HUP0203582A2 - Polymorphic n-[3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl]-4-nitro benzamide hydrochloride, process for its preparation, pharmaceutical composition comprising thereof and its use - Google Patents

Polymorphic n-[3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl]-4-nitro benzamide hydrochloride, process for its preparation, pharmaceutical composition comprising thereof and its use

Info

Publication number
HUP0203582A2
HUP0203582A2 HU0203582A HUP0203582A HUP0203582A2 HU P0203582 A2 HUP0203582 A2 HU P0203582A2 HU 0203582 A HU0203582 A HU 0203582A HU P0203582 A HUP0203582 A HU P0203582A HU P0203582 A2 HUP0203582 A2 HU P0203582A2
Authority
HU
Hungary
Prior art keywords
propyl
ethyl
amino
dimethoxyphenyl
polymorphic form
Prior art date
Application number
HU0203582A
Other languages
Hungarian (hu)
Inventor
David Busby
Original Assignee
Glaxosmithkline Lab Sas
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Lab Sas, Smithkline Beecham Plc filed Critical Glaxosmithkline Lab Sas
Publication of HUP0203582A2 publication Critical patent/HUP0203582A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány az N-[3-{[2-(3,4-dimetoxi-fenil)-etil]-amino}-propil]-4-nitro-benzamid-hidroklorid új polimorf formájára vonatkozik. Az újpolimorf formát úgy állítják elő, hogy az N-[3-{[2-(3,4-dimetoxi-fenil)-etil]-amino}-propil]-4-nitro-benzamid-hidrokloridotacetonitrilből kristályosítják, majd a termékből eltávolítják azacetonitrilt. A találmány kiterjed az új polimorf forma előállításieljárására, az új polimorf formát tartalmazó gyógyszerkészítményekre,valamint az új polimorf forma gyógyászati alkalmazására is. Az újpolimorf forma szívaritmia és ischaemiás ritmuszavarok kezelésérealkalmazható. ÓThe invention relates to a new polymorphic form of N-[3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-propyl]-4-nitrobenzamide hydrochloride. The new polymorph form is prepared by crystallizing from N-[3-{[2-(3,4-dimethoxyphenyl)ethyl]-amino}-propyl]-4-nitrobenzamide hydrochloride acetonitrile and then removing the product azacetonitrile. The invention covers the production process of the new polymorphic form, pharmaceutical preparations containing the new polymorphic form, as well as the medicinal use of the new polymorphic form. The new polymorphic form can be used to treat cardiac arrhythmias and ischemic rhythm disorders. HE

HU0203582A 1999-10-08 2000-10-06 Polymorphic n-[3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl]-4-nitro benzamide hydrochloride, process for its preparation, pharmaceutical composition comprising thereof and its use HUP0203582A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923933.7A GB9923933D0 (en) 1999-10-08 1999-10-08 Novel pharmaceutical
PCT/GB2000/003847 WO2001027071A1 (en) 1999-10-08 2000-10-06 Polymorphic n-[3-[[2-(3,4-dimethoxyphenyl) ethyl] amino] propyl] -4-nitro benzamide hydrochloride

Publications (1)

Publication Number Publication Date
HUP0203582A2 true HUP0203582A2 (en) 2004-03-01

Family

ID=10862442

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203582A HUP0203582A2 (en) 1999-10-08 2000-10-06 Polymorphic n-[3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl]-4-nitro benzamide hydrochloride, process for its preparation, pharmaceutical composition comprising thereof and its use

Country Status (18)

Country Link
EP (1) EP1218334A1 (en)
JP (1) JP2003511437A (en)
KR (1) KR20020043618A (en)
CN (1) CN1384817A (en)
AU (1) AU7546000A (en)
BR (1) BR0014591A (en)
CA (1) CA2386845A1 (en)
CZ (1) CZ20021189A3 (en)
GB (1) GB9923933D0 (en)
HK (1) HK1049147A1 (en)
HU (1) HUP0203582A2 (en)
IL (1) IL148966A0 (en)
MX (1) MXPA02003516A (en)
NO (1) NO20021639L (en)
PL (1) PL354137A1 (en)
TR (1) TR200200949T2 (en)
WO (1) WO2001027071A1 (en)
ZA (1) ZA200202679B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2412306T3 (en) * 2002-01-09 2013-07-11 Emisphere Technologies, Inc. Sodium 4 - ((4-Chloro-2-hydroxybenzoyl) amino) butanoate polymorphs
JP5495787B2 (en) * 2006-12-06 2014-05-21 クオナトウス ファーマシューティカルズ，インコーポレイテッド (3S) -3- [N- (N ′-(2-tert-butylphenyl) oxamil) alaninyl] amino-5- (2 ′, 3 ′, 5 ′, 6′-tetrafluorophenoxy) -4-oxo Crystal form of pentanoic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2726267B1 (en) * 1994-10-26 1998-01-02 Smithkline Beecham Lab NOVEL ARRHYTHMIC AGENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR PREPARING THEM
GB9706376D0 (en) * 1997-03-27 1997-05-14 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
AU7546000A (en) 2001-04-23
ZA200202679B (en) 2003-05-28
HK1049147A1 (en) 2003-05-02
NO20021639D0 (en) 2002-04-05
TR200200949T2 (en) 2002-08-21
BR0014591A (en) 2002-06-11
MXPA02003516A (en) 2004-09-10
CZ20021189A3 (en) 2002-09-11
EP1218334A1 (en) 2002-07-03
CN1384817A (en) 2002-12-11
PL354137A1 (en) 2003-12-29
CA2386845A1 (en) 2001-04-19
GB9923933D0 (en) 1999-12-08
JP2003511437A (en) 2003-03-25
IL148966A0 (en) 2002-11-10
WO2001027071A1 (en) 2001-04-19
NO20021639L (en) 2002-05-30
KR20020043618A (en) 2002-06-10

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HUP0203582A2 (en) Polymorphic n-[3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl]-4-nitro benzamide hydrochloride, process for its preparation, pharmaceutical composition comprising thereof and its use
Wiesner et al. Discovery of a novel lead structure for anti-malarials