HUT61526A - Process for producing substituted 4-hydroxy-l-proline derivatives - Google Patents
Process for producing substituted 4-hydroxy-l-proline derivativesInfo
- Publication number
- HUT61526A HUT61526A HU385391A HU385391A HUT61526A HU T61526 A HUT61526 A HU T61526A HU 385391 A HU385391 A HU 385391A HU 385391 A HU385391 A HU 385391A HU T61526 A HUT61526 A HU T61526A
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- hydroxy
- proline derivatives
- producing substituted
- halo
- Prior art date
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Prepn. of (1S,4S)-2-Y-S-R1- 2,5-diazabicylo (2.2.1)heptane derivs. of formula (I) or their enantiomers, racemates or acid addn. salts comprises (a) reacting a pyrrolidine deriv. of formula (III), or its enantiomer or racemate, with H2NQ(V) to give (I; Y = XR2) and, if necessary, (b) reducing, or hydrolysing, to give (I; Y =H). - (Where Y = H or XR2; R1 = H or 1-6C alkyl; X = SO2 or COO; R2 and R3 = 1-6C alkyl, CF3, benzyl or phenyl (opt. substd. by 1-2 of 1-6C alkyl, halo, NO2, OMe or CF3); R4 = halo or OSO2R3; Q = H or 1-6C alkyl).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35042389A | 1989-05-11 | 1989-05-11 | |
US07/423,063 US5036153A (en) | 1989-05-11 | 1989-10-18 | Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates |
HU902994A HU206718B (en) | 1989-05-11 | 1990-05-10 | Process for producing new diazabicyclo-heptanes |
Publications (2)
Publication Number | Publication Date |
---|---|
HU913853D0 HU913853D0 (en) | 1992-02-28 |
HUT61526A true HUT61526A (en) | 1993-01-28 |
Family
ID=27270007
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU385291A HUT61525A (en) | 1989-05-11 | 1990-05-10 | Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives |
HU385091A HUT61523A (en) | 1989-05-11 | 1990-05-10 | Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives |
HU385091D HUT61524A (en) | 1989-05-11 | 1990-05-10 | Process for producing 1,2,4-substituted pyrrolidine derivatives |
HU385391A HUT61526A (en) | 1989-05-11 | 1990-05-10 | Process for producing substituted 4-hydroxy-l-proline derivatives |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU385291A HUT61525A (en) | 1989-05-11 | 1990-05-10 | Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives |
HU385091A HUT61523A (en) | 1989-05-11 | 1990-05-10 | Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives |
HU385091D HUT61524A (en) | 1989-05-11 | 1990-05-10 | Process for producing 1,2,4-substituted pyrrolidine derivatives |
Country Status (1)
Country | Link |
---|---|
HU (4) | HUT61525A (en) |
-
1990
- 1990-05-10 HU HU385291A patent/HUT61525A/en unknown
- 1990-05-10 HU HU385091A patent/HUT61523A/en unknown
- 1990-05-10 HU HU385091D patent/HUT61524A/en unknown
- 1990-05-10 HU HU385391A patent/HUT61526A/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUT61523A (en) | 1993-01-28 |
HUT61524A (en) | 1993-01-28 |
HU913852D0 (en) | 1992-02-28 |
HU913853D0 (en) | 1992-02-28 |
HU913850D0 (en) | 1992-02-28 |
HUT61525A (en) | 1993-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFC4 | Cancellation of temporary prot. due to refusal |