HUP0203537A2 - Methods of producing a target molecule in a transgenic animal and purification of the target molecule - Google Patents
Methods of producing a target molecule in a transgenic animal and purification of the target moleculeInfo
- Publication number
- HUP0203537A2 HUP0203537A2 HU0203537A HUP0203537A HUP0203537A2 HU P0203537 A2 HUP0203537 A2 HU P0203537A2 HU 0203537 A HU0203537 A HU 0203537A HU P0203537 A HUP0203537 A HU P0203537A HU P0203537 A2 HUP0203537 A2 HU P0203537A2
- Authority
- HU
- Hungary
- Prior art keywords
- target molecule
- purification
- methods
- transgenic animal
- producing
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Analytical Chemistry (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A találmány tárgyát biológiai rendszerekben található célmolekulákelőállítására és tisztítására szolgáló rendszerek és eljárásokképezik. Közelebbről, a találmány tárgyát megköthető epitópottartalmazó célpolipeptid tisztítására szolgáló, egy vagy többmultivalens kötőpolipeptidet és mátrixot alkalmazó,transzgénikusállat-alapú rendszerek és eljárások képezik. A találmánytárgyát képezik továbbá maguk a transzgenikus állatok is. ÓThe subject of the invention is systems and methods for the production and purification of target molecules in biological systems. More specifically, the subject of the invention is transgenic animal-based systems and methods for the purification of a target polypeptide containing a bindable epitope, using one or more multivalent binding polypeptides and a matrix. The invention also includes the transgenic animals themselves. HE
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15974899P | 1999-10-14 | 1999-10-14 | |
US20466200P | 2000-05-17 | 2000-05-17 | |
PCT/US2000/028589 WO2001026455A1 (en) | 1999-10-14 | 2000-10-16 | Methods of producing a target molecule in a transgenic animal and purification of the target molecule |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0203537A2 true HUP0203537A2 (en) | 2003-02-28 |
Family
ID=26856252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203537A HUP0203537A2 (en) | 1999-10-14 | 2000-10-16 | Methods of producing a target molecule in a transgenic animal and purification of the target molecule |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP1220606A4 (en) |
JP (1) | JP2003511048A (en) |
KR (1) | KR100772465B1 (en) |
CN (1) | CN1322003C (en) |
AU (1) | AU781944B2 (en) |
BR (1) | BR0014860A (en) |
CA (1) | CA2382741A1 (en) |
HU (1) | HUP0203537A2 (en) |
IL (1) | IL149003A0 (en) |
MX (1) | MXPA02003702A (en) |
NO (1) | NO20021686L (en) |
NZ (1) | NZ518263A (en) |
RU (1) | RU2002112460A (en) |
WO (1) | WO2001026455A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6800462B2 (en) * | 2001-09-10 | 2004-10-05 | Abgenomics Corporation | Production of recombinant proteins in vivo and use for generating antibodies |
US20030049694A1 (en) * | 2001-09-10 | 2003-03-13 | Chung-Hsiun Wu | Production of fusion proteins and use for identifying binding molecules |
CN1283785C (en) * | 2002-05-20 | 2006-11-08 | 上海杰隆生物工程股份有限公司 | Method of producing human forcing erythrogenin using transgene animal mammary gland |
US20070056050A1 (en) * | 2005-06-29 | 2007-03-08 | Clokie Cameron M L | PRODUCTION OF BONE MORPHOGENIC PROTEINS (BMPs) IN TRANSGENIC MAMMALS |
MX2009013421A (en) * | 2007-06-13 | 2010-03-22 | Sterrenbeld Biotechnologie North America Inc | Transgenic mammals that produce exogenous proteins in milk. |
WO2010036976A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of antibodies |
WO2010036978A2 (en) | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of growth hormone |
