IE34583B1 - Carboxylic esters of hydroxyphenylalkanolamines - Google Patents

Carboxylic esters of hydroxyphenylalkanolamines

Info

Publication number
IE34583B1
IE34583B1 IE394/70A IE39470A IE34583B1 IE 34583 B1 IE34583 B1 IE 34583B1 IE 394/70 A IE394/70 A IE 394/70A IE 39470 A IE39470 A IE 39470A IE 34583 B1 IE34583 B1 IE 34583B1
Authority
IE
Ireland
Prior art keywords
carbon atoms
cycloalkyl
alkyl
hydrogen
formula
Prior art date
Application number
IE394/70A
Other versions
IE34583L (en
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Priority to IE131/73A priority Critical patent/IE34584B1/en
Publication of IE34583L publication Critical patent/IE34583L/en
Publication of IE34583B1 publication Critical patent/IE34583B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1298771 Sympathomimetic medicines STERLING DRUG Inc 20 March 1970 [1 April 1969] 13690/70 Heading A5B [Also in Division C2] Pharmaceutical compositions having sympathomimetic effects particularly bronchodilator activity being in conventional forms for oral or parenteral administration or in the preferred form as an aerosol inhalant preparation comprise an amino-ester of formulae I or II wherein R is hydrogen (only in formula II), alkyl having 1-4 carbon atoms, or cycloalkyl having 3-6 carbon atoms; R<SP>1</SP> is hydrogen or alkyl having 1-3 carbon atoms; Y is an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, O # cycloalkyl -C n H 2n -C- having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, phenyl -C n H 2n O # -C- wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamine having 1-6 carbon atom groups; and Y<SP>1</SP> and Y<SP>2</SP> are the same or different and are hydrogen or one of the acyl members defined by Y, and wherein in Formula I at least one of Y and Y<SP>1</SP> contains no less than four carbon atoms when R is tert-butyl or cycloalkyl and no less than seven carbon atoms when R is alkyl other than tertbutyl, and in Formula II at least one of Y and Y<SP>1</SP> contains no less than four carbon atoms; or an acid-addition salt thereof and a suitable conventional carrier, and if necessary, a propellant. [GB1298771A]
IE394/70A 1969-04-01 1970-04-01 Carboxylic esters of hydroxyphenylalkanolamines IE34583B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE131/73A IE34584B1 (en) 1969-04-01 1970-04-01 Esters of alpha-aminomethyl-3-(hydroxy or hydroxymethyl)-4-hydroxyphenyl ketones

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81237069A 1969-04-01 1969-04-01

Publications (2)

Publication Number Publication Date
IE34583L IE34583L (en) 1970-10-01
IE34583B1 true IE34583B1 (en) 1975-06-25

Family

ID=25209368

Family Applications (1)

Application Number Title Priority Date Filing Date
IE394/70A IE34583B1 (en) 1969-04-01 1970-04-01 Carboxylic esters of hydroxyphenylalkanolamines

Country Status (17)

