HUP9702405A2 - Eljárás 1-(4-fluor-fenil)-1,2-difenil-1-butén előállítására - Google Patents

Eljárás 1-(4-fluor-fenil)-1,2-difenil-1-butén előállítására

Info

Publication number
HUP9702405A2
HUP9702405A2 HU9702405A HUP9702405A HUP9702405A2 HU P9702405 A2 HUP9702405 A2 HU P9702405A2 HU 9702405 A HU9702405 A HU 9702405A HU P9702405 A HUP9702405 A HU P9702405A HU P9702405 A2 HUP9702405 A2 HU P9702405A2
Authority
HU
Hungary
Prior art keywords
fluor
butene
diphenyl
phenyl
producing
Prior art date
Application number
HU9702405A
Other languages
English (en)
Inventor
János Hanák
Ferenc Jurák
Béláné Fertődi
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9702405A priority Critical patent/HU227156B1/hu
Publication of HU9702405D0 publication Critical patent/HU9702405D0/hu
Publication of HUP9702405A2 publication Critical patent/HUP9702405A2/hu
Publication of HUP9702405A3 publication Critical patent/HUP9702405A3/hu
Publication of HU227156B1 publication Critical patent/HU227156B1/hu

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgya új eljárására az (I) képletű 1-(4-flűőr-fenil)-1,2-difenil-1-bűtén előállítására a (IV) képletű a-etil-dezőxibenzőin ésp-flűőr-bróm-benzőlból képezett Grignard-reagens reakciója útján, őlymódőn , hőgy a reakcióhőz a (IV) képletű a-etil-dezőxibenzőin és a(III) képletű dezőxibenzőin keverékét alkalmazzák. Az (I) képletűvegyület értékes gyógyszeripari közbenső termék, amely a tamőxifenszabadnevű, emlőrák kezelésére felhasználható hatóanyag előállításánálnyerhet felhasználást. Az eljárás előnye, hőgy a (IV) képletű a-etil-dezőxibenzőin tisztítására nincs szükség. Kiindűlási anyagkéntdezőxibenzőinkeverék felhasználása esetén is magas kitermelésselnagytisztaságú, (I) képletű vegyületet nyernek. (III) ŕ
HU9702405A 1997-12-11 1997-12-11 Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene HU227156B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU9702405A HU227156B1 (en) 1997-12-11 1997-12-11 Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9702405A HU227156B1 (en) 1997-12-11 1997-12-11 Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene

Publications (4)

Publication Number Publication Date
HU9702405D0 HU9702405D0 (en) 1998-03-02
HUP9702405A2 true HUP9702405A2 (hu) 2000-06-28
HUP9702405A3 HUP9702405A3 (en) 2002-05-28
HU227156B1 HU227156B1 (en) 2010-09-28

Family

ID=89995852

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702405A HU227156B1 (en) 1997-12-11 1997-12-11 Process for producing 1-(4-fluor-phenyl)-1,2-diphenyl-1-butene

Country Status (1)

Country Link
HU (1) HU227156B1 (hu)

Also Published As

Publication number Publication date
HU9702405D0 (en) 1998-03-02
HUP9702405A3 (en) 2002-05-28
HU227156B1 (en) 2010-09-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

MM4A Lapse of definitive patent protection due to non-payment of fees