HUT61526A - Process for producing substituted 4-hydroxy-l-proline derivatives - Google Patents

Process for producing substituted 4-hydroxy-l-proline derivatives

Info

Publication number
HUT61526A
HUT61526A HU385391A HU385391A HUT61526A HU T61526 A HUT61526 A HU T61526A HU 385391 A HU385391 A HU 385391A HU 385391 A HU385391 A HU 385391A HU T61526 A HUT61526 A HU T61526A
Authority
HU
Hungary
Prior art keywords
alkyl
hydroxy
proline derivatives
producing substituted
halo
Prior art date
Application number
HU385391A
Other languages
Hungarian (hu)
Other versions
HU913853D0 (en
Inventor
Tamim Fehme Braish
Darrell Eugene Fox
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/423,063 external-priority patent/US5036153A/en
Application filed by Pfizer filed Critical Pfizer
Publication of HU913853D0 publication Critical patent/HU913853D0/en
Publication of HUT61526A publication Critical patent/HUT61526A/en

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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Prepn. of (1S,4S)-2-Y-S-R1- 2,5-diazabicylo (2.2.1)heptane derivs. of formula (I) or their enantiomers, racemates or acid addn. salts comprises (a) reacting a pyrrolidine deriv. of formula (III), or its enantiomer or racemate, with H2NQ(V) to give (I; Y = XR2) and, if necessary, (b) reducing, or hydrolysing, to give (I; Y =H). - (Where Y = H or XR2; R1 = H or 1-6C alkyl; X = SO2 or COO; R2 and R3 = 1-6C alkyl, CF3, benzyl or phenyl (opt. substd. by 1-2 of 1-6C alkyl, halo, NO2, OMe or CF3); R4 = halo or OSO2R3; Q = H or 1-6C alkyl).
HU385391A 1989-05-11 1990-05-10 Process for producing substituted 4-hydroxy-l-proline derivatives HUT61526A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35042389A 1989-05-11 1989-05-11
US07/423,063 US5036153A (en) 1989-05-11 1989-10-18 Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
HU902994A HU206718B (en) 1989-05-11 1990-05-10 Process for producing new diazabicyclo-heptanes

Publications (2)

Publication Number Publication Date
HU913853D0 HU913853D0 (en) 1992-02-28
HUT61526A true HUT61526A (en) 1993-01-28

Family

ID=27270007

Family Applications (4)

Application Number Title Priority Date Filing Date
HU385291A HUT61525A (en) 1989-05-11 1990-05-10 Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives
HU385091A HUT61523A (en) 1989-05-11 1990-05-10 Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives
HU385091D HUT61524A (en) 1989-05-11 1990-05-10 Process for producing 1,2,4-substituted pyrrolidine derivatives
HU385391A HUT61526A (en) 1989-05-11 1990-05-10 Process for producing substituted 4-hydroxy-l-proline derivatives

Family Applications Before (3)

Application Number Title Priority Date Filing Date
HU385291A HUT61525A (en) 1989-05-11 1990-05-10 Process for producing 1,4-substituted-2-hydroxymethylpyrrolidine derivatives
HU385091A HUT61523A (en) 1989-05-11 1990-05-10 Process for producing 2-chloromethyl-4-chloropyrrolidine derivatives
HU385091D HUT61524A (en) 1989-05-11 1990-05-10 Process for producing 1,2,4-substituted pyrrolidine derivatives

Country Status (1)

Country Link
HU (4) HUT61525A (en)

Also Published As

Publication number Publication date
HUT61523A (en) 1993-01-28
HUT61524A (en) 1993-01-28
HU913852D0 (en) 1992-02-28
HU913853D0 (en) 1992-02-28
HU913850D0 (en) 1992-02-28
HUT61525A (en) 1993-01-28

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Legal Events

Date Code Title Description
DFC4 Cancellation of temporary prot. due to refusal