HUP0202714A2 - Radiopharmaceutical products and their preparation procedure - Google Patents
Radiopharmaceutical products and their preparation procedureInfo
- Publication number
- HUP0202714A2 HUP0202714A2 HU0202714A HUP0202714A HUP0202714A2 HU P0202714 A2 HUP0202714 A2 HU P0202714A2 HU 0202714 A HU0202714 A HU 0202714A HU P0202714 A HUP0202714 A HU P0202714A HU P0202714 A2 HUP0202714 A2 HU P0202714A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- polysaccharide
- aromatic
- complexing
- diagnosis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
- 230000002799 radiopharmaceutical effect Effects 0.000 title 1
- 150000004676 glycans Chemical class 0.000 abstract 4
- 229920001282 polysaccharide Polymers 0.000 abstract 4
- 239000005017 polysaccharide Substances 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 230000000536 complexating effect Effects 0.000 abstract 3
- 238000003745 diagnosis Methods 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 230000002285 radioactive effect Effects 0.000 abstract 2
- 238000001959 radiotherapy Methods 0.000 abstract 2
- 229920000945 Amylopectin Polymers 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052691 Erbium Inorganic materials 0.000 abstract 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052772 Samarium Inorganic materials 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 abstract 1
- 229910052733 gallium Inorganic materials 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 238000009549 lung scintigraphy Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000011859 microparticle Substances 0.000 abstract 1
- 229910052702 rhenium Inorganic materials 0.000 abstract 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 abstract 1
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 229910052713 technetium Inorganic materials 0.000 abstract 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
- 229910052727 yttrium Inorganic materials 0.000 abstract 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány tárgyát a diagnózis vagy a terápia céljaira szolgálósugárterápiai termékek, az előállításukra irányuló eljárás és ezekettartalmazó készlet képezi. A sugárterápiai termékre jellemző, hogy ezegy poliszacharid, komplexképző csoportokkal, amelyek kovalenskötésekkel kapcsolódnak a poliszacharidhoz; ilyen az R-NH-, R-N= vagyR-N/R'/-N= csoport, ahol R jelentése szénhidrogén vagy aromás csoport,legalább 1 kénatommal és R' jelentése hidrogénatom vagy alkilcsoport,pl. metilcsoport, mi mellett a komplexképző csoportok kelát típusúkomplexet képeznek egy radioaktív fémmel, amilyen a technécium,rénium, réz, ittrium, erbium, gallium és a szamárium, és ebben akomplexben a poliszacharid mikrorészecskék alakjában van jelen. Akomplexképző csoport az al, a2, a3, a4, a5 vagy a6 képlettel írhatóle; e képletekben az R helyettesítők jelentése egymástól függetlenülhidrogénatom, adott esetben telítetlen szénhidrogén csoport, karboxil-csoport vagy aromás csoport, az a4-ben szereplő gyűrűs csoport aromás,adott esetben egy vagy több heteroatommal, és n értéke 1-5 közöttiegész szám. A poliszacharid természetes keményítő, cellulóz vagytérhálósított amilopektin. A diagnózis céljából alkalmazott, pl. atüdő szcintigráfiához felhasználható termékben a radioaktív fém 99mTcvagy 67Ga. ÓThe subject of the invention is radiation therapy products for the purposes of diagnosis or therapy, the process for their production and a kit containing them. The radiation therapy product is characterized by the fact that it is a polysaccharide with complexing groups that are covalently linked to the polysaccharide; such is the group R-NH-, R-N= or R-N/R'/-N=, where R is a hydrocarbon or an aromatic group with at least 1 sulfur atom and R' is a hydrogen atom or an alkyl group, e.g. methyl group, besides the complexing groups form a chelate type complex with a radioactive metal such as technetium, rhenium, copper, yttrium, erbium, gallium and samarium, and in this complex the polysaccharide is present in the form of microparticles. A complexing group can be written with the formula al, a2, a3, a4, a5 or a6; in these formulas, the R substituents independently mean a hydrogen atom, optionally an unsaturated hydrocarbon group, a carboxyl group or an aromatic group, the ring group in a4 is aromatic, optionally with one or more heteroatoms, and n is an integer between 1 and 5. The polysaccharide is a natural starch, cellulose or cross-linked amylopectin. Used for diagnosis, e.g. in the product that can be used for lung scintigraphy, the radioactive metal is 99mTc or 67Ga. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9910970A FR2797769B1 (en) | 1999-09-01 | 1999-09-01 | RADIOPHARMACEUTICAL PRODUCTS AND THEIR PREPARATION PROCESS |
| PCT/IB2000/001161 WO2001015746A1 (en) | 1999-09-01 | 2000-08-23 | Radiopharmaceutical products and their preparation procedure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0202714A2 true HUP0202714A2 (en) | 2002-12-28 |
Family
