HUT46032A - Process for producing semisynthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines - Google Patents

Process for producing semisynthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines

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Publication number
HUT46032A
HUT46032A HU132687A HU132687A HUT46032A HU T46032 A HUT46032 A HU T46032A HU 132687 A HU132687 A HU 132687A HU 132687 A HU132687 A HU 132687A HU T46032 A HUT46032 A HU T46032A
Authority
HU
Hungary
Prior art keywords
formula
substd
substituted
under
vincosides
Prior art date
Application number
HU132687A
Other languages
Hungarian (hu)
Other versions
HU200467B (en
Inventor
Akos Kocsis
Andrasne Patthy
Zoltan Pal
Laszlo Szabo
Jozsefne Varga
Peter Tetenyi
Original Assignee
Gyogynoeveny Kutato Intezet Kv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogynoeveny Kutato Intezet Kv filed Critical Gyogynoeveny Kutato Intezet Kv
Priority to HU132687A priority Critical patent/HU200467B/en
Publication of HUT46032A publication Critical patent/HUT46032A/en
Publication of HU200467B publication Critical patent/HU200467B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Semi-synthetic gluco-alkaloids of indole structure (I) and in partic Nb substd. special classes of these i.e. vincosides and strychtosidines are prepd. from substd. tryptamines of formula (II) and secologamine derivs of formula (III). In formula (I) R=H or acyl; R3-CO where R3 is an alkyl gp. (1-4C); R1=alkyl, alkenyl, aralkyl (1-5C), opt. the benzene ring is substd. by a halogen atom, nitro- alkoxy- or alkylamino-gp. R1 may be acyl gp. of formula R4-CO, where R4 is an alkyl-, aralkyl-, alkoxy or aralkyoxy- gp. (of 1-4C); 'O' in the tryptamine formula (II) is or an alkyl-aralkyl gp (1-5C); opt. the benzene ring is substd by a halogen atom, nitro-, alkoxy-, or arylamino- gps. R2 as in (I) In formula (III) of secologamine derivs., R=H or an acyl gp. of formula R3-CO where R3 as in (I). (a) In the prepn of Nb substd vincosides fo formula (1a) being a specific variant of (1), 'O' in cpd. (II) and R in cpd (III) are other than hydrogen. Prepn of cpd. (1a) is carried out in a nonpolar aprotic solvent, pref. benzene. The extracted prod. is opt. de-acylate. (b) Strychtosidines of formula (IV) are obtd. during the prepn of Nb substd strychtosidines of general formula (1b) a specific subgroup of cpds. (I). Cpds (IV) react with cpds R4-X (V) in the presence of a base of a greater conc. than a two-molar excess. Opt the end prod. is acylated.
HU132687A 1987-03-26 1987-03-26 Process for producing half-synthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines HU200467B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU132687A HU200467B (en) 1987-03-26 1987-03-26 Process for producing half-synthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU132687A HU200467B (en) 1987-03-26 1987-03-26 Process for producing half-synthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines

Publications (2)

Publication Number Publication Date
HUT46032A true HUT46032A (en) 1988-09-28
HU200467B HU200467B (en) 1990-06-28

Family

ID=10953937

Family Applications (1)

Application Number Title Priority Date Filing Date
HU132687A HU200467B (en) 1987-03-26 1987-03-26 Process for producing half-synthetic glycolalkaloids with indole skeleton, particularly new n under b-substituted vincosides and n under b-substituted strictosidines

Country Status (1)

Country Link
HU (1) HU200467B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046155A1 (en) * 2006-10-20 2008-04-24 Dia-B Tech Limited Methods for regulating glucose homeostasis and agents therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008046155A1 (en) * 2006-10-20 2008-04-24 Dia-B Tech Limited Methods for regulating glucose homeostasis and agents therefor

Also Published As

Publication number Publication date
HU200467B (en) 1990-06-28

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMA4 Cancellation of final prot. due to abandonment