HUP9904439A2 - {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them - Google Patents

{2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them

Info

Publication number
HUP9904439A2
HUP9904439A2 HU9904439A HUP9904439A HUP9904439A2 HU P9904439 A2 HUP9904439 A2 HU P9904439A2 HU 9904439 A HU9904439 A HU 9904439A HU P9904439 A HUP9904439 A HU P9904439A HU P9904439 A2 HUP9904439 A2 HU P9904439A2
Authority
HU
Hungary
Prior art keywords
phenyl
ethoxy
chloro
benzyl
alpha
Prior art date
Application number
HU9904439A
Other languages
Hungarian (hu)
Inventor
Péter Trinka
József Reiter
Ferenc Bartha
Gyula Simig
György Clementis
Kálmán Nagy
Péter Tömpe
Donáth Györgyi Vereczkeyné
Norbert Németh
Pál Vágó
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9904439A priority Critical patent/HU226639B1/en
Publication of HU9904439D0 publication Critical patent/HU9904439D0/en
Priority to US10/148,704 priority patent/US6908999B2/en
Priority to PL354677A priority patent/PL200046B1/en
Priority to JP2001541895A priority patent/JP4763954B2/en
Priority to EP00981508A priority patent/EP1233954B1/en
Priority to AU18742/01A priority patent/AU1874201A/en
Priority to CZ2002-1712A priority patent/CZ304892B6/en
Priority to AT00981508T priority patent/ATE280165T1/en
Priority to DE60015177T priority patent/DE60015177T2/en
Priority to PCT/HU2000/000123 priority patent/WO2001040211A1/en
Priority to SK752-2002A priority patent/SK285641B6/en
Priority to UA2002065341A priority patent/UA72949C2/en
Priority to RU2002118101/04A priority patent/RU2248974C2/en
Priority to SI200030569T priority patent/SI1233954T1/en
Publication of HUP9904439A2 publication Critical patent/HUP9904439A2/en
Publication of HUP9904439A3 publication Critical patent/HUP9904439A3/en
Priority to HR20020470A priority patent/HRP20020470B1/en
Priority to BG106760A priority patent/BG65455B1/en
Publication of HU226639B1 publication Critical patent/HU226639B1/en

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Abstract

Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide of formula (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. R1 and R2 = 1-4C alkyl optionally substituted by a phenyl, 2-4C alkenyl or cyclohexyl; R1+R2+N = morpholine. Independent claims are also included for: (1) (I) and its acid addition salts; and (2) preparation of (I).
HU9904439A 1999-11-30 1999-11-30 {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them HU226639B1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
HU9904439A HU226639B1 (en) 1999-11-30 1999-11-30 {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them
SI200030569T SI1233954T1 (en) 1999-11-30 2000-11-29 A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl)ethoxy acetic acid and novel intermediates therefor
DE60015177T DE60015177T2 (en) 1999-11-30 2000-11-29 PROCESS FOR PREPARING 2- [4- (ALPHA-PHENYL-P-CHLOROBENZYL) PIPERAZINE-1-YL] ETHOXY ACETIC ACID AND INTERMEDIATES THEREFOR
SK752-2002A SK285641B6 (en) 1999-11-30 2000-11-29 A process for the preparation of {2-[4-(alpha-phenyl-p- chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid and novel intermediates therefor
JP2001541895A JP4763954B2 (en) 1999-11-30 2000-11-29 Process for the production of {2- [4- (α-phenyl-p-chlorobenzyl) piperazin-1-yl] ethoxy} acetic acid and novel intermediates therefor
EP00981508A EP1233954B1 (en) 1999-11-30 2000-11-29 A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy acetic acid and novel intermediates therefor
AU18742/01A AU1874201A (en) 1999-11-30 2000-11-29 A process for the preparation of (2-(4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl)ethoxy) acetic acid and novel intermediates therefor
CZ2002-1712A CZ304892B6 (en) 1999-11-30 2000-11-29 Process for preparing {2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid and novel intermediates
AT00981508T ATE280165T1 (en) 1999-11-30 2000-11-29 METHOD FOR PRODUCING 2-(4-(ALPHA-PHENYL-P-CHLOROBENZYL)PIPERAZINE-1-YL)ETHOXYACETIC ACID AND INTERMEDIATE PRODUCTS THEREFOR
US10/148,704 US6908999B2 (en) 1999-11-30 2000-11-29 Process for the preparation of {2-[4-α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor
PCT/HU2000/000123 WO2001040211A1 (en) 1999-11-30 2000-11-29 A PROCESS FOR THE PREPARATION OF {2-[4-(α-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR
PL354677A PL200046B1 (en) 1999-11-30 2000-11-29 A PROCESS FOR THE PREPARATION OF {2−[4−(α−PHENYL−p−CHLOROBENZYL)PIPERAZIN−1−YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR
UA2002065341A UA72949C2 (en) 1999-11-30 2000-11-29 A PROCESS FOR THE PREPARATION OF {2-[4-(a-PHENYL-P-CHLOROBENZENE-1-YL]-ETHOXY}ACETIC ACID AND INTERMEDIARY COMPOUNDS
RU2002118101/04A RU2248974C2 (en) 1999-11-30 2000-11-29 Method for preparing {2-[4-(alpha-phenyl-para-chlorobenzyl)piperazine-1-yl]ethoxy}-acetic acid and new intermediate compounds
HR20020470A HRP20020470B1 (en) 1999-11-30 2002-05-28 A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR
BG106760A BG65455B1 (en) 1999-11-30 2002-05-30 A PROCESS FOR THE PREPARATION OF {2-[4-(ALPHA-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREOF

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9904439A HU226639B1 (en) 1999-11-30 1999-11-30 {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them

Publications (4)

Publication Number Publication Date
HU9904439D0 HU9904439D0 (en) 2000-01-28
HUP9904439A2 true HUP9904439A2 (en) 2001-12-28
HUP9904439A3 HUP9904439A3 (en) 2002-01-28
HU226639B1 HU226639B1 (en) 2009-05-28

Family

ID=90000076

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904439A HU226639B1 (en) 1999-11-30 1999-11-30 {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them

Country Status (1)

Country Link
HU (1) HU226639B1 (en)

Also Published As

Publication number Publication date
HU9904439D0 (en) 2000-01-28
HU226639B1 (en) 2009-05-28
HUP9904439A3 (en) 2002-01-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees