HUP0401658A2 - Human tissue factor antibodies - Google Patents

Human tissue factor antibodies

Info

Publication number
HUP0401658A2
HUP0401658A2 HU0401658A HUP0401658A HUP0401658A2 HU P0401658 A2 HUP0401658 A2 HU P0401658A2 HU 0401658 A HU0401658 A HU 0401658A HU P0401658 A HUP0401658 A HU P0401658A HU P0401658 A2 HUP0401658 A2 HU P0401658A2
Authority
HU
Hungary
Prior art keywords
tissue factor
human tissue
factor antibodies
antibodies
fviia
Prior art date
Application number
HU0401658A
Other languages
Hungarian (hu)
Inventor
Per-Ola Freskgaard
Jes Thorn Clausen
Brit Binow Sorensen
Marianne Kjalke
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP0401658A2 publication Critical patent/HUP0401658A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány teljesen humán ellenanyagokkal foglalkozik, melyek aszöveti faktorral (TF) immunológiai reakcióba lépnek, így a VIIavéralvadási faktor (FVIIa) kötődését gátolják. ÓThe invention deals with fully human antibodies, which enter into an immunological reaction with tissue factor (TF), thus inhibiting the binding of coagulation factor VIIa (FVIIa). HE

HU0401658A 2001-10-02 2002-09-30 Human tissue factor antibodies HUP0401658A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101437 2001-10-02
PCT/DK2002/000644 WO2003029295A1 (en) 2001-10-02 2002-09-30 Human tissue factor antibodies

Publications (1)

Publication Number Publication Date
HUP0401658A2 true HUP0401658A2 (en) 2004-11-29

Family

ID=8160743

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401658A HUP0401658A2 (en) 2001-10-02 2002-09-30 Human tissue factor antibodies

Country Status (15)

Country Link
EP (1) EP1434802A1 (en)
JP (1) JP2005512970A (en)
KR (1) KR20040045478A (en)
CN (1) CN1575302A (en)
BR (1) BR0213046A (en)
CA (1) CA2460917A1 (en)
CZ (1) CZ2004454A3 (en)
HU (1) HUP0401658A2 (en)
IL (1) IL160998A0 (en)
MX (1) MXPA04003051A (en)
NO (1) NO20041802L (en)
PL (1) PL368989A1 (en)
RU (1) RU2004113373A (en)
WO (1) WO2003029295A1 (en)
ZA (1) ZA200402303B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109680A1 (en) 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US5986065A (en) 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US7749498B2 (en) 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
WO2002078738A1 (en) * 2001-03-26 2002-10-10 Koji Suzuki Blood rheology improving agents
AU2003277832A1 (en) * 2002-10-31 2004-05-25 Novo Nordisk A/S Humanized tissue factor antibodies
EP1587549A2 (en) * 2003-01-22 2005-10-26 Novo Nordisk A/S Radiolabelled tissue factor binding agent and the use thereof
US7605235B2 (en) 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
BRPI0410875A (en) * 2003-05-30 2006-07-04 Centocor Inc Tumor Factor Growth Inhibition Method
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
AU2004255553B2 (en) * 2003-06-19 2009-08-20 Genentech, Inc. Compositions and methods for treating coagulation related disorders
AU2004268648A1 (en) * 2003-08-29 2005-03-10 Centocor, Inc. Method of promoting graft survival with anti-tissue factor antibodies
JP2007523099A (en) * 2004-02-20 2007-08-16 ノボ　ノルディスク　アクティーゼルスカブ Combination therapy
UA115964C2 (en) 2006-09-08 2018-01-25 Еббві Айрленд Анлімітед Компані INTERLAYKIN-13-Binding Protein
CN101423552B (en) * 2008-02-29 2012-05-16 复旦大学 Human-derived anti-human tissue factor Fab and preparation method thereof
AU2016277670B2 (en) * 2008-12-09 2019-02-07 Genmab A/S Human antibodies against tissue factor
AU2013203150B2 (en) * 2008-12-09 2016-09-22 Genmab A/S Human antibodies against tissue factor
UA109633C2 (en) 2008-12-09 2015-09-25 HUMAN ANTIBODY AGAINST TISSUE FACTOR
WO2010131235A1 (en) * 2009-05-15 2010-11-18 University Of The Free State Inhibitory antibody fragments to human tissue factor
NZ604718A (en) * 2010-06-15 2015-01-30 Genmab As Human antibody drug conjugates against tissue factor
US8722044B2 (en) 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
WO2018036117A1 (en) * 2016-08-22 2018-03-01 复旦大学 Antibody targeted to tissue factor, preparation method therefor, and use thereof
WO2017028823A1 (en) * 2015-08-20 2017-02-23 复旦大学 Antibody targeted against tissue factor, preparation method therefor, and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001978A (en) * 1987-03-31 1999-12-14 The Scripps Research Institute Human tissue factor related DNA segments polypeptides and antibodies
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
JP2779193B2 (en) * 1989-02-02 1998-07-23 帝人株式会社 Anti-human tissue factor monoclonal antibody
WO1996040921A1 (en) * 1995-06-07 1996-12-19 Ortho Farmaceutical Corporation Cdr-grafted anti-tissue factor antibodies and methods of use thereof
SK14812000A3 (en) * 1998-04-03 2001-08-06 Chugai Seiyaku Kabushiki Kaisha HUMANIZED ANTIBODY AGAINST HUMAN TISSUE FACTOR (TF) AND PROCESSì (54) FOR CONSTRUCTING HUMANIZED ANTIBODY
CA2388408A1 (en) * 1999-10-01 2001-04-12 Chugai Seiyaku Kabushiki Kaisha Prevention and treatment of diseases associated with blood coagulation
CA2402596A1 (en) * 2000-03-16 2001-09-27 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency

Also Published As

Publication number Publication date
EP1434802A1 (en) 2004-07-07
NO20041802L (en) 2004-04-30
JP2005512970A (en) 2005-05-12
BR0213046A (en) 2005-06-28
IL160998A0 (en) 2004-08-31
ZA200402303B (en) 2004-11-25
PL368989A1 (en) 2005-04-04
CN1575302A (en) 2005-02-02
WO2003029295A1 (en) 2003-04-10
KR20040045478A (en) 2004-06-01
CZ2004454A3 (en) 2004-09-15
RU2004113373A (en) 2005-03-27
MXPA04003051A (en) 2004-07-05
CA2460917A1 (en) 2003-04-10

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees