HUP9903110A2 - Hexahydro-pyrido[4,3-b]indole derivatives and their use as antipsychotic drugs - Google Patents
Hexahydro-pyrido[4,3-b]indole derivatives and their use as antipsychotic drugsInfo
- Publication number
- HUP9903110A2 HUP9903110A2 HU9903110A HUP9903110A HUP9903110A2 HU P9903110 A2 HUP9903110 A2 HU P9903110A2 HU 9903110 A HU9903110 A HU 9903110A HU P9903110 A HUP9903110 A HU P9903110A HU P9903110 A2 HUP9903110 A2 HU P9903110A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- aryl
- amino
- phenyl
- alkyloxy
- Prior art date
Links
- BPPMRCNUQCVVFJ-UHFFFAOYSA-N 2,3,4,4a,5,9b-hexahydro-1h-pyrido[4,3-b]indole Chemical class N1C2=CC=CC=C2C2C1CCNC2 BPPMRCNUQCVVFJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- -1 mercapto, amino Chemical group 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Hexahydro-pyrido(4,3-b)indole derivatives of formula (I), their N-oxides, salts and stereoisomers are new. Alk = 1-6C alkanediyl; R1 = H, 1-6C alkyl, aryl or aryl(1-6C alkyl); R2-R4 = H, halo, OH, NO2, CN, CF3, 1-6C alkyl, 1-6C alkyloxy, 1-6C alkylthio, mercapto, amino, mono- or di(1-6C alkyl)amino, carboxyl, 1-6C alkyloxycarbonyl or 1-6C alkylcarbonyl; R5 = H, 1-6C alkyl, phenyl or phenyl(1-6C alkyl); R6 = H, 1-6C alkyl, 1-6C alkyloxy, 1-6C alkylthio or NR8R9; R8, R9 = H, 1-6C alkyl, phenyl or phenyl(1-6C alkyl); R7 = H or 1-6C alkyl; or R6+R7 = a bivalent radical -R6-R7- which may be CH2CH2CH2 (a1), CH2CH2CH2CH2 (a2), CH=CHCH2 (a3), CH2CH=CH (a4), CH=CHCH=CH (a5); SCH2CH2 (a6), SCH2CH2CH2 (a7), SCH=CH (a8), NHCH2CH2 (a9), NHCH2CH2CH2 (a10), NHCH=CH (a11), NHCH=N (a12), SCH=N (a13) or CH=CH-O (a14); (a1)-(a5) are all optionally mono- or disubstituted by halo, 1-6C alkyl, aryl(1-6C alkyl), CF3, amino, OH, 1-6C alkyloxy or 1-10C alkylcarbonyloxy, or where possible two geminal H atoms are replaced by 1-6C alkylidene or aryl(1-6C alkylidene); and (a6)-(a14) are all optionally mono-, di- or trisubstituted by 1-6C alkyl or aryl; aryl = phenyl optionally substituted by up to three of halo, OH, NO2, CN, CF3, 1-6C alkyl, 1-6C alkyloxy, 1-6C alkylthio, mercapto, amino, mono- or di(1-6C alkyl)amino, carboxyl, 1-6C alkyloxycarbonyl and 1-6C alkylcarbonyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903110A HUP9903110A3 (en) | 1997-05-15 | 1997-05-15 | Hexahydro-pyrido[4,3-b]indole derivatives and their use as antipsychotic drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903110A HUP9903110A3 (en) | 1997-05-15 | 1997-05-15 | Hexahydro-pyrido[4,3-b]indole derivatives and their use as antipsychotic drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903110A2 true HUP9903110A2 (en) | 2000-01-28 |
| HUP9903110A3 HUP9903110A3 (en) | 2002-03-28 |
Family
ID=89999320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903110A HUP9903110A3 (en) | 1997-05-15 | 1997-05-15 | Hexahydro-pyrido[4,3-b]indole derivatives and their use as antipsychotic drugs |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9903110A3 (en) |
-
1997
- 1997-05-15 HU HU9903110A patent/HUP9903110A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903110A3 (en) | 2002-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |