IE32004B1 - Pyrazine derivatives and their preparation - Google Patents
Pyrazine derivatives and their preparationInfo
- Publication number
- IE32004B1 IE32004B1 IE377/68A IE37768A IE32004B1 IE 32004 B1 IE32004 B1 IE 32004B1 IE 377/68 A IE377/68 A IE 377/68A IE 37768 A IE37768 A IE 37768A IE 32004 B1 IE32004 B1 IE 32004B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- phenyl
- halophenyl
- atom
- heterocyclic ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63052167A | 1967-04-13 | 1967-04-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32004L IE32004L (en) | 1968-10-13 |
| IE32004B1 true IE32004B1 (en) | 1973-03-07 |
Family
ID=24527511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE377/68A IE32004B1 (en) | 1967-04-13 | 1968-04-02 | Pyrazine derivatives and their preparation |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3527758A (en:Method) |
| AT (1) | AT281064B (en:Method) |
| BE (1) | BE713471A (en:Method) |
| CH (1) | CH512497A (en:Method) |
| DE (1) | DE1770174A1 (en:Method) |
| ES (1) | ES352666A1 (en:Method) |
| FR (1) | FR1559541A (en:Method) |
| GB (1) | GB1185408A (en:Method) |
| IE (1) | IE32004B1 (en:Method) |
| IL (1) | IL29735A (en:Method) |
| NL (1) | NL6804247A (en:Method) |
| SE (1) | SE354865B (en:Method) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894376A (en) * | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
| TW213903B (en:Method) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg | |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| EP2617709B8 (en) | 2003-06-26 | 2022-12-21 | Biotron Limited | Guanidine derivatives as antiviral agents |
| KR20060060027A (ko) * | 2003-08-18 | 2006-06-02 | 패리온 사이언스 인코퍼레이티드 | 캡핑된 피라지노일구아니딘 나트륨 채널 차단제 |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| HUE032891T2 (hu) | 2012-12-17 | 2017-11-28 | Parion Sciences Inc | Klórpirazin-karboxamid-származékok nem kielégítõ nyálkahártya-hidratáció által elõsegített megbetegedések kezelésére |
| CN104995178B (zh) | 2012-12-17 | 2018-06-26 | 帕里昂科学公司 | 3，5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物 |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
-
1967
- 1967-04-13 US US630521A patent/US3527758A/en not_active Expired - Lifetime
-
1968
- 1968-03-26 NL NL6804247A patent/NL6804247A/xx unknown
- 1968-04-01 IL IL29735A patent/IL29735A/xx unknown
- 1968-04-02 IE IE377/68A patent/IE32004B1/xx unknown
- 1968-04-04 SE SE04523/68A patent/SE354865B/xx unknown
- 1968-04-08 AT AT343168A patent/AT281064B/de not_active IP Right Cessation
- 1968-04-08 GB GB06833/68A patent/GB1185408A/en not_active Expired
- 1968-04-08 CH CH518468A patent/CH512497A/de not_active IP Right Cessation
- 1968-04-10 BE BE713471D patent/BE713471A/xx unknown
- 1968-04-10 DE DE19681770174 patent/DE1770174A1/de active Pending
- 1968-04-10 ES ES352666A patent/ES352666A1/es not_active Expired
- 1968-04-12 FR FR1559541D patent/FR1559541A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6804247A (en:Method) | 1968-10-14 |
| BE713471A (en:Method) | 1968-10-10 |
| SE354865B (en:Method) | 1973-03-26 |
| GB1185408A (en) | 1970-03-25 |
| ES352666A1 (es) | 1970-01-01 |
| IL29735A (en) | 1971-08-25 |
| IE32004L (en) | 1968-10-13 |
| CH512497A (de) | 1971-09-15 |
| FR1559541A (en:Method) | 1969-03-07 |
| US3527758A (en) | 1970-09-08 |
| DE1770174A1 (de) | 1971-09-23 |
| AT281064B (de) | 1970-05-11 |
| IL29735A0 (en) | 1968-06-20 |
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