Country Link
JP (2) JPS5314544B1 (en)
AT (1) AT300762B (en)
BE (1) BE748178A (en)
CH (1) CH522589A (en)
DE (1) DE2015573C3 (en)
DK (1) DK131459B (en)
ES (1) ES378092A1 (en)
FI (1) FI54796C (en)
FR (1) FR2042295B1 (en)
GB (1) GB1298771A (en)
IE (1) IE34583B1 (en)
IL (2) IL42029A (en)
NL (1) NL171155C (en)
NO (1) NO129903B (en)
PH (2) PH9407A (en)
SE (2) SE381039B (en)
ZA (1) ZA702065B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4138581A (en) 1969-04-01 1979-02-06 Sterling Drugs Inc. 3(Hydroxy or hydroxymethyl)-4(hydroxy)-α-(aminomethyl)benzyl alcohols
US3809714A (en) * 1972-08-31 1974-05-07 Interx Research Corp Novel ester of ((methylamino)methyl) benzyl alcohol
US3868461A (en) * 1972-11-22 1975-02-25 Interx Research Corp Ester of 3,4-dihydroxy-alpha (isopropylamino) methyl benzyl alcohol, composition and anti-asthma use thereof
US4046913A (en) 1973-08-18 1977-09-06 Boehringer Ingelheim Gmbh 1-(M-alkanoyloxy-phenyl)-1-hydroxy-2-(N-lower alkyl-amino)-ethanes and salts thereof
FR2315264A2 (en) * 1974-01-15 1977-01-21 Klinge Co Chem Pharm Fab ACYLATED PHENOLETHANOLAMINES
US3957849A (en) * 1974-09-09 1976-05-18 Zoecon Corporation Cyclopropane esters
US4000315A (en) * 1974-09-09 1976-12-28 Zoecon Corporation Cyclopropane esters for the control of mites
ATE7689T1 (en) 1980-07-09 1984-06-15 Aktiebolaget Draco 1-(DIHYDROXYPHENYL)-2-AMINO-AETHANOL DERIVATIVES, PROCESSES AND MEANS FOR THEIR PREPARATION, AND AGENTS CONTAINING THESE DERIVATIVES.
EP0046144B1 (en) * 1980-07-09 1984-04-11 Aktiebolaget Draco Therapeutically active derivatives of phenylethanol amines
FR2541999B1 (en) * 1983-03-04 1986-09-19 Bristol Myers Co PHENETHANOLAMINES AND THEIR USES
US4614830A (en) * 1985-08-09 1986-09-30 Sterling Drug Inc. Esterification process
IT1229846B (en) * 1989-04-20 1991-09-13 Simes ESTERS OF CATECOLAMINS.
US5011845A (en) * 1990-06-13 1991-04-30 Schering Corporation Cyclic diesters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
US5118683A (en) * 1990-06-13 1992-06-02 Schering Corporation Esters of 4-hydroxy-1,3-benzenedimethanol and compositions and methods employing such compounds
CA2758774C (en) * 2009-04-15 2015-02-03 Research Triangle Institute Monoamine reuptake inhibitors
ES2546492T3 (en) 2010-05-21 2015-09-24 Research Triangle Institute 1-Phenylmorpholine derivatives as hydroxybupropion analogs to treat drug dependence
ES2687095T3 (en) 2010-05-21 2018-10-23 Research Triangle Institute Phenylimorpholins and analogues thereof
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
CN108997261B (en) * 2017-06-07 2022-01-07 东莞市凯法生物医药有限公司 Compound and preparation method and application thereof
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Also Published As

Publication number Publication date
BE748178A (en) 1970-09-28
CH522589A (en) 1972-06-30
DE2015573A1 (en) 1970-10-08
DK131459C (en) 1975-12-08
FI54796B (en) 1978-11-30
SE381039B (en) 1975-11-24
ZA702065B (en) 1971-01-27
IE34583L (en) 1970-10-01
DK131459B (en) 1975-07-21
JPS5314544B1 (en) 1978-05-18
AT300762B (en) 1972-08-10
DE2015573C3 (en) 1978-11-02
FR2042295A1 (en) 1971-02-12
GB1298771A (en) 1972-12-06
FR2042295B1 (en) 1974-06-14
NL171155C (en) 1983-02-16
FI54796C (en) 1979-03-12
NO129903B (en) 1974-06-10
SE413503B (en) 1980-06-02
IL34148A0 (en) 1970-07-19
JPS5414096B1 (en) 1979-06-05
ES378092A1 (en) 1973-01-01
IL34148A (en) 1974-01-14
PH9407A (en) 1975-11-06
DE2015573B2 (en) 1978-03-16
NL7004671A (en) 1970-10-05
PH14377A (en) 1981-06-17
NL171155B (en) 1982-09-16
IL42029A (en) 1974-01-14

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