US9150881B2 (en) | 2009-04-09 | 2015-10-06 | Proteovec Holding, L.L.C. | Production of proteins using transposon-based vectors |
KR20140132706A (en) * | 2011-12-19 | 2014-11-18 | 엘에프비 유에스에이, 인크. | Recombinant human alpha-1-antitrypsin for the treatment of inflammatory disorders |
EP2956480B1 (en) | 2013-02-13 | 2019-09-04 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
AR094778A1 (en) | 2013-02-13 | 2015-08-26 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | PROTEINS WITH MODIFIED GLYCOSILATION AND METHODS FOR PRODUCERS |
CA2916566A1 (en) | 2013-07-05 | 2015-01-08 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Affinity chromatography matrix |
FR3025515B1 (en) | 2014-09-05 | 2016-09-09 | Lab Francais Du Fractionnement | PROCESS FOR PURIFYING MONOCLONAL ANTIBODY |
FR3034420A1 (en) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | ANTI-CD303 MONOCLONAL ANTIBODIES |
JP6712125B2 (en) * | 2015-09-04 | 2020-06-17 | 株式会社フジクラ | Connection structure of oxide superconducting wire and method for manufacturing the same |
FR3060395B1 (en) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | COMBINATION OF ANTI-CD303 AND ANTI-HER2 ANTIBODIES |
FR3060394B1 (en) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | COMBINATION OF ANTI-CD303 AND ANTI-AMHRII ANTIBODIES |
FR3076294B1 (en) | 2017-12-29 | 2022-01-28 | Lab Francais Du Fractionnement | METHOD FOR PURIFYING ANTIBODIES FROM RAW MILK |
CA3223956A1 (en) | 2021-12-20 | 2023-06-29 | Vetoquinol Sa | Anti-canine interleukine-31-receptor a (il-31ra) antibodies and the uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK580789D0 (en) * | 1989-11-20 | 1989-11-20 | Novo Nordisk As | PROCEDURE FOR PURIFICATION OF POLYPEPTIDES |
US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
CN1114357A (en) * | 1994-07-01 | 1996-01-03 | 唐勇炜 | Process for producing recombinative polypeptide using transgene animal |
-
2000
- 2000-10-16 EP EP00970945A patent/EP1220606A4/en not_active Withdrawn
- 2000-10-16 JP JP2001529255A patent/JP2003511048A/en active Pending
- 2000-10-16 RU RU2002112460/13A patent/RU2002112460A/en unknown
- 2000-10-16 AU AU80254/00A patent/AU781944B2/en not_active Ceased
- 2000-10-16 IL IL14900300A patent/IL149003A0/en unknown
- 2000-10-16 KR KR1020027004804A patent/KR100772465B1/en not_active IP Right Cessation
- 2000-10-16 WO PCT/US2000/028589 patent/WO2001026455A1/en active IP Right Grant
- 2000-10-16 CN CNB008152802A patent/CN1322003C/en not_active Expired - Fee Related
- 2000-10-16 CA CA002382741A patent/CA2382741A1/en not_active Abandoned
- 2000-10-16 BR BR0014860-1A patent/BR0014860A/en not_active Application Discontinuation
- 2000-10-16 MX MXPA02003702A patent/MXPA02003702A/en not_active Application Discontinuation
- 2000-10-16 HU HU0203537A patent/HUP0203537A2/en unknown
- 2000-10-16 NZ NZ518263A patent/NZ518263A/en unknown
-
2002
- 2002-04-10 NO NO20021686A patent/NO20021686L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU781944B2 (en) | 2005-06-23 |
EP1220606A4 (en) | 2004-04-14 |
RU2002112460A (en) | 2004-02-27 |
BR0014860A (en) | 2003-07-08 |
IL149003A0 (en) | 2002-11-10 |
CN1387399A (en) | 2002-12-25 |
NZ518263A (en) | 2004-03-26 |
KR20030022759A (en) | 2003-03-17 |
EP1220606A1 (en) | 2002-07-10 |
WO2001026455A1 (en) | 2001-04-19 |
JP2003511048A (en) | 2003-03-25 |
NO20021686L (en) | 2002-06-12 |
CN1322003C (en) | 2007-06-20 |
MXPA02003702A (en) | 2002-09-18 |
NO20021686D0 (en) | 2002-04-10 |
AU8025400A (en) | 2001-04-23 |
KR100772465B1 (en) | 2007-11-02 |
CA2382741A1 (en) | 2001-04-19 |
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