IE35434B1 - Benzene derivatives - Google Patents

Benzene derivatives

Info

Publication number
IE35434B1
IE35434B1 IE77571A IE77571A IE35434B1 IE 35434 B1 IE35434 B1 IE 35434B1 IE 77571 A IE77571 A IE 77571A IE 77571 A IE77571 A IE 77571A IE 35434 B1 IE35434 B1 IE 35434B1
Authority
IE
Ireland
Prior art keywords
group
carbon atoms
group containing
straight
branched
Prior art date
Application number
IE77571A
Other versions
IE35434L (en
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of IE35434L publication Critical patent/IE35434L/en
Publication of IE35434B1 publication Critical patent/IE35434B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1307250 Thiourea derivatives MAY & BAKER Ltd 16 June 1971 [16 June 1970 22 June 1970 26 June 1970 4 Sept 1970 21 Oct 1970 11 Dec 1970 25 March 1971 31 March 1971 1 April 1971 (3)] 29259/70 30244/70 31209/70 42609/70 50000/70 59111/70 7850/71 8292/71 8462/71 8463/71 and 8466/71 Heading C2C [Also in Division A5] The invention comprises novel therapeutic and agricultural fungicidal compounds (I) wherein R<SP>5</SP> represents a group (wherein R<SP>7</SP> represents a straight- or branchedchain aliphatic hydrocarbon group containing not more than 4 carbon atoms which may be saturated or unsaturated and which may optionally be substituted by a halogen atom or an alkoxy group containing not more than 4 carbon atoms, and R<SP>8</SP> represents a hydrogen atom or a methyl group), R<SP>6</SP> represents a hydrogen or a halogen atom, or a straight- or branched-chain alkyl group containing not more than 4 carbon atoms, an alkanoylamino group containing 1 to 4 carbon atoms in which the alkanoyl moiety may be straight- or branched-chain and may optionally be substituted by a cycloalkyl group containing from 3 to 6 carbon atoms, an alkoxycarbonylamino group containing from 2 to 4 carbon atoms in which the alkoxy moiety may be straight- or branched-chain, a straight- or branched-chain alkanoyl group containing from 2 to 4 carbon atoms, a benzoyl group or a group and Y represents a group falling within the definition of the symbol R<SP>5</SP>, a nitro group or a group -NR<SP>9</SP>R<SP>10</SP> [wherein R<SP>9</SP> and R<SP>10</SP> each represent a hydrogen atom, or R<SP>9</SP> represents a hydrogen atom or a methyl group and R<SP>10</SP> represents a straight- or branched-chain alkanoyl group containing 1 to 4 carbon atoms (which may optionally be substituted by a cycloalkyl group containing from 3 to 6 carbon atoms), a straight- or branched-chain alkoxycarbonyl group containing 2 to 4 carbon atoms, or a group -COA<SP>1</SP>Z<SP>1</SP>, wherein A<SP>1</SP> represents a straight chain aliphatic hydrocarbon group containing not more than 4 carbon atoms which may be saturated or unsaturated and may optionally be substituted by at least one methyl group, and Z<SP>1</SP> represents a carboxy group or a group of the general formula wherein R<SP>11</SP> represents a hydrogen atom or a straight- or branched-chain alkyl group containing not more than 4 carbon atoms, R<SP>12</SP> represents a hydrogen atom or a straight- or branched-chain alkyl group containing not more than 4 carbon atoms or a phenylalkyl group with 1 or 2 carbon atoms in the alkyl moiety, and R<SP>13</SP> represents a hydrogen atom or a straight- or branched-chain alkyl group containing not more than 4 carbon atoms, or R<SP>12</SP> and R<SP>13</SP> together with the nitrogen atom to which they are attached form a 5-, 6- or 7- membered heterocyclic ring which may contain in the ring one or two further hetero atoms selected from oxygen, nitrogen and sulphur and which may optionally be substituted by one or more C 1 to C 6 alkyl groups and X<SP>2</SP># is an anion] and, where Yis primary amino, acid addition salts thereof, with the provisos that (i) when R<SP>5</SP> and Y each represent a group -N(R<SP>8</SP>)CSNHCOOR<SP>7</SP>, in which R<SP>8</SP> is a hydrogen atom or a methyl group and R<SP>7</SP> is an alkyl group containing not more than 4 carbon atoms, or an alkyl group of ] or 2 carbon atoms substituted by a halogen atom or methoxy group, or an alkenyl or alkynyl group of 2 or 3 carbon atoms, R<SP>6</SP> is other than a hydrogen or halogen atom or a methyl group; or (ii) when R<SP>5</SP> is a group - NHCSNHCOOR<SP>7</SP> in which R<SP>7</SP> is an alkyl group containing not more than 4 carbon atoms, and (a) Y is a group -NR<SP>9</SP>R<SP>10</SP> in which R<SP>9</SP> is a hydrogen atom or a methyl group and R<SP>10</SP> is an alkanoyl group containing 1 to 3 carbon atoms, a cyclopropylcarbonyl group or an alkoxycarbonyl group containing 2 or 3 carbon atoms, R<SP>6</SP> is other than a hydrogen or chlorine atom or a methyl group, or (b) Y is a group -NR<SP>9</SP>R<SP>10</SP> in which R<SP>9</SP> and R<SP>10</SP> each represents a hydrogen atom, R<SP>6</SP> is other than a hydrogen or halogen atom or methyl group; or (iii) when R<SP>5</SP> is a group -NHCSNHCOOR<SP>7</SP> in which R<SP>7</SP> is an alkyl group containing not more than 4 carbon atoms and Y is a nitro group, R<SP>6</SP> is other than a hydrogen or chlorine atom or a methyl group or, when R<SP>6</SP> is in o-position in relation to R<SP>5</SP>, R<SP>6</SP> is additionally other than an alkanoylamino group containing 1 to 3 carbons, a cyclopropyl carbonamido group or an alkoxycarbonylamino group containing 2 or 3 carbons. They are obtained by standard methods utilizing compounds II to XII (X<SP>3</SP> is Br, Cl or I). [GB1307250A]
IE77571A 1970-06-16 1971-06-16 Benzene derivatives IE35434B1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
GB2925970A GB1307250A (en) 1970-06-16 1970-06-16 Benzene derivatives
GB3024470 1970-06-22
GB3120970 1970-06-26
GB4260970 1970-09-04
GB5006070 1970-10-21
GB5911170 1970-12-11
GB785071 1971-03-25
GB829271 1971-03-31
GB846271 1971-04-01
GB846671 1971-04-01
GB846371 1971-04-01

