HUP9702405A2 - Eljárás 1-(4-fluor-fenil)-1,2-difenil-1-butén előállítására - Google Patents
Eljárás 1-(4-fluor-fenil)-1,2-difenil-1-butén előállításáraInfo
- Publication number
- HUP9702405A2 HUP9702405A2 HU9702405A HUP9702405A HUP9702405A2 HU P9702405 A2 HUP9702405 A2 HU P9702405A2 HU 9702405 A HU9702405 A HU 9702405A HU P9702405 A HUP9702405 A HU P9702405A HU P9702405 A2 HUP9702405 A2 HU P9702405A2
- Authority
- HU
- Hungary
- Prior art keywords
- fluor
- butene
- diphenyl
- phenyl
- producing
- Prior art date
Links
- KDKKRJMQCQNZDY-UHFFFAOYSA-N 1-(1,2-diphenylbut-1-enyl)-4-fluorobenzene Chemical compound C=1C=CC=CC=1C(CC)=C(C=1C=CC(F)=CC=1)C1=CC=CC=C1 KDKKRJMQCQNZDY-UHFFFAOYSA-N 0.000 title 1
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya új eljárására az (I) képletű 1-(4-flűőr-fenil)-1,2-difenil-1-bűtén előállítására a (IV) képletű a-etil-dezőxibenzőin ésp-flűőr-bróm-benzőlból képezett Grignard-reagens reakciója útján, őlymódőn , hőgy a reakcióhőz a (IV) képletű a-etil-dezőxibenzőin és a(III) képletű dezőxibenzőin keverékét alkalmazzák. Az (I) képletűvegyület értékes gyógyszeripari közbenső termék, amely a tamőxifenszabadnevű, emlőrák kezelésére felhasználható hatóanyag előállításánálnyerhet felhasználást. Az eljárás előnye, hőgy a (IV) képletű a-etil-dezőxibenzőin tisztítására nincs szükség. Kiindűlási anyagkéntdezőxibenzőinkeverék felhasználása esetén is magas kitermelésselnagytisztaságú, (I) képletű vegyületet nyernek. (III) ŕ
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9702405A HU227156B1 (en) | 1997-12-11 | 1997-12-11 | Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9702405A HU227156B1 (en) | 1997-12-11 | 1997-12-11 | Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene |
Publications (4)
Publication Number | Publication Date |
---|---|
HU9702405D0 HU9702405D0 (en) | 1998-03-02 |
HUP9702405A2 true HUP9702405A2 (hu) | 2000-06-28 |
HUP9702405A3 HUP9702405A3 (en) | 2002-05-28 |
HU227156B1 HU227156B1 (en) | 2010-09-28 |
Family
ID=89995852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9702405A HU227156B1 (en) | 1997-12-11 | 1997-12-11 | Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene |
Country Status (1)
Country | Link |
---|---|
HU (1) | HU227156B1 (hu) |
-
1997
- 1997-12-11 HU HU9702405A patent/HU227156B1/hu not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU9702405D0 (en) | 1998-03-02 |
HUP9702405A3 (en) | 2002-05-28 |
HU227156B1 (en) | 2010-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC9A | Change of name, address |
Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU |
|
MM4A | Lapse of definitive patent protection due to non-payment of fees |