HUP0204003A2 - Biodegradable microparticles with novel erythropoietin stimulating protein - Google Patents
Biodegradable microparticles with novel erythropoietin stimulating proteinInfo
- Publication number
- HUP0204003A2 HUP0204003A2 HU0204003A HUP0204003A HUP0204003A2 HU P0204003 A2 HUP0204003 A2 HU P0204003A2 HU 0204003 A HU0204003 A HU 0204003A HU P0204003 A HUP0204003 A HU P0204003A HU P0204003 A2 HUP0204003 A2 HU P0204003A2
- Authority
- HU
- Hungary
- Prior art keywords
- stimulating protein
- erythropoietin stimulating
- biodegradable microparticles
- novel erythropoietin
- nesp
- Prior art date
Links
- 102000003951 Erythropoietin Human genes 0.000 title abstract 2
- 108090000394 Erythropoietin Proteins 0.000 title abstract 2
- 229940105423 erythropoietin Drugs 0.000 title abstract 2
- 239000011859 microparticle Substances 0.000 title abstract 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000004936 stimulating effect Effects 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
A jelen találmány a biológiailag aktív, új eritropoietin stimulálóprotein (NESP) hosszantartó felszabadulására szolgáló készítménnyelkapcsolatos, valamint az említett készítmény előállítására szolgálójavított módszerekkel. A készítmény polimer mikrorészecskékettartalmaz, melyeken belül a NESP-részecskéket diszpergálták. Ajavított módszer egy koszolvens elegyet alkalmaz a maradvány polimeroldószerek bármilyen szárítási folyamat alatti még hatékonyabb ésgyorsabb eltávolításának biztosítása céljából. ÓThe present invention relates to a formulation for sustained release of biologically active novel erythropoietin stimulating protein (NESP) and to improved methods for producing said formulation. The preparation contains polymer microparticles, within which the NESP particles have been dispersed. An improved method uses a cosolvent mixture to ensure even more efficient and faster removal of residual polymer solvents during any drying process. HE
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42656699A | 1999-10-22 | 1999-10-22 | |
| US68798100A | 2000-10-13 | 2000-10-13 | |
| PCT/US2000/029257 WO2001030320A1 (en) | 1999-10-22 | 2000-10-23 | Biodegradable microparticles with novel erythropoietin stimulating protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0204003A2 true HUP0204003A2 (en) | 2003-03-28 |
Family
ID=27027100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204003A HUP0204003A2 (en) | 1999-10-22 | 2000-10-23 | Biodegradable microparticles with novel erythropoietin stimulating protein |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1221942A1 (en) |
| JP (1) | JP2003531106A (en) |
| KR (1) | KR20020063882A (en) |
| CN (1) | CN1411369A (en) |
| CA (1) | CA2387229A1 (en) |
| HK (1) | HK1049113A1 (en) |
| HU (1) | HUP0204003A2 (en) |
| IL (1) | IL149036A0 (en) |
| MX (1) | MXPA02003820A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428142B (en) * | 2007-11-08 | 2011-09-14 | 江苏先声药物研究有限公司 | Process for producing recombinant human vascular endothelial inhibitor composition sustained-release microsphere |
| WO2023040792A1 (en) * | 2021-09-14 | 2023-03-23 | 杰科（天津）生物医药有限公司 | Preparation method for erythropoietin |
| WO2023098844A1 (en) * | 2021-12-03 | 2023-06-08 | 杰科（天津）生物医药有限公司 | Formulation, and preparation method therefor and use thereof |
-
2000
- 2000-10-23 MX MXPA02003820A patent/MXPA02003820A/en unknown
- 2000-10-23 CA CA002387229A patent/CA2387229A1/en not_active Abandoned
- 2000-10-23 CN CN00817320A patent/CN1411369A/en active Pending
- 2000-10-23 KR KR1020027005079A patent/KR20020063882A/en not_active Application Discontinuation
- 2000-10-23 EP EP00973798A patent/EP1221942A1/en not_active Withdrawn
- 2000-10-23 JP JP2001532740A patent/JP2003531106A/en not_active Withdrawn
- 2000-10-23 HU HU0204003A patent/HUP0204003A2/en unknown
- 2000-10-23 IL IL14903600A patent/IL149036A0/en unknown
-
2003
- 2003-01-13 HK HK03100291.3A patent/HK1049113A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2387229A1 (en) | 2001-05-03 |
| IL149036A0 (en) | 2002-11-10 |
| EP1221942A1 (en) | 2002-07-17 |
| JP2003531106A (en) | 2003-10-21 |
| MXPA02003820A (en) | 2003-07-14 |
| HK1049113A1 (en) | 2003-05-02 |
| CN1411369A (en) | 2003-04-16 |
| KR20020063882A (en) | 2002-08-05 |
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