1 true IE37326B1 (en) | 1977-06-22 |
Family
ID=22872572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE303/73A IE37326B1 (en) | 1972-03-06 | 1973-02-27 | Antihypertensive compositions |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3833727A (OSRAM) |
| AT (1) | AT331966B (OSRAM) |
| BE (1) | BE796288A (OSRAM) |
| CA (1) | CA1015662A (OSRAM) |
| CY (1) | CY951A (OSRAM) |
| DD (1) | DD103559A5 (OSRAM) |
| FR (1) | FR2181786B1 (OSRAM) |
| GB (1) | GB1385648A (OSRAM) |
| HK (1) | HK23378A (OSRAM) |
| HU (1) | HU165714B (OSRAM) |
| IE (1) | IE37326B1 (OSRAM) |
| IL (1) | IL41610A (OSRAM) |
| KE (1) | KE2839A (OSRAM) |
| LU (1) | LU67144A1 (OSRAM) |
| MY (1) | MY7800295A (OSRAM) |
| NL (1) | NL176746C (OSRAM) |
| PH (1) | PH18901A (OSRAM) |
| SE (1) | SE400472B (OSRAM) |
| ZA (1) | ZA731505B (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001421A (en) * | 1971-10-27 | 1977-01-04 | Syntex (U.S.A.) Inc. | Thiazole cardiovascular agents |
| NZ196227A (en) * | 1980-02-19 | 1984-09-28 | Merck & Co Inc | 1,2,5-thiadiazole derivative and ophthalmic compositions |
| US4521414A (en) * | 1981-06-18 | 1985-06-04 | The Texas A&M University System | Ophthalmic compositions and their use for treating elevated intraocular pressure and glaucoma |
| US20110092507A1 (en) * | 2009-10-20 | 2011-04-21 | Chin-Tsai Fan | Process for preparing R-(+)-3-morpholino-4-(3- tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole |
-
1972
- 1972-03-06 US US00232294A patent/US3833727A/en not_active Expired - Lifetime
-
1973
- 1973-02-26 IL IL41610A patent/IL41610A/xx unknown
- 1973-02-27 NL NLAANVRAGE7302728,A patent/NL176746C/xx not_active IP Right Cessation
- 1973-02-27 CA CA164,752A patent/CA1015662A/en not_active Expired
- 1973-02-27 IE IE303/73A patent/IE37326B1/xx unknown
- 1973-03-01 CY CY951A patent/CY951A/xx unknown
- 1973-03-01 GB GB997973A patent/GB1385648A/en not_active Expired
- 1973-03-01 SE SE7302895A patent/SE400472B/xx unknown
- 1973-03-02 LU LU67144A patent/LU67144A1/xx unknown
- 1973-03-05 HU HUME1610A patent/HU165714B/hu unknown
- 1973-03-05 DD DD169223A patent/DD103559A5/xx unknown
- 1973-03-05 BE BE128383A patent/BE796288A/xx not_active IP Right Cessation
- 1973-03-05 ZA ZA731505A patent/ZA731505B/xx unknown
- 1973-03-05 PH PH14393A patent/PH18901A/en unknown
- 1973-03-06 FR FR7307877A patent/FR2181786B1/fr not_active Expired
- 1973-03-06 AT AT195873A patent/AT331966B/de not_active IP Right Cessation
-
1978
- 1978-05-04 HK HK233/78A patent/HK23378A/xx unknown
- 1978-05-15 KE KE2839A patent/KE2839A/xx unknown
- 1978-12-30 MY MY295/78A patent/MY7800295A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1015662A (en) | 1977-08-16 |
| IL41610A0 (en) | 1973-04-30 |
| IE37326L (en) | 1973-09-06 |
| CY951A (en) | 1978-12-22 |
| DE2310836A1 (de) | 1973-09-20 |
| NL176746B (nl) | 1985-01-02 |
| DE2310836B2 (de) | 1976-11-04 |
| ATA195873A (de) | 1975-12-15 |
| AU5266273A (en) | 1974-08-29 |
| HU165714B (OSRAM) | 1974-10-28 |
| IL41610A (en) | 1975-08-31 |
| FR2181786A1 (OSRAM) | 1973-12-07 |
| GB1385648A (en) | 1975-02-26 |
| SE400472B (sv) | 1978-04-03 |
| KE2839A (en) | 1978-05-26 |
| PH18901A (en) | 1985-10-30 |
| BE796288A (fr) | 1973-09-05 |
| NL176746C (nl) | 1985-06-03 |
| US3833727A (en) | 1974-09-03 |
| ZA731505B (en) | 1974-10-30 |
| HK23378A (en) | 1978-05-12 |
| NL7302728A (OSRAM) | 1973-09-10 |
| DD103559A5 (OSRAM) | 1974-02-05 |
| LU67144A1 (OSRAM) | 1973-09-06 |
| AT331966B (de) | 1976-09-10 |
| MY7800295A (en) | 1978-12-31 |
| FR2181786B1 (OSRAM) | 1976-05-14 |
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