HUT61524A - Process for producing 1,2,4-substituted pyrrolidine derivatives - Google Patents

Process for producing 1,2,4-substituted pyrrolidine derivatives

Info

Publication number
HUT61524A
HUT61524A HU385091D HU385091D HUT61524A HU T61524 A HUT61524 A HU T61524A HU 385091 D HU385091 D HU 385091D HU 385091 D HU385091 D HU 385091D HU T61524 A HUT61524 A HU T61524A
Authority
HU
Hungary
Prior art keywords
alkyl
producing
pyrrolidine derivatives
substituted pyrrolidine
halo
Prior art date
Application number
HU385091D
Other languages
Hungarian (hu)
Inventor
Tamim Fehme Braish
Darrell Eugene Fox
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/423,063 external-priority patent/US5036153A/en
Application filed by Pfizer filed Critical Pfizer
Publication of HUT61524A publication Critical patent/HUT61524A/en

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Prepn. of (1S,4S)-2-Y-S-R1- 2,5-diazabicylo (2.2.1)heptane derivs. of formula (I) or their enantiomers, racemates or acid addn. salts comprises (a) reacting a pyrrolidine deriv. of formula (III), or its enantiomer or racemate, with H2NQ(V) to give (I; Y = XR2) and, if necessary, (b) reducing, or hydrolysing, to give (I; Y =H). - (Where Y = H or XR2; R1 = H or 1-6C alkyl; X = SO2 or COO; R2 and R3 = 1-6C alkyl, CF3, benzyl or phenyl (opt. substd. by 1-2 of 1-6C alkyl, halo, NO2, OMe or CF3); R4 = halo or OSO2R3; Q = H or 1-6C alkyl).
HU385091D 1989-05-11 1990-05-10 Process for producing 1,2,4-substituted pyrrolidine derivatives HUT61524A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35042389A 1989-05-11 1989-05-11
US07/423,063 US5036153A (en) 1989-05-11 1989-10-18 Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
HU902994A HU206718B (en) 1989-05-11 1990-05-10 Process for producing new diazabicyclo-heptanes

Publications (1)

Publication Number Publication Date
HUT61524A true HUT61524A (en) 1993-01-28

Family

ID=27270007

Family Applications (4)

Application Number Title Priority Date Filing Date
HU385091D HUT61524A (en) 1989-05-11 1990-05-10 Process for producing 1,2,4-substituted pyrrolidine derivatives
HU385291A HUT61525A (en) 1989-05-11 1990-05-10 Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives
HU385391A HUT61526A (en) 1989-05-11 1990-05-10 Process for producing substituted 4-hydroxy-l-proline derivatives
HU385091A HUT61523A (en) 1989-05-11 1990-05-10 Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives

Family Applications After (3)

Application Number Title Priority Date Filing Date
HU385291A HUT61525A (en) 1989-05-11 1990-05-10 Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives
HU385391A HUT61526A (en) 1989-05-11 1990-05-10 Process for producing substituted 4-hydroxy-l-proline derivatives
HU385091A HUT61523A (en) 1989-05-11 1990-05-10 Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives

Country Status (1)

Country Link
HU (4) HUT61524A (en)

Also Published As

Publication number Publication date
HUT61526A (en) 1993-01-28
HUT61525A (en) 1993-01-28
HU913852D0 (en) 1992-02-28
HUT61523A (en) 1993-01-28
HU913850D0 (en) 1992-02-28
HU913853D0 (en) 1992-02-28

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary prot. due to refusal