HUT49611A - Process for producing oxetanocin deriatives and pharmaceutical composition comprising such compounds - Google Patents

Process for producing oxetanocin deriatives and pharmaceutical composition comprising such compounds

Info

Publication number
HUT49611A
HUT49611A HU891414A HU141489A HUT49611A HU T49611 A HUT49611 A HU T49611A HU 891414 A HU891414 A HU 891414A HU 141489 A HU141489 A HU 141489A HU T49611 A HUT49611 A HU T49611A
Authority
HU
Hungary
Prior art keywords
ch2oh
oxetanocin
base
ch2oco
halo
Prior art date
Application number
HU891414A
Other languages
Hungarian (hu)
Other versions
HU203552B (en
Inventor
Seiichi Saito
Shigeru Hasegawa
Katsutoshi Takahashi
Nobuyoshi Shimada
Jun-Ichi Seki
Hiroo Hoshino
Yukihiro Nishiyama
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63233651A external-priority patent/JP2620775B2/en
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of HUT49611A publication Critical patent/HUT49611A/en
Publication of HU203552B publication Critical patent/HU203552B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oxetanocin-related cpd. of formula (I) and their salts are new. R1 = CH2OH or CH2OCO (alkyl); Y = C=CH2, C=O or -C(R2)(R3)-; provided that R2 = H, OH or CH2OH and R3 = H, OH, halo, CH2OH, lower alkyl opt. substd. by halo, CH2-N3, N3, COOH, NH2, CH2OSO3H or CH2OCO (lower alkyl; B = a residue of purine base; provided that R1 and R3 are not both CH2OH. B = a residue of adenine base, guanine base, hypoxanthine base or 2-aminoadenine base. Also claimed is a pharmaceutical compsn. comprising an oxetanocin-related cpd. of formula (I) where R1 = R1a=CH2OH, CH2OCO (alkyl) or CH3; Y = as above; provided that R2 = H, OH, or CH2OH and R3 = R3a H, OH, halo, CH2OH, lower alkyl opt. substd. by halo, CH2N3, CH2f, N3, COOH, NH2, CH2OSO3H or CH2OCO (lower alkyl).
HU891414A 1988-03-23 1989-03-23 Process for producing oxetanocin derivatives and pharmaceutical composition containing them HU203552B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6725388 1988-03-23
JP63233651A JP2620775B2 (en) 1988-09-20 1988-09-20 Shape memory alloy device and pump

Publications (2)

Publication Number Publication Date
HUT49611A true HUT49611A (en) 1989-10-30
HU203552B HU203552B (en) 1991-08-28

Family

ID=26408431

Family Applications (1)

Application Number Title Priority Date Filing Date
HU891414A HU203552B (en) 1988-03-23 1989-03-23 Process for producing oxetanocin derivatives and pharmaceutical composition containing them

Country Status (1)

Country Link
HU (1) HU203552B (en)

Also Published As

Publication number Publication date
HU203552B (en) 1991-08-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee