HUP9902351A2 - Solid compositions containing metoprolol and process for producing the same - Google Patents
Solid compositions containing metoprolol and process for producing the sameInfo
- Publication number
- HUP9902351A2 HUP9902351A2 HU9902351A HUP9902351A HUP9902351A2 HU P9902351 A2 HUP9902351 A2 HU P9902351A2 HU 9902351 A HU9902351 A HU 9902351A HU P9902351 A HUP9902351 A HU P9902351A HU P9902351 A2 HUP9902351 A2 HU P9902351A2
- Authority
- HU
- Hungary
- Prior art keywords
- mixing
- additives
- optionally
- metoprolol
- dry state
- Prior art date
Links
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002237 metoprolol Drugs 0.000 title abstract 3
- 239000008247 solid mixture Substances 0.000 title abstract 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 4
- 239000000654 additive Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 239000007891 compressed tablet Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A solid composition comprises: (a) 1-70 % metoprolol (M) in a non-amorphous form; (b) 10-95 % polyethylene oxide (PEO); and (c) a balance of conventional additives, excluding basic components. An Independent claim is also included for the preparation of the above composition, comprising: (i) mixing the dry state and the metoprolol (M) and the polyethylene oxide (PEO) and optionally one or more additives; (ii) optionally adding a solvent, followed by mixing; (iii) granulating the mixture; (iv) drying the granules; (v) optionally adding one or more additives with mixing in the dry state and passing it through a sieve; (vi) optionally adding one or more additives and mixing in the dry state; (vii) compressing the mixture obtained into a pressed tablet; and (viii) optionally coating the compressed tablet.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/120,914 US6048547A (en) | 1996-04-15 | 1998-07-22 | Process for manufacturing solid compositions containing polyethylene oxide and an active ingredient |
| EP98402192A EP0987020A1 (en) | 1998-09-04 | 1998-09-04 | Metoprolol composition and processes for manufacturing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9902351D0 HU9902351D0 (en) | 1999-10-28 |
| HUP9902351A2 true HUP9902351A2 (en) | 2000-12-28 |
| HUP9902351A3 HUP9902351A3 (en) | 2001-01-29 |
Family
ID=26151693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902351A HUP9902351A3 (en) | 1998-07-22 | 1999-07-12 | Solid compositions containing metoprolol and process for producing the same |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | ATE277603T1 (en) |
| BG (1) | BG64835B1 (en) |
| DE (2) | DE69920590T2 (en) |
| EA (1) | EA002188B1 (en) |
| HK (1) | HK1024873A1 (en) |
| HR (1) | HRP990230A2 (en) |
| HU (1) | HUP9902351A3 (en) |
| NO (1) | NO993588L (en) |
| PL (1) | PL334592A1 (en) |
| SK (1) | SK284766B6 (en) |
| YU (1) | YU33999A (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| ATE72111T1 (en) * | 1987-01-14 | 1992-02-15 | Ciba Geigy Ag | THERAPEUTIC SYSTEM FOR POORLY SOLUBLE ACTIVE INGREDIENTS. |
| DE69619979T2 (en) * | 1995-04-14 | 2002-11-21 | Pharma Pass Illkirch Graffenst | SOLID COMPOSITIONS WITH A NON-AMORPHOUS ACTIVE SUBSTANCE AND POLYETHYLENE OXIDE |
-
1999
- 1999-07-12 HU HU9902351A patent/HUP9902351A3/en unknown
- 1999-07-16 SK SK965-99A patent/SK284766B6/en unknown
- 1999-07-19 DE DE69920590T patent/DE69920590T2/en not_active Expired - Fee Related
- 1999-07-19 DE DE0974343T patent/DE974343T1/en active Pending
- 1999-07-19 AT AT99202373T patent/ATE277603T1/en not_active IP Right Cessation
- 1999-07-20 BG BG103595A patent/BG64835B1/en unknown
- 1999-07-21 EA EA199900583A patent/EA002188B1/en not_active IP Right Cessation
- 1999-07-21 HR HR98402192.3A patent/HRP990230A2/en not_active Application Discontinuation
- 1999-07-21 YU YU33999A patent/YU33999A/en unknown
- 1999-07-22 NO NO993588A patent/NO993588L/en not_active Application Discontinuation
- 1999-07-22 PL PL99334592A patent/PL334592A1/en not_active Application Discontinuation
-
2000
- 2000-07-06 HK HK00104152A patent/HK1024873A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SK96599A3 (en) | 2000-02-14 |
| HK1024873A1 (en) | 2000-10-27 |
| HUP9902351A3 (en) | 2001-01-29 |
| NO993588D0 (en) | 1999-07-22 |
| EA002188B1 (en) | 2002-02-28 |
| PL334592A1 (en) | 2000-01-31 |
| DE69920590D1 (en) | 2004-11-04 |
| EA199900583A2 (en) | 2000-02-28 |
| DE69920590T2 (en) | 2006-04-06 |
| DE974343T1 (en) | 2000-11-02 |
| HRP990230A2 (en) | 2000-04-30 |
| SK284766B6 (en) | 2005-11-03 |
| ATE277603T1 (en) | 2004-10-15 |
| YU33999A (en) | 2002-03-18 |
| NO993588L (en) | 2000-01-24 |
| HU9902351D0 (en) | 1999-10-28 |
| BG103595A (en) | 2000-07-31 |
| EA199900583A3 (en) | 2000-06-26 |
| BG64835B1 (en) | 2006-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |