HUT44032A - Process for production of new derivatives of pirimido /5,4-bis/1,4/ oxasen - Google Patents

Process for production of new derivatives of pirimido /5,4-bis/1,4/ oxasen

Info

Publication number
HUT44032A
HUT44032A HU855042A HU504285A HUT44032A HU T44032 A HUT44032 A HU T44032A HU 855042 A HU855042 A HU 855042A HU 504285 A HU504285 A HU 504285A HU T44032 A HUT44032 A HU T44032A
Authority
HU
Hungary
Prior art keywords
group
stands
hydrogen
alkyl
alkyl group
Prior art date
Application number
HU855042A
Other languages
English (en)
Other versions
HU195822B (en
Inventor
Endre Kasztreiner
Nandor Makk
Aniko Tegdes
Gyoergy Cseh
Andras Varro
Laszlo Szam
Kuerthy Maria Kuharne
Eszter Diesler
Peter Matyus
Laszlo Jaszlits
Janos Wellmann
Judit Kincsessy
Gyoergy Rabloczky
Laszlo Sebestyen
Gyuerki Sarolta Vegvarine
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Priority to HU855042A priority Critical patent/HU195822B/hu
Priority to NZ218795A priority patent/NZ218795A/xx
Priority to DK630186A priority patent/DK630186A/da
Priority to EP86118122A priority patent/EP0228094B1/de
Priority to FI865344A priority patent/FI82469C/fi
Priority to AU67043/86A priority patent/AU586380B2/en
Priority to ES8603622A priority patent/ES2003643A6/es
Priority to GR862962A priority patent/GR862962B/el
Priority to IL81117A priority patent/IL81117A/xx
Priority to CA000526548A priority patent/CA1287052C/en
Priority to DE8686118122T priority patent/DE3680893D1/de
Priority to CS8610262A priority patent/CS268822B2/cs
Priority to NO865347A priority patent/NO170935C/no
Priority to SU864028913A priority patent/SU1567122A3/ru
Priority to US06/947,700 priority patent/US4748175A/en
Priority to CN86108914A priority patent/CN1021734C/zh
Priority to YU227986A priority patent/YU46039B/sh
Priority to AT86118122T priority patent/ATE66232T1/de
Priority to DD86298832A priority patent/DD256701A5/de
Priority to JP62000083A priority patent/JPS62228082A/ja
Publication of HUT44032A publication Critical patent/HUT44032A/hu
Priority to CS103188A priority patent/CS272784B2/cs
Priority to SU884355907A priority patent/SU1567123A3/ru
Publication of HU195822B publication Critical patent/HU195822B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
HU855042A 1985-12-30 1985-12-30 Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives HU195822B (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
HU855042A HU195822B (en) 1985-12-30 1985-12-30 Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives
NZ218795A NZ218795A (hu) 1985-12-30 1986-12-23
DK630186A DK630186A (da) 1985-12-30 1986-12-29 Pyrimido(5,4-b)(1,4)oxazinderivater, tautomer, tautomerblandinger og syreadditionssalte deraf, deres fremstilling og anvendelse som laegemidler
CS8610262A CS268822B2 (en) 1985-12-30 1986-12-30 Method of pyrimido /5,4-/(1,4/-oxazine derivatives preparation
US06/947,700 US4748175A (en) 1985-12-30 1986-12-30 Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions containing them
AU67043/86A AU586380B2 (en) 1985-12-30 1986-12-30 Pyrimido ``5,4-b````1,4`` oxazine derivatives and pharmaceutical compositions containing them
ES8603622A ES2003643A6 (es) 1985-12-30 1986-12-30 Procedimiento de preparacion de los nuevos derivados pirimido (5,4-b) (1,4) oxazinos, asi como sus tautomeros y mezclas tautomeras y sales de adicion acidas de estos compuestos
GR862962A GR862962B (en) 1985-12-30 1986-12-30 Pyrimido (5,4-b) (1,4) oxazine derivatives preparation process
IL81117A IL81117A (en) 1985-12-30 1986-12-30 2-alkyl-6h-pyrimido-(5,4-b)(1,4)oxazin-7(8h)-ones,their preparation and pharmaceutical compositions containing them
CA000526548A CA1287052C (en) 1985-12-30 1986-12-30 Pyrimido[5,4-b][1,4]oxazine derivatives, pharmaceutical compositions containing them and process for preparing same
DE8686118122T DE3680893D1 (de) 1985-12-30 1986-12-30 Pyrimido(5,4-b)(1,4)oxazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie zwischenprodukte darstellende pyrimido(5,4-b)(1,4)oxazinderivate.
EP86118122A EP0228094B1 (de) 1985-12-30 1986-12-30 Pyrimido[5,4-b][1,4]oxazinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel sowie Zwischenprodukte darstellende Pyrimido[5,4-b][1,4]oxazinderivate
NO865347A NO170935C (no) 1985-12-30 1986-12-30 Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimido(5,4-b)(1,4)oxazinderivater
SU864028913A SU1567122A3 (ru) 1985-12-30 1986-12-30 Способ получени производных пиримидо (5-4 @ )-(1,4)оксазина или их аддитивных солей с кислотами
FI865344A FI82469C (fi) 1985-12-30 1986-12-30 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 2-metyl-4-substituerad amino-6,7-dihydro-8h -pyrimido/5,4-b//1,4/-oxazin-7-oner.
CN86108914A CN1021734C (zh) 1985-12-30 1986-12-30 制备嘧啶并[5，4-b][1，4]嗪衍生物的方法
YU227986A YU46039B (sh) 1985-12-30 1986-12-30 Postupak za dobivanje novih pirimido/5,4-b/1,4/oksazinskih derivata
AT86118122T ATE66232T1 (de) 1985-12-30 1986-12-30 Pyrimido(5,4-b>(1,4>oxazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie zwischenprodukte darstellende pyrimido(5,4-b>(1,4>oxazinderivate.
DD86298832A DD256701A5 (de) 1985-12-30 1986-12-30 Verfahren zur herstellung neuer pyrimido (5,4-b) (1,4)-oxozin-derivate
JP62000083A JPS62228082A (ja) 1985-12-30 1987-01-05 ピリミド（５，４−ｂ）（１，４）オキサジン誘導体およびこれを含む薬剤組成物ならびにその製造方法
CS103188A CS272784B2 (en) 1985-12-30 1988-02-18 Method of pyrimido (5,4-8) (1,4) oxazin derivatives preparation
SU884355907A SU1567123A3 (ru) 1985-12-30 1988-06-14 Способ получени производных пиримидо[5,4- @ ] [1,4]оксазина или их кислотно-аддитивных солей

