IE35369L - Tetrahydropyridine derivatives - Google Patents

Tetrahydropyridine derivatives

Info

Publication number
IE35369L
IE35369L IE710769A IE76971A IE35369L IE 35369 L IE35369 L IE 35369L IE 710769 A IE710769 A IE 710769A IE 76971 A IE76971 A IE 76971A IE 35369 L IE35369 L IE 35369L
Authority
IE
Ireland
Prior art keywords
cycloalkyl
alkyl
compound
compounds
phenyltetrahydropyridine
Prior art date
Application number
IE710769A
Other versions
IE35369B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE35369L publication Critical patent/IE35369L/en
Publication of IE35369B1 publication Critical patent/IE35369B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cleaning In General (AREA)

Abstract

1338056 Tetrahydropyridine derivatives F HOFFMANN-LA ROCHE & CO AG 16 June 1971 [19 June 1970] 28136/71 Heading C2C The invention comprises compounds of formula and their acid addition salts, wherein R<SP>1</SP> is H, alkanoyl, alkylsulphonyl, alkyl, cycloalkyl or cycloalkyl-alkyl, R<SP>2</SP> is H, alkyl, cycloalkyl or cycloalkyl-alkyl, X is O or S, and Y is F, Cl or alkoxy, each of the specified organic radicals containing up to 6 carbon atoms. These compounds may be prepared by (1) condensing together the correspondingly substituted (a) phenoxyethyl or phenylthioethyl compound and phenyltetrahydropyridine, or (b) phenyltetrahydro-1- pyridylethyl compound and p-R<SP>1</SP>R<SP>2</SP>NC 6 H 4 XM (M = alkali metal or Mg-halide); (2) dehydrating the corresponding 4-hydroxypiperidine; (3) treating with mineral acid the corresponding 6-methyl-1,3-oxazine (whereby the oxazine rearranges to the tetrahydropyridine); (4) reducing a corresponding 1-(p-nitrophenoxyethyl- or p-nitrophenylthioethyl)-4-phenyltetrahydropyridine or the 1-(p-aminophenoxyacetyl- or p-aminophenylthioacetyl-), or the 1-(p-nitrophenoxyacetyl- or p - nitrophenylthioacetyl-) analogues; and optionally (5) alkanoylating, alkylsulphonylating, alkylating, cycloalkylating or cycloalkyl-alkylating the amine, or hydrolysing the alkanoylamino compound. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have psychosedative activity. [GB1338056A]
IE769/71A 1970-06-19 1971-06-15 Tetrahydropyridine derivatives and a process for the manufacture thereof IE35369B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH931870A CH547802A (en) 1970-06-19 1970-06-19 PROCESS FOR THE PRODUCTION OF TETRAHYDROPYRIDE DERIVATIVES.

Publications (2)

Publication Number Publication Date
IE35369L true IE35369L (en) 1971-12-19
IE35369B1 IE35369B1 (en) 1976-01-21

Family

ID=4350687

Family Applications (1)

Application Number Title Priority Date Filing Date
IE769/71A IE35369B1 (en) 1970-06-19 1971-06-15 Tetrahydropyridine derivatives and a process for the manufacture thereof

Country Status (16)

Country Link
AT (5) AT309428B (en)
BE (1) BE768689A (en)
CA (1) CA984844A (en)
CH (1) CH547802A (en)
DE (1) DE2128836A1 (en)
DK (1) DK132887C (en)
ES (1) ES392388A1 (en)
FR (1) FR2100797B1 (en)
GB (5) GB1338058A (en)
HU (1) HU162417B (en)
IE (1) IE35369B1 (en)
IL (1) IL36827A (en)
NL (1) NL7108416A (en)
NO (1) NO133548C (en)
SE (1) SE378814B (en)
ZA (1) ZA713032B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4985074A (en) * 1972-12-22 1974-08-15
US4320131A (en) * 1981-03-16 1982-03-16 Mead Johnson & Company N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones and N-[(4-hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones
AU717140B2 (en) * 1996-03-08 2000-03-16 F. Hoffmann-La Roche Ag Use of 4-phenyl-3,6-dihydro-2H-pyridyl derivatives as NMDA receptor subtype blockers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH506525A (en) * 1968-12-24 1971-04-30 Hoffmann La Roche Aromatic ethers

Also Published As

Publication number Publication date
NL7108416A (en) 1971-12-21
AT309428B (en) 1973-08-27
GB1338059A (en) 1973-11-21
FR2100797B1 (en) 1974-08-23
CH547802A (en) 1974-04-11
FR2100797A1 (en) 1972-03-24
DK132887B (en) 1976-02-23
CA984844A (en) 1976-03-02
SE378814B (en) 1975-09-15
ES392388A1 (en) 1973-08-01
GB1338060A (en) 1973-11-21
DE2128836A1 (en) 1971-12-23
AT309432B (en) 1973-08-27
HU162417B (en) 1973-02-28
ZA713032B (en) 1972-01-26
GB1338058A (en) 1973-11-21
DK132887C (en) 1976-07-26
AT309431B (en) 1973-08-27
IE35369B1 (en) 1976-01-21
IL36827A0 (en) 1971-07-28
AT309433B (en) 1973-08-27
AT311971B (en) 1973-12-10
GB1338056A (en) 1973-11-21
NO133548C (en) 1976-05-19
IL36827A (en) 1974-10-22
NO133548B (en) 1976-02-09
BE768689A (en) 1971-12-20
GB1338057A (en) 1973-11-21

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