IE32664B1 - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- IE32664B1 IE32664B1 IE306/69A IE30669A IE32664B1 IE 32664 B1 IE32664 B1 IE 32664B1 IE 306/69 A IE306/69 A IE 306/69A IE 30669 A IE30669 A IE 30669A IE 32664 B1 IE32664 B1 IE 32664B1
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- acylating
- polymer
- march
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F212/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring
- C08F212/02—Monomers containing only one unsaturated aliphatic radical
- C08F212/04—Monomers containing only one unsaturated aliphatic radical containing one ring
- C08F212/14—Monomers containing only one unsaturated aliphatic radical containing one ring substituted by heteroatoms or groups containing heteroatoms
- C08F212/22—Oxygen
- C08F212/24—Phenols or alcohols
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/10—Acylation
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
- C08F2800/20—Copolymer characterised by the proportions of the comonomers expressed as weight or mass percentages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cephalosporin Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,268,631. N-Acylating 6-amino-penicillin. YEDA RESEARCH & DEVELOPMENT CO. Ltd. 17 March, 1969 [21 March, 1968], No. 13840/68. Heading C2A. [Also in Division C3] A process for N-acylating 6-amino-penicillanic acid comprises contacting a solution of the said acid or a salt, ester, amide or other functional derivative thereof with a solid acylating polymer insoluble in the solution and comprising recurring groups of formula -BRCO wherein RCO is an organic acyl group and B is an activated group, separating solid material from the solution and recovering from the solution the corresponding N-acylated penicillin derivative, optionally as a non-toxic salt. The polymer consists of a series of repeating groups of formula wherein A is the repeating unit of a synthetic or natural polymeric chain. It is prepared by acylating a suitable polymer e.g. poly-(4-hydroxy-3-nitro)-styrene, or a polymer of N- hydroxy-maleimide which may be co-polymerized with ethylene (see Division C3). The inventive reaction may be performed in aqueous or non-aqueous solution and the product recovered by evaporation, extraction or lyophilization. Examples are given for preparing benzyl-; 2,6- dimethoxyphenyl-, 3 - (2 - chlorophenyl) - 5 - methyl-4-isoxazoloyl-; phenoxyethyl-; and carboxy benzyl-penicillins.
[GB1268631A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB03840/68A GB1268631A (en) | 1968-03-21 | 1968-03-21 | Penicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32664L IE32664L (en) | 1969-09-21 |
| IE32664B1 true IE32664B1 (en) | 1973-10-17 |
Family
ID=10030313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE306/69A IE32664B1 (en) | 1968-03-21 | 1969-03-07 | Penicillins |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS4948436B1 (en) |
| AT (1) | AT285816B (en) |
| BE (1) | BE730272A (en) |
| BR (1) | BR6907214D0 (en) |
| CH (1) | CH537414A (en) |
| CS (1) | CS154638B2 (en) |
| DE (1) | DE1913486A1 (en) |
| DK (1) | DK131861C (en) |
| ES (1) | ES364962A1 (en) |
| FI (1) | FI50424C (en) |
| FR (1) | FR2035797B1 (en) |
| GB (1) | GB1268631A (en) |
| IE (1) | IE32664B1 (en) |
| IL (1) | IL31807A (en) |
| NL (1) | NL6904041A (en) |
| PL (1) | PL79945B1 (en) |
| SE (1) | SE359094B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE794118A (en) * | 1972-01-18 | 1973-07-16 | Yeda Research And Dev Cy Ltd | CARBOXYLIC ACID ACYLATION PROCESS |
-
1968
- 1968-03-21 GB GB03840/68A patent/GB1268631A/en not_active Expired
-
1969
- 1969-03-07 IE IE306/69A patent/IE32664B1/en unknown
- 1969-03-13 IL IL31807A patent/IL31807A/en unknown
- 1969-03-14 NL NL6904041A patent/NL6904041A/xx unknown
- 1969-03-17 DE DE19691913486 patent/DE1913486A1/en active Pending
- 1969-03-17 BR BR207214/69A patent/BR6907214D0/en unknown
- 1969-03-18 ES ES364962A patent/ES364962A1/en not_active Expired
- 1969-03-18 SE SE03761/69A patent/SE359094B/xx unknown
- 1969-03-19 CH CH417269A patent/CH537414A/en not_active IP Right Cessation
- 1969-03-19 DK DK150069A patent/DK131861C/en active
- 1969-03-19 AT AT272269A patent/AT285816B/en not_active IP Right Cessation
- 1969-03-20 CS CS200069A patent/CS154638B2/cs unknown
- 1969-03-20 FR FR6908017A patent/FR2035797B1/fr not_active Expired
- 1969-03-20 JP JP44020797A patent/JPS4948436B1/ja active Pending
- 1969-03-20 PL PL1969132469A patent/PL79945B1/pl unknown
- 1969-03-20 FI FI690816A patent/FI50424C/en active
- 1969-03-21 BE BE730272D patent/BE730272A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6907214D0 (en) | 1973-03-13 |
| IL31807A (en) | 1973-03-30 |
| FR2035797B1 (en) | 1974-01-11 |
| IE32664L (en) | 1969-09-21 |
| DK131861B (en) | 1975-09-15 |
| CS154638B2 (en) | 1974-04-30 |
| BE730272A (en) | 1969-09-01 |
| SE359094B (en) | 1973-08-20 |
| DK131861C (en) | 1976-03-22 |
| FI50424C (en) | 1976-03-10 |
| GB1268631A (en) | 1972-03-29 |
| NL6904041A (en) | 1969-09-23 |
| FI50424B (en) | 1975-12-01 |
| DE1913486A1 (en) | 1969-10-30 |
| AT285816B (en) | 1970-11-10 |
| ES364962A1 (en) | 1971-02-16 |
| FR2035797A1 (en) | 1970-12-24 |
| JPS4948436B1 (en) | 1974-12-21 |
| PL79945B1 (en) | 1975-08-30 |
| CH537414A (en) | 1973-05-31 |
| IL31807A0 (en) | 1969-05-28 |
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