HUT61020A - Process for producing heterocyclic compounds - Google Patents

Process for producing heterocyclic compounds

Info

Publication number
HUT61020A
HUT61020A HU921270A HU127092A HUT61020A HU T61020 A HUT61020 A HU T61020A HU 921270 A HU921270 A HU 921270A HU 127092 A HU127092 A HU 127092A HU T61020 A HUT61020 A HU T61020A
Authority
HU
Hungary
Prior art keywords
alkyl
lower alkyl
cyclo
opt
halo
Prior art date
Application number
HU921270A
Other languages
Hungarian (hu)
Other versions
HU217427B (en
Inventor
Terence James Ward
Janet Christine White
Original Assignee
Wyeth John & Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth John & Brother Ltd filed Critical Wyeth John & Brother Ltd
Publication of HUT61020A publication Critical patent/HUT61020A/en
Publication of HU217427B publication Critical patent/HU217427B/en

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

4-oxo-quinoline and chromone derivs of formula (I) and their acid addn salts are new. R1 = H or at least one of lower alkyl, 0H, lower alkoxy, halo, methylenedioxy, halo-lower alkyl, N02, NH2, lower alkylamino or di-lower alkylamino. X = -0- of -NR2-. R2 = lower alkyl, lower alkenyl, lower alkynyl, cyclo(lover)alkyl, cyclo(lower)alkyl-lower alkyl, aryl, aryl(lower)alkyl, -(CH2)r-W-R8 or -Z-, which is connected to the 8-position of the aromatic ring to form a 5-7 membered heterocycle, in which the ring members represented by Z are -CH2-gps (opt substituted by at least one alkyl) and opt a hetero gp selected from 0 S, S02 or NR5. r = 1-4. W = 0, S, or NR5. R5 = H or lower alkyl. R8 = H, lower alkyl or cyclo(lower)alkyl. Y = 0 or NR3. R3 = H or lower alkyl. B = a standard azabicyclic ring of formula (II)-(V) or their N-oxides. m = 2, 3 or 4. R4 = H or lower alkyl. p = 1, 2 or 3. q = 0, 1 or 2. 15 cpds are specifically claimed, including (endo)-N-(8-methyl -8-azabicyclo(3.2.1)octan-3-yl 1,4-dihydro-1-methyl -4-oxoquinoline-3-carboxamide. Unit dose contains 0.5-750 mg of (I).
HU9201270A 1989-10-14 1990-10-10 Heterocyclic compounds and pharmaceutical compositions containing them as active components and process for producing HU217427B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898923209A GB8923209D0 (en) 1989-10-14 1989-10-14 Heterocyclic compounds
ZA912466A ZA912466B (en) 1989-10-14 1991-04-03 Heterocyclic compounds
CN91102395A CN1040756C (en) 1989-10-14 1991-04-09 heterocyclic compounds

Publications (2)

Publication Number Publication Date
HUT61020A true HUT61020A (en) 1992-11-30
HU217427B HU217427B (en) 2000-01-28

Family

ID=36778144

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9201270A HU217427B (en) 1989-10-14 1990-10-10 Heterocyclic compounds and pharmaceutical compositions containing them as active components and process for producing

Country Status (4)

Country Link
CN (1) CN1040756C (en)
GB (1) GB8923209D0 (en)
HU (1) HU217427B (en)
ZA (1) ZA912466B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR045141A1 (en) * 2003-07-31 2005-10-19 Neurosearch As TARTRATE SALTS OF 2- METOXIMETIL-3- (3,4-DICLOROFENIL) -8-AZABICICLO (3,2,1) OCTANO. PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME.
TW200800980A (en) * 2006-02-17 2008-01-01 Neurosearch As Novel compounds
CA3142748A1 (en) * 2019-06-12 2020-12-17 Praxis Biotech LLC Modulators of integrated stress response pathway

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135545A1 (en) * 1983-02-19 1985-04-03 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
DE3687080T2 (en) * 1985-04-27 1993-03-25 Beecham Group Plc AZABICYCLONONYL INDAZOL CARBOXAMIDE WITH 5-HT ANTAGONISTIC EFFECT.

Also Published As

Publication number Publication date
CN1065661A (en) 1992-10-28
GB8923209D0 (en) 1989-11-29
HU217427B (en) 2000-01-28
CN1040756C (en) 1998-11-18
ZA912466B (en) 1992-12-30

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee