HUT62277A - Process for producing 2,3-dihydro-2-imino-l-aryl-3-thiazoleethanol derivatives - Google Patents
Process for producing 2,3-dihydro-2-imino-l-aryl-3-thiazoleethanol derivativesInfo
- Publication number
- HUT62277A HUT62277A HU70992A HU70992A HUT62277A HU T62277 A HUT62277 A HU T62277A HU 70992 A HU70992 A HU 70992A HU 70992 A HU70992 A HU 70992A HU T62277 A HUT62277 A HU T62277A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- aryl
- halo
- optionally substituted
- derivatives
- Prior art date
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Imidazothiazole derivatives of formula (I), their acid addition salts and stereoisomers are new. Ar = phenyl (optionally substituted by 1-3 of halo, OH, 1-6C alkoxy, SH, 1-6C alkyl, 1-6C alkylthio, NO2, NH2, mono- and di(1-6C alkyl)amino, 1-6C alkylcarbonylamino, arylcarbonylamino, 1-6C alkylsulphonylamino, -CF3, CN, aminocarbonyl, mono- and di(1-6C alkyl)aminocarbonyl, COOH, 1-6C alkoxycarbonyl, CHO and CH2OH; pyridinyl, thienyl or furanyl (optionally substituted by 1-6C alkyl or halo). R1, R2 = independently 1-20 C alkyl, (3-7C cycloalkyl)-1-6C alkyl, 3-7C cycloalkyl, aryl or (aryl)-1-6C alkyl, and 1 or R1 and R2 may also be H, or R1 and R2 may form 3-6C alkanediyl. aryl = phenyl optionally substituted by 1-3 of halo, OH, 1-6C alkoxy, 1-6C alkyl, NO2, NH2, CF3 or CN. - 4 compounds are specifically claimed, e.g. 6-(4-bromophenyl)-2-hexyl -5, 6-dihydroimidazo(2, 1-b) -thiazole. Also claimed is the preparation of (I) which comprises e.g. cyclising a corresponding imidazoline with a reagent of formula R1-CH(W1)-C(=O)-R2 in inert solvent. W1 = a reactive leaving group. Dose is 0.01-5 (0.04-25) mg/kg.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44084289A | 1989-11-24 | 1989-11-24 | |
HU907633A HU206361B (en) | 1989-11-24 | 1990-11-23 | Process for producing 6-aryl-5,6-dihydroimidazo(2,1-b)thiazole derivatives and pharmaceutical compositions comprising same |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9200709D0 HU9200709D0 (en) | 1992-05-28 |
HUT62277A true HUT62277A (en) | 1993-04-28 |
Family
ID=26317908
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU70792A HUT62276A (en) | 1989-11-24 | 1990-11-23 | Process for producing 2-(2,3)-dihydro-2-imino-3-thiazolyl)-1-arylethanone derivatives |
HU70992A HUT62277A (en) | 1989-11-24 | 1990-11-23 | Process for producing 2,3-dihydro-2-imino-l-aryl-3-thiazoleethanol derivatives |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU70792A HUT62276A (en) | 1989-11-24 | 1990-11-23 | Process for producing 2-(2,3)-dihydro-2-imino-3-thiazolyl)-1-arylethanone derivatives |
Country Status (1)
Country | Link |
---|---|
HU (2) | HUT62276A (en) |
-
1990
- 1990-11-23 HU HU70792A patent/HUT62276A/en unknown
- 1990-11-23 HU HU70992A patent/HUT62277A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU9200707D0 (en) | 1992-05-28 |
HU9200709D0 (en) | 1992-05-28 |
HUT62276A (en) | 1993-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFD9 | Temporary prot. cancelled due to non-payment of fee |