HUP9904439A2 - {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them - Google Patents
{2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing themInfo
- Publication number
- HUP9904439A2 HUP9904439A2 HU9904439A HUP9904439A HUP9904439A2 HU P9904439 A2 HUP9904439 A2 HU P9904439A2 HU 9904439 A HU9904439 A HU 9904439A HU P9904439 A HUP9904439 A HU P9904439A HU P9904439 A2 HUP9904439 A2 HU P9904439A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- ethoxy
- chloro
- benzyl
- alpha
- Prior art date
Links
- LVJDQBJDVOYDLA-UHFFFAOYSA-N 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetamide Chemical class C1CN(CCOCC(=O)N)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 LVJDQBJDVOYDLA-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 5
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000002184 metal Chemical class 0.000 abstract 2
- 239000003444 phase transfer catalyst Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. Preparation of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetic acid, its acid addition salts and metal salts involves hydrolysis of (2-(4-(alpha-phenyl-para-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide of formula (I) or its acid addition salts in alkaline or acidic medium and optionally in the presence of a phase transfer catalyst. R1 and R2 = 1-4C alkyl optionally substituted by a phenyl, 2-4C alkenyl or cyclohexyl; R1+R2+N = morpholine. Independent claims are also included for: (1) (I) and its acid addition salts; and (2) preparation of (I).
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9904439A HU226639B1 (en) | 1999-11-30 | 1999-11-30 | {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them |
SI200030569T SI1233954T1 (en) | 1999-11-30 | 2000-11-29 | A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl)ethoxy acetic acid and novel intermediates therefor |
DE60015177T DE60015177T2 (en) | 1999-11-30 | 2000-11-29 | PROCESS FOR PREPARING 2- [4- (ALPHA-PHENYL-P-CHLOROBENZYL) PIPERAZINE-1-YL] ETHOXY ACETIC ACID AND INTERMEDIATES THEREFOR |
SK752-2002A SK285641B6 (en) | 1999-11-30 | 2000-11-29 | A process for the preparation of {2-[4-(alpha-phenyl-p- chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid and novel intermediates therefor |
JP2001541895A JP4763954B2 (en) | 1999-11-30 | 2000-11-29 | Process for the production of {2- [4- (α-phenyl-p-chlorobenzyl) piperazin-1-yl] ethoxy} acetic acid and novel intermediates therefor |
EP00981508A EP1233954B1 (en) | 1999-11-30 | 2000-11-29 | A process for the preparation of 2- 4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy acetic acid and novel intermediates therefor |
AU18742/01A AU1874201A (en) | 1999-11-30 | 2000-11-29 | A process for the preparation of (2-(4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl)ethoxy) acetic acid and novel intermediates therefor |
CZ2002-1712A CZ304892B6 (en) | 1999-11-30 | 2000-11-29 | Process for preparing {2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy}acetic acid and novel intermediates |
AT00981508T ATE280165T1 (en) | 1999-11-30 | 2000-11-29 | METHOD FOR PRODUCING 2-(4-(ALPHA-PHENYL-P-CHLOROBENZYL)PIPERAZINE-1-YL)ETHOXYACETIC ACID AND INTERMEDIATE PRODUCTS THEREFOR |
US10/148,704 US6908999B2 (en) | 1999-11-30 | 2000-11-29 | Process for the preparation of {2-[4-α-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxy} acetic acid and novel intermediates therefor |
PCT/HU2000/000123 WO2001040211A1 (en) | 1999-11-30 | 2000-11-29 | A PROCESS FOR THE PREPARATION OF {2-[4-(α-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
PL354677A PL200046B1 (en) | 1999-11-30 | 2000-11-29 | A PROCESS FOR THE PREPARATION OF {2−[4−(α−PHENYL−p−CHLOROBENZYL)PIPERAZIN−1−YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
UA2002065341A UA72949C2 (en) | 1999-11-30 | 2000-11-29 | A PROCESS FOR THE PREPARATION OF {2-[4-(a-PHENYL-P-CHLOROBENZENE-1-YL]-ETHOXY}ACETIC ACID AND INTERMEDIARY COMPOUNDS |
RU2002118101/04A RU2248974C2 (en) | 1999-11-30 | 2000-11-29 | Method for preparing {2-[4-(alpha-phenyl-para-chlorobenzyl)piperazine-1-yl]ethoxy}-acetic acid and new intermediate compounds |
HR20020470A HRP20020470B1 (en) | 1999-11-30 | 2002-05-28 | A PROCESS FOR THE PREPARATION OF {2-[4-(alpha-PHENYL-p-CHLORBENZYL)-PIPERAZIN-1-YL]ETHOXY} ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR |
BG106760A BG65455B1 (en) | 1999-11-30 | 2002-05-30 | A PROCESS FOR THE PREPARATION OF {2-[4-(ALPHA-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREOF |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9904439A HU226639B1 (en) | 1999-11-30 | 1999-11-30 | {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them |
Publications (4)
Publication Number | Publication Date |
---|---|
HU9904439D0 HU9904439D0 (en) | 2000-01-28 |
HUP9904439A2 true HUP9904439A2 (en) | 2001-12-28 |
HUP9904439A3 HUP9904439A3 (en) | 2002-01-28 |
HU226639B1 HU226639B1 (en) | 2009-05-28 |
Family
ID=90000076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9904439A HU226639B1 (en) | 1999-11-30 | 1999-11-30 | {2-[4-(alpha-phenyl-p-chloro-benzyl)-piperazine-1-yl]-ethoxy}-acetic acid-amides and process for producing them |
Country Status (1)
Country | Link |
---|---|
HU (1) | HU226639B1 (en) |
-
1999
- 1999-11-30 HU HU9904439A patent/HU226639B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU9904439D0 (en) | 2000-01-28 |
HU226639B1 (en) | 2009-05-28 |
HUP9904439A3 (en) | 2002-01-28 |
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Legal Events
Date | Code | Title | Description |
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HC9A | Change of name, address |
Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |