HUP9902949A2 - Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor - Google Patents

Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor

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Publication number
HUP9902949A2
HUP9902949A2 HU9902949A HUP9902949A HUP9902949A2 HU P9902949 A2 HUP9902949 A2 HU P9902949A2 HU 9902949 A HU9902949 A HU 9902949A HU P9902949 A HUP9902949 A HU P9902949A HU P9902949 A2 HUP9902949 A2 HU P9902949A2
Authority
HU
Hungary
Prior art keywords
aryl
alkyl
cor4
halo
jso2r3
Prior art date
Application number
HU9902949A
Other languages
Hungarian (hu)
Inventor
Kerry Anne Cleek
William H. Darlington
Susanne R. Haadsma-Svensson
Jeffrey A. Leiby
Chiu-Hong Lin
Arthur G. Romero
Original Assignee
Pharmacia & Upjohn Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co. filed Critical Pharmacia & Upjohn Co.
Priority to HU9902949A priority Critical patent/HUP9902949A3/en
Publication of HUP9902949A2 publication Critical patent/HUP9902949A2/en
Publication of HUP9902949A3 publication Critical patent/HUP9902949A3/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Aryl and heteroaryl fused cycloalkyl-amines of formulae (I), (II), and (III), and their salts, enantiomers, and racemates, are new. When n = 1, then X = JCONR4R5, JSO2R3, JSO2NR4R5, JNR4CONHR5, JNHSO2R3, JNHCOR3, or COR4; and Y = R4, GCONR4R5, GCN, GSO2NR4R5, OR6, GSO2R3, GNHSO2R3, halo or GNHCOR3; J = (CH2)m; G = (CH2)p; m, p = 0 or 1, but, when m = 0, then Y is not H or halo; when n = 0 and Y = OR9, then X = JCONR4R5, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3 or COR4; or when n = 0 or 1, then XY in adjacent positions together = CONR10CO, CONR4(CH2)xNR10CO, CH2NR10CO, CH2CH2NR10CO, CH2CONR10, NR3CONR3, NR3COO, N=C(R7)NR3, or CH2N(R8)CH2; x = 0 or 1; R1, R2 = H, 1-8C alkyl, or aryl 1-8C alkyl; R3 = 1-8C alkyl, aryl, or aryl(1-6C alkyl); R4, R5 = H, 1-8C alkyl, aryl, or aryl(1-6C alkyl); R6 = H, 1-8C alkyl, aryl(1-6C alkyl), CF3SO2-aryl, 1-8C alkylsulphonyl, arylsulphonyl, or aryl(1-6C alkylsulphonyl); R7 = H, CONR4R4, SO2NR4R4, or SO2R4; R8 = 1-8C alkyl, aryl 1-6C alkyl, aryl, CONR4R4, COR4, SO2NR4R4, or SO2R4, provided in each case that R4 is not H; R9 = 2-8C alkyl (optionally substituted by 1-3 halo), aryl, or aryl(1-6C alkyl); and R10 = H, 1-8C alkyl, aryl, aryl(1-6C alkyl), arylsulphonyl, or arylsulphonyl(1-6C alkyl); one of A-D = N, the others = CH; k = 1 or 2; X', Y' = (i) substituted at A, B, C or D and X' = JCONR4R5, JCN, OSO2R3, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3, or COR4; Y' = R4, GCONR4R5, GCN, GSO2NR4R5, OR61, OSO2R3, GSO2R3, GNHSO2R3, halo or GNHCOR3 (provided that when m = 0, then Y' is not H or halo); (ii) jointly in adjacent positions CONR4CO, CH2NR4CO, CH2CONR4 or CH2N(R4)CH2; R61 = H, MeSO2, CF3SO2, arylsulphonyl, 1-8C alkyl, aryl, or aryl 1-6C alkyl; one of E, F = N, the other = S; X" = JCONR4R5, JCN, JSO2NR4R5, JNR4CONHR5, JSO2R3, JNHSO2R3, JNHCOR3 or COR4.
HU9902949A 1997-05-12 1997-05-12 Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor HUP9902949A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9902949A HUP9902949A3 (en) 1997-05-12 1997-05-12 Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9902949A HUP9902949A3 (en) 1997-05-12 1997-05-12 Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor

Publications (2)

Publication Number Publication Date
HUP9902949A2 true HUP9902949A2 (en) 2000-02-28
HUP9902949A3 HUP9902949A3 (en) 2000-09-28

Family

ID=89999184

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902949A HUP9902949A3 (en) 1997-05-12 1997-05-12 Aryl substituted cyclic amines as selective ligands of dopamine d3 receptor

Country Status (1)

Country Link
HU (1) HUP9902949A3 (en)

Also Published As

Publication number Publication date
HUP9902949A3 (en) 2000-09-28

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FD9A Lapse of provisional protection due to non-payment of fees