ID=9549465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202714A HUP0202714A2 (en) | 1999-09-01 | 2000-08-23 | Radiopharmaceutical products and their preparation procedure |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1210127A1 (en) |
| JP (1) | JP2003508455A (en) |
| KR (1) | KR20020040799A (en) |
| CN (1) | CN1371292A (en) |
| AU (1) | AU6463100A (en) |
| BG (1) | BG106438A (en) |
| BR (1) | BR0013729A (en) |
| CA (1) | CA2383517A1 (en) |
| CZ (1) | CZ2002782A3 (en) |
| EA (1) | EA200200307A1 (en) |
| EE (1) | EE200200105A (en) |
| FR (1) | FR2797769B1 (en) |
| HK (1) | HK1044893A1 (en) |
| HU (1) | HUP0202714A2 (en) |
| IL (1) | IL148076A0 (en) |
| MX (1) | MXPA02001923A (en) |
| NO (1) | NO20021001L (en) |
| NZ (1) | NZ517377A (en) |
| PL (1) | PL353803A1 (en) |
| SK (1) | SK2772002A3 (en) |
| WO (1) | WO2001015746A1 (en) |
| YU (1) | YU14202A (en) |
| ZA (1) | ZA200201057B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7842377B2 (en) | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
| US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
| US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
| US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| FR2919189A1 (en) * | 2007-07-26 | 2009-01-30 | Cyclopharma Sa Lab | NOVEL COMPOSITIONS BASED ON POLYOSIDES GRAFTED BY POLYAMINE OR POLYSOUFRE COMPOUNDS. |
| CN102977174B (en) * | 2012-12-19 | 2015-04-22 | 北京师范大学 | 99mTc(CO)3 nuclear-labeled macrocyclic polyamine triazole ring glucose-based complex as well as preparation and application of complex |
| PL240772B1 (en) | 2018-06-11 | 2022-06-06 | Nanothea Spolka Akcyjna | Method of producing polymer nanoparticles chelating radioactive isotopes for use in diagnostics and treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7412164L (en) * | 1974-09-27 | 1976-03-29 | Pharmacia Ab | FUNDS FOR INTRAVASCULAR ADMINISTRATION |
| US5672334A (en) * | 1991-01-16 | 1997-09-30 | Access Pharmaceuticals, Inc. | Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans |
| JPH08501097A (en) * | 1992-09-04 | 1996-02-06 | ザ ゼネラル ホスピタル コーポレーション | Biocompatible polymers including clinical diagnostic and therapeutic moieties |
| US5958372A (en) * | 1994-06-28 | 1999-09-28 | Nycomed Imaging As | Low viscosity chelating polymers for diagnostic imaging |
| FR2736834B1 (en) * | 1995-07-17 | 1997-08-29 | Cis Bio Int | RADIOPHARMACEUTICAL PRODUCTS WITH CARDIAC TROPISM COMPRISING A NITRURO COMPLEX OF A TRANSITIONAL METAL AND HAVING FAST MYOCARDIAL CLEARANCE |
-
1999
- 1999-09-01 FR FR9910970A patent/FR2797769B1/en not_active Expired - Fee Related
-
2000
- 2000-08-23 YU YU14202A patent/YU14202A/en unknown
- 2000-08-23 CN CN00812300A patent/CN1371292A/en active Pending
- 2000-08-23 PL PL00353803A patent/PL353803A1/en unknown
- 2000-08-23 SK SK277-2002A patent/SK2772002A3/en unknown
- 2000-08-23 MX MXPA02001923A patent/MXPA02001923A/en not_active Application Discontinuation
- 2000-08-23 BR BR0013729-4A patent/BR0013729A/en not_active IP Right Cessation
- 2000-08-23 EE EEP200200105A patent/EE200200105A/en unknown
- 2000-08-23 IL IL14807600A patent/IL148076A0/en unknown
- 2000-08-23 CZ CZ2002782A patent/CZ2002782A3/en unknown
- 2000-08-23 EA EA200200307A patent/EA200200307A1/en unknown
- 2000-08-23 JP JP2001520157A patent/JP2003508455A/en active Pending
- 2000-08-23 HU HU0202714A patent/HUP0202714A2/en unknown
- 2000-08-23 KR KR1020027002820A patent/KR20020040799A/en not_active Application Discontinuation
- 2000-08-23 CA CA002383517A patent/CA2383517A1/en not_active Abandoned
- 2000-08-23 EP EP00951784A patent/EP1210127A1/en not_active Withdrawn
- 2000-08-23 AU AU64631/00A patent/AU6463100A/en not_active Abandoned
- 2000-08-23 WO PCT/IB2000/001161 patent/WO2001015746A1/en not_active Application Discontinuation
- 2000-08-23 NZ NZ517377A patent/NZ517377A/en unknown
-
2002
- 2002-02-06 ZA ZA200201057A patent/ZA200201057B/en unknown
- 2002-02-26 BG BG06438A patent/BG106438A/en unknown
- 2002-02-28 NO NO20021001A patent/NO20021001L/en not_active Application Discontinuation
- 2002-08-30 HK HK02106423.2A patent/HK1044893A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2797769A1 (en) | 2001-03-02 |
| JP2003508455A (en) | 2003-03-04 |
| ZA200201057B (en) | 2003-07-30 |
| EA200200307A1 (en) | 2002-08-29 |
| EE200200105A (en) | 2003-04-15 |
| MXPA02001923A (en) | 2003-07-21 |
| BG106438A (en) | 2002-09-30 |
| NZ517377A (en) | 2003-08-29 |
| CA2383517A1 (en) | 2001-03-08 |
| AU6463100A (en) | 2001-03-26 |
| EP1210127A1 (en) | 2002-06-05 |
| IL148076A0 (en) | 2002-09-12 |
| WO2001015746A1 (en) | 2001-03-08 |
| NO20021001D0 (en) | 2002-02-28 |
| CN1371292A (en) | 2002-09-25 |
| YU14202A (en) | 2004-09-03 |
| HK1044893A1 (en) | 2002-11-08 |
| PL353803A1 (en) | 2003-12-01 |
| FR2797769B1 (en) | 2003-07-25 |
| BR0013729A (en) | 2002-05-07 |
| NO20021001L (en) | 2002-04-11 |
| KR20020040799A (en) | 2002-05-30 |
| CZ2002782A3 (en) | 2002-08-14 |
| SK2772002A3 (en) | 2002-09-10 |
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