HUP0202204A2 - Synergic pharmaceutical composition - Google Patents
Synergic pharmaceutical compositionInfo
- Publication number
- HUP0202204A2 HUP0202204A2 HU0202204A HUP0202204A HUP0202204A2 HU P0202204 A2 HUP0202204 A2 HU P0202204A2 HU 0202204 A HU0202204 A HU 0202204A HU P0202204 A HUP0202204 A HU P0202204A HU P0202204 A2 HUP0202204 A2 HU P0202204A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- alkoxy
- phenyl
- composition containing
- optionally
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 230000003178 anti-diabetic effect Effects 0.000 abstract 3
- 239000003472 antidiabetic agent Substances 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000003524 antilipemic agent Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- HPYLZSUEFFQHRS-UHFFFAOYSA-N 2h-1,2,4-oxadiazine Chemical compound N1OC=CN=C1 HPYLZSUEFFQHRS-UHFFFAOYSA-N 0.000 abstract 1
- YOGBMCNYVFIMJS-UHFFFAOYSA-N 5,6-dihydro-2h-1,2,4-oxadiazine Chemical compound C1CON=CN1 YOGBMCNYVFIMJS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- -1 biphenylyl Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Pharmaceutical combination, comprises: (A) a composition containing an antidiabetic or anti-hyperlipidemic agent (I); and (B) a composition containing a hydroximic acid derivative (II). Pharmaceutical combination, comprises: (A) a composition containing an antidiabetic or anti-hyperlipidemic agent (I); and (B) a composition containing a hydroximic acid derivative of formula (II). [Image] R 1>H or 1-5C alkyl; R 2>H, 1-5C alkyl, 3-8C cycloalkyl, phenyl, hydroxyphenyl or biphenylyl; R 3>H or a phenyl, naphthyl or pyridyl group (optionally substituted by halogen or 1-4C alkoxy); NR 1>R 2>5-8 membered ring (optionally containing further N, O or S heteroatoms and optionally fused to another alicyclic or heterocyclic ring, where N and/or S heteroatoms are optionally in oxide or dioxide form); Y : H, OH, 1-24C alkoxy (optionally substituted by amino), 2-24C polyalkenyloxy (with 1-6 double bonds), 1-25C alkanoyl, 3-9C alkenoyl or R 7>COO; R 7>2-24C polyalkenyl (with 1-6 double bonds); B : undefined; X : halo, amino or 1-4C alkoxy; or X+B : oxo; or X+Y : 1,2,4-oxadiazine or 4,5-dihydro-1,2,4-oxadiazine; R : H; A : 1-4C alkylene, a bond or (CHR 4>) m-(CHR 5>) n; R 4>H, 1-5C alkyl, 3-8C cycloalkyl or phenyl (optionally substituted by halo, 1-4C alkoxy or 1-5C alkyl); R 5>H, 1-4C alkyl or phenyl; and m, n : 0-2. ACTIVITY : Antidiabetic; Antilipemic. No biological data available. MECHANISM OF ACTION : None given.
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0202204A HU226244B1 (en) | 2002-07-05 | 2002-07-05 | Pharmaceutical combination for the prophylaxis or treatment of diabetes |
PT02751454T PT1408966E (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combinations for the prevention or treatment of diabetes |
AU2002354884A AU2002354884B2 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
ES02751454T ES2300460T3 (en) | 2001-07-17 | 2002-07-10 | PHARMACEUTICAL SYNERGIC COMBINATIONS INTENDED FOR THE PREVENTION OR TREATMENT OF DIABETES. |
JP2003513558A JP4598390B2 (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical composition for diabetes prevention or treatment |
UA2004021166A UA81608C2 (en) | 2002-07-05 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
KR1020047000748A KR100920560B1 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
DE60225143T DE60225143T2 (en) | 2001-07-17 | 2002-07-10 | SYNERGISTIC PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OR PROPHYLAXIS OF DIABETES |
MXPA04000324A MXPA04000324A (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes. |
BR0210744-9A BR0210744A (en) | 2001-07-17 | 2002-07-10 | Synergistically Pharmaceutical Combination for the Prevention or Treatment of Diabetes |
SI200230685T SI1408966T1 (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combinations for the prevention or treatment of diabetes |
AT02751454T ATE386523T1 (en) | 2001-07-17 | 2002-07-10 | SYNERGISTIC PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OR PROPHYLAXIS OF DIABETES |
PCT/HU2002/000067 WO2003007951A1 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
CA002452558A CA2452558C (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
IL15941202A IL159412A0 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
PL364662A PL205826B1 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
RU2004105149/15A RU2311907C2 (en) | 2001-07-17 | 2002-07-10 | Synergetic pharmaceutical composition for prophylaxis and treatment of diabetes mellitus |
US10/495,240 US7635674B2 (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combination for the prevention or treatment of diabetes |
CNB02814340XA CN1270713C (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combination for prevention or treatment of diabetes |
DK02751454T DK1408966T3 (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combinations for the prevention or treatment of diabetes |
EP02751454A EP1408966B1 (en) | 2001-07-17 | 2002-07-10 | Synergistic pharmaceutical combinations for the prevention or treatment of diabetes |
CA002682251A CA2682251A1 (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
NZ531155A NZ531155A (en) | 2001-07-17 | 2002-07-10 | A synergistic pharmaceutical combination for the prevention or treatment of diabetes |
IL159412A IL159412A (en) | 2001-07-17 | 2003-12-17 | Synergistic pharmaceutical combination for the prevention or treatment of diabetes |
NO20040153A NO20040153L (en) | 2001-07-17 | 2004-01-13 | Synergistic pharmaceutical combination for prophylaxis or treatment of diabetes |
CY20081100487T CY1107939T1 (en) | 2001-07-17 | 2008-05-08 | SYNOPTIC MEDICINAL DRUGS FOR PREVENTION OR TREATMENT OF DIABETES |
US12/614,225 US8048873B2 (en) | 2001-07-17 | 2009-11-06 | Synergistic pharmaceutical combination for the prevention or treatment of diabetes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0202204A HU226244B1 (en) | 2002-07-05 | 2002-07-05 | Pharmaceutical combination for the prophylaxis or treatment of diabetes |
Publications (3)
Publication Number | Publication Date |
---|---|
HU0202204D0 HU0202204D0 (en) | 2002-09-28 |
HUP0202204A2 true HUP0202204A2 (en) | 2003-05-28 |
HU226244B1 HU226244B1 (en) | 2008-07-28 |
Family
ID=89980598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0202204A HU226244B1 (en) | 2001-07-17 | 2002-07-05 | Pharmaceutical combination for the prophylaxis or treatment of diabetes |
Country Status (2)
Country | Link |
---|---|
HU (1) | HU226244B1 (en) |
UA (1) | UA81608C2 (en) |
-
2002
- 2002-07-05 HU HU0202204A patent/HU226244B1/en not_active IP Right Cessation
- 2002-07-10 UA UA2004021166A patent/UA81608C2/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU0202204D0 (en) | 2002-09-28 |
UA81608C2 (en) | 2008-01-25 |
HU226244B1 (en) | 2008-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NF4A | Restoration of patent protection | ||
MM4A | Lapse of definitive patent protection due to non-payment of fees |