HUP9904289A2 - Pyridines substituted by heterocyclic groups, method for their production and pharmaceutical compositions containing the same - Google Patents
Pyridines substituted by heterocyclic groups, method for their production and pharmaceutical compositions containing the sameInfo
- Publication number
- HUP9904289A2 HUP9904289A2 HU9904289A HUP9904289A HUP9904289A2 HU P9904289 A2 HUP9904289 A2 HU P9904289A2 HU 9904289 A HU9904289 A HU 9904289A HU P9904289 A HUP9904289 A HU P9904289A HU P9904289 A2 HUP9904289 A2 HU P9904289A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- oxygen atom
- production
- compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical group NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 238000006000 Knoevenagel condensation reaction Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- CKSZCFRCBFCTJW-UHFFFAOYSA-N 5-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one Chemical compound CC1=NC=C(CO)C(C=C2C(NC(=S)S2)=O)=C1O CKSZCFRCBFCTJW-UHFFFAOYSA-N 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 229930003270 Vitamin B Natural products 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000006911 enzymatic reaction Methods 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 230000001613 neoplastic effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
- 235000019156 vitamin B Nutrition 0.000 abstract 1
- 239000011720 vitamin B Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
A találmány (8) általános képletű új Knoevenagel-kondenzációstermékekre, azok sóira, hidrátjaira és sztereoizomerjeire, azelőállításukra szolgáló eljárásra, továbbá - különösen gyógyszerészetiés analitikai célú - alkalmazásukra vonatkozik. A találmány tárgyátképezik továbbá a Knoevenagel-kondenzáció termékeinek biomolekulákkalalkotott konjugátumai. A képletben X1, X2 és X3 jelentése egymástól függetlenül oxigénatom, kénatom vagyNR5 csoport; Y jelentése oxigénatom vagy kénatom; Z jelentése CR5 általános képletű csoport vagy nitrogénatom; R1, R2, R3, R4 és R5 egymástól függetlenül tetszés szerintmegválasztott különböző szubsztituens, azzal a megkötéssel, hogy R1-R4szubsztituensek legalább egyike foszfát-, karboxilát- vagy egyébnegatív töltésű csoport; R6 jelentése adott esetben szubsztituált szénhidrogéncsoport vagyoxigénatom, és n értéke nulla vagy 1, azzal a megkötéssel, hogy evegyületek piridoxilidén-rodanintól eltérőek. A (8) általános képletűvegyületek gyógyhatásúak és elsősorban fertőző betegségek, főkéntvírusfertőzések, daganatos betegségek, a B-vitamin-anyagcserével, azimmunrendszer zavaraival, valamint az enzimes reakciók zavaraivalösszefüggő betegségek elleni hatással rendelkeznek. A találmánytárgyát képezik tehát a (8) általános képletű vegyületeket tartalmazógyógyszerkészítmények is. ÓThe invention relates to new Knoevenagel condensation products of the general formula (8), their salts, hydrates and stereoisomers, the process for their production, and their use - especially for pharmaceutical and analytical purposes. The invention also covers conjugates of the products of the Knoevenagel condensation with biomolecules. In the formula, X1, X2 and X3 are independently an oxygen atom, a sulfur atom or an NR5 group; Y is an oxygen atom or a sulfur atom; Z is a group of formula CR5 or a nitrogen atom; R 1 , R 2 , R 3 , R 4 and R 5 are different substituents independently chosen as desired, with the stipulation that at least one of the R 1 -R 4 substituents is a phosphate, carboxylate or other negatively charged group; R6 is an optionally substituted hydrocarbon group or an oxygen atom, and the value of n is zero or 1, with the proviso that these compounds are different from pyridoxylidene-rhodanine. The compounds of general formula (8) are medicinal and primarily have an effect against infectious diseases, mainly viral infections, neoplastic diseases, diseases related to vitamin B metabolism, disorders of the immune system, and disorders of enzymatic reactions. The subject of the invention is therefore also pharmaceutical preparations containing compounds of general formula (8). HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19645974A DE19645974C1 (en) | 1996-11-07 | 1996-11-07 | (Z) -5 - [[3-Hydroxy-2-methyl-5 - [(phosphonooxy) methyl] -4-pyridinyl] methylene] -2-thioxo-4-thiazolidinone, process for its preparation and use |
