IE34187L - ß-ADRENOLYTICALLY ACTIVE COMPOSITIONS - Google Patents
ß-ADRENOLYTICALLY ACTIVE COMPOSITIONSInfo
- Publication number
- IE34187L IE34187L IE700439A IE43970A IE34187L IE 34187 L IE34187 L IE 34187L IE 700439 A IE700439 A IE 700439A IE 43970 A IE43970 A IE 43970A IE 34187 L IE34187 L IE 34187L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- hydroxy
- hydroxyalkyl
- those
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1305644 #-Adrenolytic medicines BOEHRINGER INGELHEIM GmbH 16 April 1970 [16 April 1969] 18243/70 Heading A5B Pharmaceutical compositions having improved #-adrenolytic activity comprise a #- receptor blocking agent of the 1-aryloxy-2- hydroxy-3-aminopropane or 1-aryl-1-hydroxy- 2-amino-methane type and a "minor tranquilizer". The #-adrenolyties are those of the general formula: Ar-OCH 2 -CHOH-CH 2 - NHR wherein Ar is an iso-, homo- or heterocyclic group which contains at least one 6- membered aromatic ring linked directly to the remainder of the molecule and which may optionally be substituted by one or more C 1-4 alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl, alkylnyloxy, alkylthio, alkylsuphonyl, hydroxyalkyl, aminoalkyl, alkylamino, dialkylamino, acyl, acyloxy, acylamino, phenyl, phenoxy, phenylamino, phenylthio, phenylsulphonyl, phenylsulphonylamino, benzoylamino, phenalkoxy, haloalkyl, alkoxyalkyl, monoalkylaminoalkyl or dialkylaminoalkyl, nitro, hydroxy, amino, cyano or halogeno groups and R is a C 1-8 alkyl or hydroxyalkyl groups and those of the general formula: Ar 1 -CHOHCHR 1 ,-NHR wherein Ar 1 is a phenyl, naphthyl, tetralyl or indanyl group optionally substituted by halo, nitro, alkyl or alkoxy groups, R is a C 1-8 alkyl or hydroxyalkyl group and R 1 is hydrogen or a C 1-4 alkyl group. Suitable tranquilizers are those which are non-hypnotic and show no antipsychotic effect and include Hydroxyzine, Methylpentynol, Mephenesin, Mephenesin carbamate, Guiaphenesin, Meprobamate, Prenderol, Carisoprodol, Mebutamate, Chlordiazepoxide, Diazepam. Nitrazepam, Medazepam and Oxazepam. The compositions may be in conventional forms for oral, rectal and parenteral administration.
[GB1305644A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691919342 DE1919342A1 (en) | 1969-04-16 | 1969-04-16 | Cardiac active combination preparations |
Publications (2)
Publication Number | Publication Date |
---|---|
IE34187L true IE34187L (en) | 1970-10-16 |
IE34187B1 IE34187B1 (en) | 1975-03-05 |
Family
ID=5731393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE439/70A IE34187B1 (en) | 1969-04-16 | 1970-04-07 | Improvements in compositions having beta-adrenolytic activity |
Country Status (8)
Country | Link |
---|---|
BE (1) | BE748820A (en) |
CA (1) | CA940048A (en) |
DE (1) | DE1919342A1 (en) |
FR (1) | FR2042334B1 (en) |
GB (1) | GB1305644A (en) |
IE (1) | IE34187B1 (en) |
NL (1) | NL7005435A (en) |
ZA (1) | ZA702530B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000282A (en) | 1974-12-16 | 1976-12-28 | Merck & Co., Inc. | 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines |
LU76150A1 (en) * | 1976-11-08 | 1978-07-10 | ||
FR2401661A1 (en) * | 1977-08-29 | 1979-03-30 | Italiana Med Sint | Compsns. for treating anxiety and neurodystonic states - contain a synergistic mixt. of benzodiazepine anxiolytic and beta adrenergic receptor inhibitor |
US4279913A (en) * | 1978-01-04 | 1981-07-21 | Merck & Co., Inc. | Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines |
US4294969A (en) * | 1979-01-29 | 1981-10-13 | Merck & Co., Inc. | Process for producing 2-bromo-3,5-disubstituted pyridines |
DE2926653A1 (en) * | 1979-07-02 | 1981-01-22 | Sandoz Ag | NEW THERAPEUTIC USE OF ORGANIC COMPOUNDS |
US4416735A (en) | 1982-06-17 | 1983-11-22 | Eastman Kodak Company | Diluent and method for potentiometric assay of liquids |
US4468391A (en) * | 1982-06-25 | 1984-08-28 | Ayerst, Mckenna & Harrison, Inc. | Combination of β-adrenoceptor antagonists and anxiolytic agents |
-
1969
- 1969-04-16 DE DE19691919342 patent/DE1919342A1/en active Pending
-
1970
- 1970-04-07 IE IE439/70A patent/IE34187B1/en unknown
- 1970-04-08 CA CA079,531A patent/CA940048A/en not_active Expired
- 1970-04-10 BE BE748820D patent/BE748820A/en unknown
- 1970-04-15 ZA ZA702530A patent/ZA702530B/en unknown
- 1970-04-15 NL NL7005435A patent/NL7005435A/xx unknown
- 1970-04-16 GB GB1824370A patent/GB1305644A/en not_active Expired
- 1970-04-16 FR FR7013780A patent/FR2042334B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2042334A1 (en) | 1971-02-12 |
FR2042334B1 (en) | 1974-08-30 |
DE1919342A1 (en) | 1970-12-03 |
GB1305644A (en) | 1973-02-07 |
ZA702530B (en) | 1971-01-27 |
BE748820A (en) | 1970-10-12 |
IE34187B1 (en) | 1975-03-05 |
NL7005435A (en) | 1970-10-20 |
CA940048A (en) | 1974-01-15 |
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