Publications (2)

Publication Number Publication Date
IE35434L IE35434L (en) 1971-12-16
IE35434B1 true IE35434B1 (en) 1976-02-18

Family

ID=27581633

Family Applications (1)

Application Number Title Priority Date Filing Date
IE77571A IE35434B1 (en) 1970-06-16 1971-06-16 Benzene derivatives

Country Status (9)

Country Link
AR (1) AR192765A1 (en)
CA (3) CA976159A (en)
CH (3) CH537698A (en)
CY (1) CY761A (en)
DE (1) DE2129960C2 (en)
FR (1) FR2100764B1 (en)
GB (1) GB1307250A (en)
IE (1) IE35434B1 (en)
NL (1) NL175990C (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310537A (en) * 1976-06-10 1982-01-12 Rohm And Haas Company Acetyl- and carbalkoxythioureidobenzophenones
US4060636A (en) 1976-06-10 1977-11-29 Rohm And Haas Company Acetyl- and carbalkoxythioureidobenzophenones as anthelmintic agents
CH650768A5 (en) * 1982-08-27 1985-08-15 Pharmaton Sa BASIC ACETANILIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE ACETANILIDES.
US4438135A (en) * 1983-01-07 1984-03-20 Smithkline Beckman Corporation 1-(3,4-Bis-(3-(lower alkoxycarbonyl)-2-thioureido)-phenyl-1-phenylthylenes
JPH0253759A (en) * 1988-08-18 1990-02-22 Hamari Yakuhin Kogyo Kk Novel quaternary ammonium compound
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
JP6252009B2 (en) * 2013-07-24 2017-12-27 Jnc株式会社 Novel diamine, polymer using the same, liquid crystal alignment agent, liquid crystal alignment film, and liquid crystal display element
KR20170041662A (en) 2014-06-16 2017-04-17 위니베르시떼 드 릴르 2 드루아 에 상떼 Compounds, Pharmaceutical Composition and Their Use in Treating Neurodegenerative Diseases
DE102016009766A1 (en) * 2016-08-11 2018-02-15 Julius-Maximilians-Universität Würzburg Production of bitter substance derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR96287E (en) * 1967-10-18 1972-06-16
IL30778A (en) * 1967-10-30 1972-10-29 Nippon Soda Co Bis-thioureido-benzenes,their preparation,and fungicidal compositions containing them
CA893141A (en) * 1968-06-18 1972-02-15 Nippon Soda Co., Ltd. Preparation and uses thereof thioureidobenzenes

Also Published As

Publication number Publication date
AR192765A1 (en) 1973-03-14
NL175990B (en) 1984-09-03
IE35434L (en) 1971-12-16
NL175990C (en) 1985-02-01
CY761A (en) 1974-10-31
CH551394A (en) 1974-07-15
CH560186A5 (en) 1975-03-27
GB1307250A (en) 1973-02-14
DE2129960A1 (en) 1971-12-30
NL7108292A (en) 1971-12-20
CA1021695A (en) 1977-11-29
CA1022066A (en) 1977-12-06
FR2100764B1 (en) 1975-01-17
CH537698A (en) 1973-07-31
DE2129960C2 (en) 1982-12-02
FR2100764A1 (en) 1972-03-24
CA976159A (en) 1975-10-14

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