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU855042A HU195822B (en) 1985-12-30 1985-12-30 Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives

Publications (2)

Publication Number Publication Date
HUT44032A true HUT44032A (en) 1988-01-28
HU195822B HU195822B (en) 1988-07-28

Family

ID=10969567

Family Applications (1)

Application Number Title Priority Date Filing Date
HU855042A HU195822B (en) 1985-12-30 1985-12-30 Process for producing new pyrimido/5,4-b//1,h/oxazine derivatives

Country Status (20)

Country Link
US (1) US4748175A (hu)
EP (1) EP0228094B1 (hu)
JP (1) JPS62228082A (hu)
CN (1) CN1021734C (hu)
AT (1) ATE66232T1 (hu)
AU (1) AU586380B2 (hu)
CA (1) CA1287052C (hu)
CS (1) CS268822B2 (hu)
DD (1) DD256701A5 (hu)
DE (1) DE3680893D1 (hu)
DK (1) DK630186A (hu)
ES (1) ES2003643A6 (hu)
FI (1) FI82469C (hu)
GR (1) GR862962B (hu)
HU (1) HU195822B (hu)
IL (1) IL81117A (hu)
NO (1) NO170935C (hu)
NZ (1) NZ218795A (hu)
SU (2) SU1567122A3 (hu)
YU (1) YU46039B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64917B1 (en) * 1988-02-05 1995-09-20 Riker Laboratories Inc Triazolo[1,5-c]pyrimido[1,4]azines as bronchodilators
GB2359551A (en) * 2000-02-23 2001-08-29 Astrazeneca Uk Ltd Pharmaceutically active pyrimidine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215216A (en) * 1979-04-18 1980-07-29 American Home Products Corporation 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives

Also Published As

Publication number Publication date
DE3680893D1 (de) 1991-09-19
YU227986A (en) 1988-02-29
EP0228094B1 (de) 1991-08-14
CA1287052C (en) 1991-07-30
FI865344A (fi) 1987-07-01
IL81117A0 (en) 1987-03-31
GR862962B (en) 1987-05-05
CN1021734C (zh) 1993-08-04
DK630186A (da) 1987-07-01
YU46039B (sh) 1992-12-21
EP0228094A2 (de) 1987-07-08
HU195822B (en) 1988-07-28
DD256701A5 (de) 1988-05-18
IL81117A (en) 1990-07-12
EP0228094A3 (en) 1988-10-12
DK630186D0 (da) 1986-12-29
FI865344A0 (fi) 1986-12-30
ATE66232T1 (de) 1991-08-15
FI82469C (fi) 1991-03-11
SU1567122A3 (ru) 1990-05-23
AU6704386A (en) 1987-07-02
SU1567123A3 (ru) 1990-05-23
NZ218795A (hu) 1989-02-24
NO170935B (no) 1992-09-21
ES2003643A6 (es) 1988-11-01
JPS62228082A (ja) 1987-10-06
FI82469B (fi) 1990-11-30
CS268822B2 (en) 1990-04-11
CN86108914A (zh) 1987-09-30
NO865347L (no) 1987-07-01
CS1026286A2 (en) 1989-08-14
NO170935C (no) 1992-12-30
US4748175A (en) 1988-05-31
AU586380B2 (en) 1989-07-06

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee