IE37158L - 1, 3-diazacycloalkenes - Google Patents

1, 3-diazacycloalkenes

Info

Publication number
IE37158L
IE37158L IE156872A IE156872A IE37158L IE 37158 L IE37158 L IE 37158L IE 156872 A IE156872 A IE 156872A IE 156872 A IE156872 A IE 156872A IE 37158 L IE37158 L IE 37158L
Authority
IE
Ireland
Prior art keywords
lower alkyl
halogen
opt
cpds
organometal
Prior art date
Application number
IE156872A
Other versions
IE37158B1 (en
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB125071*[A external-priority patent/GB1366133A/en
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of IE37158L publication Critical patent/IE37158L/en
Publication of IE37158B1 publication Critical patent/IE37158B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cpds. of formula (where n = 0, 1 or 2; R3 and R4 are same or different H or lower alkyl; or R3 = H and R4 = hydroxy; Ph = phenyl opt. mono- or poly-substd. with hydroxyl, lower alkyl lower alkoxy, halo-lower alkyl, halogen, amino or mono- di(lower)alkylamino; R = hydroxyl, acyloxy, alkoxy or halogen; R1 = opt. substd. phenyl or naphthyl; or R + R1 form together an oxo-group; R6 = H, lower alkyl lower alkenyl or acyl. Acid-addition salts of (I) are included. Prepd. by reacting a cpd. (II) with an organometal cpd. which can convert the ketone function to where R8 = as signified for R1; the reaction is then opt. followed by one or more acylation, displacement, substitution or addition reactions. PRef. organometal cpds. are Grignard reagents R8MgY where Y = halogen, or alkali metal cpds. such as R8Li. Reaction in inert solvent such as ethers. [CH575398A5]
IE156872A 1971-01-11 1972-11-15 Tetrahydropyrimidines imidazolines and tetrahydro-1,3- diazepines IE37158B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB125071*[A GB1366133A (en) 1971-01-11 1971-01-11 Fused ring indole derivatives
GB5646771 1971-12-06
GB1206972 1972-03-15

Publications (2)

Publication Number Publication Date
IE37158L true IE37158L (en) 1973-06-06
IE37158B1 IE37158B1 (en) 1977-05-25

Family

ID=27253858

Family Applications (1)

Application Number Title Priority Date Filing Date
IE156872A IE37158B1 (en) 1971-01-11 1972-11-15 Tetrahydropyrimidines imidazolines and tetrahydro-1,3- diazepines

Country Status (5)

Country Link
AR (1) AR199650A1 (en)
CH (3) CH576450A5 (en)
IE (1) IE37158B1 (en)
NL (1) NL7216545A (en)
PH (1) PH9906A (en)

Also Published As

Publication number Publication date
CH575931A5 (en) 1976-05-31
CH576450A5 (en) 1976-06-15
NL7216545A (en) 1973-06-08
IE37158B1 (en) 1977-05-25
PH9906A (en) 1976-06-08
AR199650A1 (en) 1974-09-23
CH575398A5 (en) 1976-05-14

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