HUP9902949A2 - Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor - Google Patents
Aryl substituted cyclic amines as selective ligands of dopamine d3 receptorInfo
- Publication number
- HUP9902949A2 HUP9902949A2 HU9902949A HUP9902949A HUP9902949A2 HU P9902949 A2 HUP9902949 A2 HU P9902949A2 HU 9902949 A HU9902949 A HU 9902949A HU P9902949 A HUP9902949 A HU P9902949A HU P9902949 A2 HUP9902949 A2 HU P9902949A2
- Authority
- HU
- Hungary
- Prior art keywords
- aryl
- alkyl
- cor4
- halo
- jso2r3
- Prior art date
Links
- 125000003118 aryl group Chemical group 0.000 title abstract 17
- 102000004073 Dopamine D3 Receptors Human genes 0.000 title 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 18
- 101100295741 Gallus gallus COR4 gene Proteins 0.000 abstract 5
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Aryl and heteroaryl fused cycloalkyl-amines of formulae (I), (II), and (III), and their salts, enantiomers, and racemates, are new. When n = 1, then X = JCONR4R5, JSO2R3, JSO2NR4R5, JNR4CONHR5, JNHSO2R3, JNHCOR3, or COR4; and Y = R4, GCONR4R5, GCN, GSO2NR4R5, OR6, GSO2R3, GNHSO2R3, halo or GNHCOR3; J = (CH2)m; G = (CH2)p; m, p = 0 or 1, but, when m = 0, then Y is not H or halo; when n = 0 and Y = OR9, then X = JCONR4R5, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3 or COR4; or when n = 0 or 1, then XY in adjacent positions together = CONR10CO, CONR4(CH2)xNR10CO, CH2NR10CO, CH2CH2NR10CO, CH2CONR10, NR3CONR3, NR3COO, N=C(R7)NR3, or CH2N(R8)CH2; x = 0 or 1; R1, R2 = H, 1-8C alkyl, or aryl 1-8C alkyl; R3 = 1-8C alkyl, aryl, or aryl(1-6C alkyl); R4, R5 = H, 1-8C alkyl, aryl, or aryl(1-6C alkyl); R6 = H, 1-8C alkyl, aryl(1-6C alkyl), CF3SO2-aryl, 1-8C alkylsulphonyl, arylsulphonyl, or aryl(1-6C alkylsulphonyl); R7 = H, CONR4R4, SO2NR4R4, or SO2R4; R8 = 1-8C alkyl, aryl 1-6C alkyl, aryl, CONR4R4, COR4, SO2NR4R4, or SO2R4, provided in each case that R4 is not H; R9 = 2-8C alkyl (optionally substituted by 1-3 halo), aryl, or aryl(1-6C alkyl); and R10 = H, 1-8C alkyl, aryl, aryl(1-6C alkyl), arylsulphonyl, or arylsulphonyl(1-6C alkyl); one of A-D = N, the others = CH; k = 1 or 2; X', Y' = (i) substituted at A, B, C or D and X' = JCONR4R5, JCN, OSO2R3, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3, or COR4; Y' = R4, GCONR4R5, GCN, GSO2NR4R5, OR61, OSO2R3, GSO2R3, GNHSO2R3, halo or GNHCOR3 (provided that when m = 0, then Y' is not H or halo); (ii) jointly in adjacent positions CONR4CO, CH2NR4CO, CH2CONR4 or CH2N(R4)CH2; R61 = H, MeSO2, CF3SO2, arylsulphonyl, 1-8C alkyl, aryl, or aryl 1-6C alkyl; one of E, F = N, the other = S; X" = JCONR4R5, JCN, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3 or COR4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902949A HUP9902949A3 (en) | 1997-05-12 | 1997-05-12 | Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902949A HUP9902949A3 (en) | 1997-05-12 | 1997-05-12 | Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9902949A2 true HUP9902949A2 (en) | 2000-02-28 |
| HUP9902949A3 HUP9902949A3 (en) | 2000-09-28 |
Family
ID=89999184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902949A HUP9902949A3 (en) | 1997-05-12 | 1997-05-12 | Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP9902949A3 (en) |
-
1997
- 1997-05-12 HU HU9902949A patent/HUP9902949A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9902949A3 (en) | 2000-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0552321T3 (en) | Process for making endorsements on diamonds | |
| PL295030A1 (en) | Method of obtaining substituted derivatives of 2-cyclohexan-1-yl amine | |
| ATE276770T1 (en) | DOPAMINE AND SEROTONIN TRANSPORT LIGANDS AND IMAGING AGENTS | |
| DE69331329T2 (en) | HETEROCYCLIC ETHER DERIVATIVES FOR STRENGTHENING THE COGNITIVE FUNCTIONS | |
| ES2113368T3 (en) | SEROTONIN ANTAGONISTS. | |
| DK0657428T3 (en) | Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates useful as opioid antagonists | |
| PT867436E (en) | N-ARYL-PIPERIDINE DERIVATIVES AND THEIR USE AS 5-HT1B RECEPTOR LIGANDS | |
| DK0828742T3 (en) | Diazepine indoles as phoshodiesterase 4 inhibitors | |
| AR017542A1 (en) | NAFTOPIRANO [INDOL] COMPOUNDS, PROCEDURE TO PREPARE THEM, A (CO) POLYMER, A PHOTOCROMATIC COMPOSITE, A PHOTOCROMATIC COMPOSITION, A POLYMER (CO) MATRIX, A SOLAR ARTICLE AND A GLASS, ALL BASED ON THE COMPOUNDS | |
| IL106387A (en) | Indole derivatives, their preparation and pharmaceutical compositions containing them | |
| DK0486386T3 (en) | New N-benzoylproline derivatives, processes for their preparation and pharmaceutical agents containing them | |
| DK0387618T3 (en) | New 1,7-canceled 1H-indole-2-carboxylic acid N- (1,4-benzodiazepin-3-yl) amides | |
| ES2152379T3 (en) | CONDENSED DIHYDROPIRIDINS AND ITS USE FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS. | |
| HUP9902949A2 (en) | Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor | |
| DK0658557T3 (en) | Eburnan derivatives, process for preparing such derivatives and pharmaceutical compositions containing them | |
| SE9700706D0 (en) | Process for the preparation of benzothiazoline compounds | |
| DK367783A (en) | PROCEDURE FOR THE PREPARATION OF GUANIDINE DERIVATIVES | |
| DK0816358T3 (en) | 4-Amino-2-ureidopyrimidine-5-carboxylic acid amides, process for their preparation, drugs containing such compounds and their use | |
| DK1073664T3 (en) | (alpha-aminophosphine) peptide derivatives and compositions containing them | |
| DE3569240D1 (en) | PHENYLALKYL AMINE BIOREGULATORS | |
| GR1001309B (en) | Process for the preparation of dichloroaniline compound | |
| DK231781A (en) | CUTTING MACHINE, SPECIFICALLY FOR CUTTING FRAME FRAME LAMPS | |
| DK145080A (en) | METHOD FOR PREPARING AMINO DERIVATIVES OF 2-HYDROXY-6,9-METHANO-11-AMINO-5,6,7,8,9,10-HEXAHYDROBENZOCYCLOOCTEN | |
| DK0521766T3 (en) | New method for synthesis of enantiomers of 3-aminochromane derivatives | |
| DK150305C (en) | ANALOGY PROCEDURE FOR PREPARING TETRAHYDROTHIOPYRANO (3,2-B) INDOL DERIVATIVES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |