IE36232B1 - Phosphate ester derivatives containing a pyrazolidinyl ring - Google Patents
Phosphate ester derivatives containing a pyrazolidinyl ringInfo
- Publication number
- IE36232B1 IE36232B1 IE405/72A IE40572A IE36232B1 IE 36232 B1 IE36232 B1 IE 36232B1 IE 405/72 A IE405/72 A IE 405/72A IE 40572 A IE40572 A IE 40572A IE 36232 B1 IE36232 B1 IE 36232B1
- Authority
- IE
- Ireland
- Prior art keywords
- free acid
- salt
- water
- solution
- formula
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title 1
- -1 Phosphate ester Chemical class 0.000 title 1
- 239000010452 phosphate Substances 0.000 title 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 7
- 150000003839 salts Chemical class 0.000 abstract 5
- 159000000007 calcium salts Chemical class 0.000 abstract 4
- 239000000243 solution Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000001816 cooling Methods 0.000 abstract 2
- 239000003456 ion exchange resin Substances 0.000 abstract 2
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XBKIVOQPLXPPKF-UHFFFAOYSA-N 1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione Chemical class C1=CC(O)=CC=C1N1C(=O)CC(=O)N1C1=CC=CC=C1 XBKIVOQPLXPPKF-UHFFFAOYSA-N 0.000 abstract 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 abstract 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000011033 desalting Methods 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 abstract 1
- CMPQUABWPXYYSH-UHFFFAOYSA-N phenyl phosphate Chemical class OP(O)(=O)OC1=CC=CC=C1 CMPQUABWPXYYSH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- CYMJPJKHCSDSRG-UHFFFAOYSA-N pyrazolidine-3,4-dione Chemical class O=C1CNNC1=O CYMJPJKHCSDSRG-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 150000004685 tetrahydrates Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT4987771 | 1971-04-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36232L IE36232L (en) | 1972-10-21 |
| IE36232B1 true IE36232B1 (en) | 1976-09-15 |
Family
ID=11271759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE405/72A IE36232B1 (en) | 1971-04-21 | 1972-03-28 | Phosphate ester derivatives containing a pyrazolidinyl ring |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US3803166A (enExample) |
| AR (1) | AR194361A1 (enExample) |
| AU (1) | AU461688B2 (enExample) |
| BE (1) | BE782495A (enExample) |
| CA (1) | CA985691A (enExample) |
| DE (1) | DE2218606A1 (enExample) |
| DK (1) | DK132893C (enExample) |
| ES (1) | ES401952A1 (enExample) |
| FR (1) | FR2133975B1 (enExample) |
| GB (1) | GB1374641A (enExample) |
| IE (1) | IE36232B1 (enExample) |
| IL (1) | IL39097A (enExample) |
| NL (1) | NL7205244A (enExample) |
| PH (1) | PH9791A (enExample) |
| ZA (1) | ZA722068B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050113343A1 (en) * | 2003-10-14 | 2005-05-26 | Pliva - Research And Development Ltd. | Solid-state form of alendronate sodium and preparation thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1814649A1 (de) * | 1968-12-13 | 1970-06-25 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung von 1,2-Diphenyl-3,5-dioxopyrazolidin und dessen Substitutionsprodukten |
-
1972
- 1972-03-24 GB GB1395972A patent/GB1374641A/en not_active Expired
- 1972-03-24 CA CA138,054A patent/CA985691A/en not_active Expired
- 1972-03-27 US US00238554A patent/US3803166A/en not_active Expired - Lifetime
- 1972-03-27 ZA ZA722068A patent/ZA722068B/xx unknown
- 1972-03-28 IE IE405/72A patent/IE36232B1/xx unknown
- 1972-03-28 IL IL39097A patent/IL39097A/en unknown
- 1972-03-28 PH PH13394*A patent/PH9791A/en unknown
- 1972-03-30 AU AU40624/72A patent/AU461688B2/en not_active Expired
- 1972-04-17 DE DE19722218606 patent/DE2218606A1/de active Pending
- 1972-04-18 DK DK189472A patent/DK132893C/da active
- 1972-04-19 NL NL7205244A patent/NL7205244A/xx unknown
- 1972-04-20 FR FR7214037A patent/FR2133975B1/fr not_active Expired
- 1972-04-20 ES ES401952A patent/ES401952A1/es not_active Expired
- 1972-04-21 BE BE782495A patent/BE782495A/xx unknown
- 1972-07-13 AR AR241448A patent/AR194361A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| AR194361A1 (es) | 1973-07-13 |
| CA985691A (en) | 1976-03-16 |
| AU461688B2 (en) | 1975-06-05 |
| BE782495A (fr) | 1972-08-16 |
| IL39097A (en) | 1974-11-29 |
| DK132893B (da) | 1976-02-23 |
| DK132893C (da) | 1976-07-26 |
| ZA722068B (en) | 1972-12-27 |
| PH9791A (en) | 1976-03-17 |
| IE36232L (en) | 1972-10-21 |
| IL39097A0 (en) | 1972-05-30 |
| ES401952A1 (es) | 1975-10-16 |
| AU4062472A (en) | 1973-10-04 |
| FR2133975A1 (enExample) | 1972-12-01 |
| US3803166A (en) | 1974-04-09 |
| FR2133975B1 (enExample) | 1975-10-31 |
| DE2218606A1 (de) | 1972-11-09 |
| NL7205244A (enExample) | 1972-10-24 |
| GB1374641A (en) | 1974-11-20 |
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