IE33924L - 11beta-chloro-19-nor-steroids - Google Patents

11beta-chloro-19-nor-steroids

Info

Publication number
IE33924L
IE33924L IE690105A IE10569A IE33924L IE 33924 L IE33924 L IE 33924L IE 690105 A IE690105 A IE 690105A IE 10569 A IE10569 A IE 10569A IE 33924 L IE33924 L IE 33924L
Authority
IE
Ireland
Prior art keywords
pyrazolino
steroids
chloro
activity
methylene
Prior art date
Application number
IE690105A
Other versions
IE33924B1 (en
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of IE33924L publication Critical patent/IE33924L/en
Publication of IE33924B1 publication Critical patent/IE33924B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/0035—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a hydroxy group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
    • C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,260,465. Compositions comprising steroids. GLAXO LABORATORIES Ltd. 23 Jan., 1969 [29 Jan., 1968], No. 4570/68. Heading A5B. [Also in Division C2] Pharmaceutical and veterinary compositions having hormonal activity, particularly progestational and anti-estrogenic activity with or without anti-androgenic activity, contain 9α- unsubstituted 11#-chloro-19-nor-steroids having the following structure in the D-ring where R<SP>1</SP> is -COCH 3 ; R<SP>2</SP> is H, OH or acyloxy; R<SP>3</SP> is OCH 3 ; or R<SP>2</SP>+R<SP>3</SP> is a carboncarbon bond or an epoxy or methylene group, or R<SP>2</SP>, R<SP>3</SP> and the adjacent C atom form a 1'-pyrazolino-(4', 3':16α, 17α)- or 2'-pyrazolino-(4', 5':16α, 17α)-grouping; and R<SP>4</SP> is H or CH 3 but is not CH 3 when 16, 17-methylene or -pyrazolino is present, and, optionally, further compounds possessing hormonal activity, particularly estrogens. Oral tablets containing 17α-acetoxy-11#-chloro-16-methylene-19-nor-pregn-4-ene-3, 20-dione and ethynyl estradiol are among the specified compositions, which may be used inter alia, as contraceptives. [GB1260465A]
IE105/69A 1968-01-29 1969-01-27 11beta -chloro-19-nor-steroids IE33924B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4570/68A GB1260465A (en) 1968-01-29 1968-01-29 11beta-CHLORO-19-NOR-STEROIDS

Publications (2)

Publication Number Publication Date
IE33924L true IE33924L (en) 1969-07-29
IE33924B1 IE33924B1 (en) 1974-12-11

Family

ID=9779640

Family Applications (1)

Application Number Title Priority Date Filing Date
IE105/69A IE33924B1 (en) 1968-01-29 1969-01-27 11beta -chloro-19-nor-steroids

Country Status (14)

Country Link
JP (2) JPS4828907B1 (en)
AT (1) AT309703B (en)
BE (1) BE727578A (en)
BR (1) BR6905985D0 (en)
CH (2) CH592688A5 (en)
DE (1) DE1904325C3 (en)
DK (1) DK128715B (en)
ES (1) ES363068A1 (en)
FR (1) FR2000924A1 (en)
GB (1) GB1260465A (en)
IE (1) IE33924B1 (en)
IL (1) IL31515A0 (en)
NL (1) NL6901342A (en)
SE (2) SE364267B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52119945U (en) * 1976-03-08 1977-09-12
US5710293A (en) * 1995-10-13 1998-01-20 The Population Council, Center For Biomedical Research Method of preparation of ester derivatives of steroids

Also Published As

Publication number Publication date
BE727578A (en) 1969-07-29
BR6905985D0 (en) 1973-04-19
GB1260465A (en) 1972-01-19
JPS4830051B1 (en) 1973-09-17
DE1904325C3 (en) 1978-10-26
DK128715B (en) 1974-06-24
AT309703B (en) 1973-08-27
CH578017A5 (en) 1976-07-30
NL6901342A (en) 1969-07-31
CH592688A5 (en) 1977-11-15
ES363068A1 (en) 1971-06-16
FR2000924A1 (en) 1969-09-19
DE1904325A1 (en) 1969-09-04
IL31515A0 (en) 1969-03-27
IE33924B1 (en) 1974-12-11
JPS4828907B1 (en) 1973-09-05
SE364267B (en) 1974-02-18
DE1904325B2 (en) 1978-02-16
SE386903B (en) 1976-08-23

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