| PCT/EP1997/006184 WO1998020013A1 (en) | 1996-11-07 | 1997-11-07 | New knoevenagel condensation products, method for their production and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9904289A2 true HUP9904289A2 (en) | 2001-04-28 |
| HUP9904289A3 HUP9904289A3 (en) | 2001-08-28 |
Family
ID=7810958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9904289A HUP9904289A3 (en) | 1996-11-07 | 1997-11-07 | Pyridines substituted by heterocyclic groups, method for their production and pharmaceutical compositions containing the same |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0937089A1 (en) |
| JP (1) | JP2001503752A (en) |
| KR (1) | KR20000053141A (en) |
| CN (1) | CN1236369A (en) |
| AU (1) | AU728345B2 (en) |
| BR (1) | BR9712930A (en) |
| CA (1) | CA2270973A1 (en) |
| CZ (1) | CZ160999A3 (en) |
| DE (1) | DE19645974C1 (en) |
| HU (1) | HUP9904289A3 (en) |
| IL (1) | IL129826A0 (en) |
| NO (1) | NO992209L (en) |
| NZ (1) | NZ335977A (en) |
| PL (1) | PL333128A1 (en) |
| SK (1) | SK61799A3 (en) |
| TR (1) | TR199901733T2 (en) |
| WO (1) | WO1998020013A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9910207A (en) | 1998-05-04 | 2001-01-09 | Andreas Johannes Kesel | Monomeric, oligomeric and polymeric knoevenagel condensation products |
| AU743411B2 (en) * | 1998-08-21 | 2002-01-24 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
| CA2371653A1 (en) * | 1999-04-30 | 2000-11-09 | Walter Oberthur | Antioxidative vitamin b6 analogs |
| US6940497B2 (en) | 2001-10-16 | 2005-09-06 | Hewlett-Packard Development Company, L.P. | Portable electronic reading apparatus |
| US20030071780A1 (en) * | 2001-10-16 | 2003-04-17 | Vincent Kent D. | High resolution display |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103776D0 (en) * | 1991-12-19 | 1991-12-19 | Astra Ab | NEW COMPOUNDS |
| IT1266570B1 (en) * | 1993-07-30 | 1997-01-09 | Zambon Spa | DERIVATIVES OF PROPANAMIDE N-ETEROARYL SUBSTITUTES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES |
| FR2722790B1 (en) * | 1994-07-19 | 1996-10-04 | Roussel Uclaf | NOVEL CEPHALOSPORINS COMPRISING IN POSITION 7 A SUBSTITUTED RADICAL BENZYLOXYMINO, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS |
-
1996
- 1996-11-07 DE DE19645974A patent/DE19645974C1/en not_active Expired - Fee Related
-
1997
- 1997-11-07 NZ NZ335977A patent/NZ335977A/en unknown
- 1997-11-07 EP EP97951145A patent/EP0937089A1/en not_active Withdrawn
- 1997-11-07 CN CN97199496A patent/CN1236369A/en active Pending
- 1997-11-07 BR BRPI9712930-5A patent/BR9712930A/en not_active IP Right Cessation
- 1997-11-07 IL IL12982697A patent/IL129826A0/en unknown
- 1997-11-07 AU AU54798/98A patent/AU728345B2/en not_active Revoked
- 1997-11-07 PL PL97333128A patent/PL333128A1/en unknown
- 1997-11-07 TR TR1999/01733T patent/TR199901733T2/en unknown
- 1997-11-07 CA CA002270973A patent/CA2270973A1/en not_active Withdrawn
- 1997-11-07 KR KR1019990704073A patent/KR20000053141A/en not_active Application Discontinuation
- 1997-11-07 JP JP52107198A patent/JP2001503752A/en active Pending
- 1997-11-07 SK SK617-99A patent/SK61799A3/en unknown
- 1997-11-07 CZ CZ991609A patent/CZ160999A3/en unknown
- 1997-11-07 HU HU9904289A patent/HUP9904289A3/en unknown
- 1997-11-07 WO PCT/EP1997/006184 patent/WO1998020013A1/en not_active Application Discontinuation
-
1999
- 1999-05-06 NO NO992209A patent/NO992209L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL333128A1 (en) | 1999-11-22 |
| NO992209L (en) | 1999-07-01 |
| CZ160999A3 (en) | 1999-09-15 |
| CA2270973A1 (en) | 1998-05-14 |
| WO1998020013A1 (en) | 1998-05-14 |
| JP2001503752A (en) | 2001-03-21 |
| DE19645974C1 (en) | 1998-08-13 |
| BR9712930A (en) | 2006-04-18 |
| NO992209D0 (en) | 1999-05-06 |
| CN1236369A (en) | 1999-11-24 |
| KR20000053141A (en) | 2000-08-25 |
| SK61799A3 (en) | 2000-01-18 |
| NZ335977A (en) | 2000-12-22 |
| IL129826A0 (en) | 2000-02-29 |
| HUP9904289A3 (en) | 2001-08-28 |
| AU5479898A (en) | 1998-05-29 |
| EP0937089A1 (en) | 1999-08-25 |
| AU728345B2 (en) | 2001-01-04 |
| TR199901733T2 (en) | 1999-09-21 |
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