AT281064B - Verfahren zur Herstellung von Pyrazinoylguanidinen und ihren Säureadditionssalzen - Google Patents
Verfahren zur Herstellung von Pyrazinoylguanidinen und ihren SäureadditionssalzenInfo
- Publication number
- AT281064B AT281064B AT343168A AT343168A AT281064B AT 281064 B AT281064 B AT 281064B AT 343168 A AT343168 A AT 343168A AT 343168 A AT343168 A AT 343168A AT 281064 B AT281064 B AT 281064B
- Authority
- AT
- Austria
- Prior art keywords
- pyrazinoylguanidines
- preparation
- acid addition
- addition salts
- salts
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- WNBSDCKJFDZMHT-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide Chemical class NC(N)=NC(=O)C1=CN=CC=N1 WNBSDCKJFDZMHT-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63052167A | 1967-04-13 | 1967-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT281064B true AT281064B (de) | 1970-05-11 |
Family
ID=24527511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT343168A AT281064B (de) | 1967-04-13 | 1968-04-08 | Verfahren zur Herstellung von Pyrazinoylguanidinen und ihren Säureadditionssalzen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3527758A (de) |
| AT (1) | AT281064B (de) |
| BE (1) | BE713471A (de) |
| CH (1) | CH512497A (de) |
| DE (1) | DE1770174A1 (de) |
| ES (1) | ES352666A1 (de) |
| FR (1) | FR1559541A (de) |
| GB (1) | GB1185408A (de) |
| IE (1) | IE32004B1 (de) |
| IL (1) | IL29735A (de) |
| NL (1) | NL6804247A (de) |
| SE (1) | SE354865B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894376A (en) * | 1988-02-26 | 1990-01-16 | Trustees Of The University Of Pennsylvania | Methods of treating diseases characterized by hyperexcitability of neurons |
| TW213903B (de) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg | |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6903105B2 (en) | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| KR101153254B1 (ko) | 2003-06-26 | 2012-07-02 | 바이오트론 리미티드 | 항바이러스 화합물 및 방법 |
| PT1663235E (pt) * | 2003-08-18 | 2013-10-29 | Parion Sciences Inc | Novos bloqueadores dos canais do sódio de pirazinoílguanidina protegida |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| KR20150095870A (ko) | 2012-12-17 | 2015-08-21 | 패리온 사이언스 인코퍼레이티드 | 3,5-디아미노-6-클로로-n-(n-(4-페닐부틸)카르밤이미도일)피라진-2-카르복스아미드 화합물 |
| AU2013363218B2 (en) | 2012-12-17 | 2018-03-15 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
-
1967
- 1967-04-13 US US630521A patent/US3527758A/en not_active Expired - Lifetime
-
1968
- 1968-03-26 NL NL6804247A patent/NL6804247A/xx unknown
- 1968-04-01 IL IL29735A patent/IL29735A/xx unknown
- 1968-04-02 IE IE377/68A patent/IE32004B1/xx unknown
- 1968-04-04 SE SE04523/68A patent/SE354865B/xx unknown
- 1968-04-08 CH CH518468A patent/CH512497A/de not_active IP Right Cessation
- 1968-04-08 AT AT343168A patent/AT281064B/de not_active IP Right Cessation
- 1968-04-08 GB GB06833/68A patent/GB1185408A/en not_active Expired
- 1968-04-10 ES ES352666A patent/ES352666A1/es not_active Expired
- 1968-04-10 BE BE713471D patent/BE713471A/xx unknown
- 1968-04-10 DE DE19681770174 patent/DE1770174A1/de active Pending
- 1968-04-12 FR FR1559541D patent/FR1559541A/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1770174A1 (de) | 1971-09-23 |
| BE713471A (de) | 1968-10-10 |
| IE32004B1 (en) | 1973-03-07 |
| NL6804247A (de) | 1968-10-14 |
| CH512497A (de) | 1971-09-15 |
| SE354865B (de) | 1973-03-26 |
| IL29735A (en) | 1971-08-25 |
| IL29735A0 (en) | 1968-06-20 |
| IE32004L (en) | 1968-10-13 |
| US3527758A (en) | 1970-09-08 |
| ES352666A1 (es) | 1970-01-01 |
| GB1185408A (en) | 1970-03-25 |
| FR1559541A (de) | 1969-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |