IE35409L - Penicillamine - Google Patents

Penicillamine

Info

Publication number
IE35409L
IE35409L IE710829A IE82971A IE35409L IE 35409 L IE35409 L IE 35409L IE 710829 A IE710829 A IE 710829A IE 82971 A IE82971 A IE 82971A IE 35409 L IE35409 L IE 35409L
Authority
IE
Ireland
Prior art keywords
penicillamine
salt
thiazolidine
converting
iii
Prior art date
Application number
IE710829A
Other versions
IE35409B1 (en
Original Assignee
Degussa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2032952A external-priority patent/DE2032952C3/en
Priority claimed from DE19712123232 external-priority patent/DE2123232C3/en
Application filed by Degussa filed Critical Degussa
Publication of IE35409L publication Critical patent/IE35409L/en
Publication of IE35409B1 publication Critical patent/IE35409B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1346198 Process for penicillamine and its homologues DEUTSCHE GOLD-UND SILBER-SCHEIDEANSTALT 24 June 1971 [3 July 1970 11 May 1971] 29635/71 Heading C2C The invention comprises a process for making penicillamine or a homologue thereof and also salts thereof, by reacting an aliphatic aldehyde, branched on the α-carbon, with sulphur and ammonia to form a #<SP>3</SP>-thiazoline (I), converting (I) by reaction with hydrogen cyanide into a thiazolidine - 4 - carbonitrile (II), converting (II) by mineral acid hydrolysis at below 80‹ C. into a salt of a 4-carbamoylthiazolidine (the free compounds are also described), and thereafter raising the temperature to above 80‹ C. to form a salt of a 4-carboxy-thiazolidine (III) and an ammonium salt (IV); (IV) is removed and (III) or the free acid is hydrolytically degraded to yield the desired product. The following intermediates are also prepared: 2-isopropyl-5,5- dimethylthiazolidine - 4 - carboxylic acid npropyl ester and penicillamine amide hydrochloride; these compounds arise from modifications of the foregoing process. [GB1346198A]
IE829/71A 1970-07-03 1971-06-29 Production of penicillamine and its homologues IE35409B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2032952A DE2032952C3 (en) 1970-07-03 1970-07-03 Process for the preparation of D, L-penicillamine
DE19712123232 DE2123232C3 (en) 1971-05-11 1971-05-11 Process for the preparation of DJ ^ penicillamine

Publications (2)

Publication Number Publication Date
IE35409L true IE35409L (en) 1972-01-03
IE35409B1 IE35409B1 (en) 1976-02-04

Family

ID=25759383

Family Applications (1)

Application Number Title Priority Date Filing Date
IE829/71A IE35409B1 (en) 1970-07-03 1971-06-29 Production of penicillamine and its homologues

Country Status (16)

Country Link
JP (1) JPS544936B1 (en)
AT (2) AT313864B (en)
BE (1) BE769390A (en)
CA (1) CA949977A (en)
CH (1) CH575388A5 (en)
DK (1) DK145180C (en)
ES (1) ES391971A1 (en)
FR (1) FR2100257A5 (en)
GB (1) GB1346198A (en)
IE (1) IE35409B1 (en)
IL (1) IL37171A (en)
IT (1) IT1035036B (en)
NL (1) NL171891C (en)
RO (1) RO59924A (en)
SE (1) SE395001B (en)
SU (1) SU508207A3 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540234A (en) * 1968-09-06 1973-08-15 Degussa Process for the manufacture of penicillamine

Also Published As

Publication number Publication date
ES391971A1 (en) 1974-05-01
SU508207A3 (en) 1976-03-25
IE35409B1 (en) 1976-02-04
GB1346198A (en) 1974-02-06
IT1035036B (en) 1979-10-20
IL37171A (en) 1974-10-22
CA949977A (en) 1974-06-25
AT322523B (en) 1975-05-26
FR2100257A5 (en) 1972-03-17
NL7108503A (en) 1972-01-05
CH575388A5 (en) 1976-05-14
IL37171A0 (en) 1971-08-25
SE395001B (en) 1977-07-25
DK145180B (en) 1982-09-27
DK145180C (en) 1983-02-28
AT313864B (en) 1974-03-11
BE769390A (en) 1972-01-03
JPS544936B1 (en) 1979-03-12
RO59924A (en) 1976-07-15
NL171891B (en) 1983-01-03
NL171891C (en) 1983-06-01

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