HUP0104977A2 - (E)-7-[4-(4-fluor-fenil)-6-izopropil-2-(metil-/metilszulfonil/-amino)-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-6-hepténkarbonsavat és egy P450 3A4 izoenzim-inhibítort, -indukálószert vagy szubsztrátumot tartalmazó gyógyszerkombináció - Google Patents

(E)-7-[4-(4-fluor-fenil)-6-izopropil-2-(metil-/metilszulfonil/-amino)-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-6-hepténkarbonsavat és egy P450 3A4 izoenzim-inhibítort, -indukálószert vagy szubsztrátumot tartalmazó gyógyszerkombináció

Info

Publication number
HUP0104977A2
HUP0104977A2 HU0104977A HUP0104977A HUP0104977A2 HU P0104977 A2 HUP0104977 A2 HU P0104977A2 HU 0104977 A HU0104977 A HU 0104977A HU P0104977 A HUP0104977 A HU P0104977A HU P0104977 A2 HUP0104977 A2 HU P0104977A2
Authority
HU
Hungary
Prior art keywords
inhibitor
isoenzyme
inducer
substrate
dihydroxyhept
Prior art date
Application number
HU0104977A
Other languages
English (en)
Inventor
Takahiko Baba
Howard Gerard Hutchinson
John Stuart Pears
Ali Raza
Dennis Schneck
Akira Touchi
Yoshitaka Yamaguchi
Original Assignee
Astrazeneca Ab,
Shionogi & Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39325657&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0104977(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9902593.4A external-priority patent/GB9902593D0/en
Priority claimed from GBGB9921064.3A external-priority patent/GB9921064D0/en
Priority claimed from GBGB9921063.5A external-priority patent/GB9921063D0/en
Application filed by Astrazeneca Ab,, Shionogi & Co. Ltd. filed Critical Astrazeneca Ab,
Priority claimed from PCT/GB2000/000278 external-priority patent/WO2000045817A1/en
Publication of HUP0104977A2 publication Critical patent/HUP0104977A2/hu
Publication of HUP0104977A3 publication Critical patent/HUP0104977A3/hu
Publication of HU226062B1 publication Critical patent/HU226062B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány tárgya nem interaktív gyógyszerkombináció, amely egy HMG-CoA reduktáz inhibítort, éspedig (E)-7-[4-(4-fluor-fenil)-6-izopropil-2-(metil-/metilszulfonil/-amino)-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-6-hepténkarbonsavat vagy gyógyászatilag alkalmazható sójáttartalmazza, és egy olyan gyógyszert tartalmaz, ami a P450 3A4izoenzim inhibítora, indukálószere vagy szubsztrátuma. A találmányszerinti gyógyszerkombináció a két gyógyszert együtt vagy egymástkövetően adagolhatóan tartalmazza. A találmány szerintigyógyszerkombinációt hiperlipidémia kezelésére használható. Ó
HU0104977A 1999-02-06 2000-02-01 Drug combinations comprising (e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl-(methylsulfonyl)-amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4 HU226062B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9902593.4A GB9902593D0 (en) 1999-02-06 1999-02-06 Drug combinations
GBGB9921064.3A GB9921064D0 (en) 1999-09-08 1999-09-08 Drug combination
GBGB9921063.5A GB9921063D0 (en) 1999-09-08 1999-09-08 Therapy
PCT/GB2000/000278 WO2000045817A1 (en) 1999-02-06 2000-02-01 Drug combinations comprising (e) -7 - [4 -(4 -fluorophenyl) -6 - isopropyl -2 - [methyl (methylsulfonyl) amino] pyrimidin -5 -yl] (3r,5s) -3,5 - dihydroxyhept -6 - enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4

Publications (3)

Publication Number Publication Date
HUP0104977A2 true HUP0104977A2 (hu) 2002-05-29
HUP0104977A3 HUP0104977A3 (en) 2006-07-28
HU226062B1 HU226062B1 (en) 2008-04-28

Family

ID=39325657

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104977A HU226062B1 (en) 1999-02-06 2000-02-01 Drug combinations comprising (e)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl-(methylsulfonyl)-amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4

Country Status (1)

Country Link
HU (1) HU226062B1 (hu)

Also Published As

Publication number Publication date
HU226062B1 (en) 2008-04-28
HUP0104977A3 (en) 2006-07-28

Similar Documents

Publication Publication Date Title
AP1879A (en) Pharmaceutical compositions comprising a HMG CoA reductase inhibitor.
DK1897546T3 (da) Kombinerede sammensætninger omfattende (E)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r,5s]-3,5-dihydroxyhept-6-enoinsyre
MY142615A (en) Crystalline form of bis [ (e)-7-4(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3r, 5s)-3,5-dihydroxyhept-6 -enoic acid] calcium salt
CA2429263A1 (en) Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia
DK1682536T3 (da) Fremgangsmåde til fremstilling af calciumsaltet af rosuvastatin (e)-7-[4-(4-fluorphenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-ensyre og krystallinske mellemprodukter deraf
MY129018A (en) Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]-(3r,5s)-3,5-dihydroxyhept-6-enoic acid
NO20013811L (no) Medikament-kombinasjoner omfattende (E)-7-[4-(4-fluorfenyl)-6- isopropyl-2-[metyl-(metylsulfonyl)-amino]-pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksy-hept-6-ensyre og en inhibitor, inducer ellersubstrat av P450 isoenzym 3A4
HUP0104828A2 (hu) Kristályos bisz[ (E)-7-[4-(4-fluor-fenil)-6-izopropil-2-[metil-(metilszulfonil)-amino]-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-6-hepténsav]-kalciumsó, ezt tartalmazó készítmény és eljárás az előállításukra
HUP0104977A2 (hu) (E)-7-[4-(4-fluor-fenil)-6-izopropil-2-(metil-/metilszulfonil/-amino)-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-6-hepténkarbonsavat és egy P450 3A4 izoenzim-inhibítort, -indukálószert vagy szubsztrátumot tartalmazó gyógyszerkombináció
PL1704144T3 (pl) Sposób wytwarzania soli wapniowej kwasu (E)-7-[4-(4-fluorofenylo)-6-izopropylo-2-[metylo(metylosulfonylo)amino]pirymidyn-5-ylo](3R,5S)-3,5-dihydroksy-6-heptenowego
SI1185274T1 (en) Drug combinations comprising (e)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(methylsulfonyl)amino)pyrimidin-5-yl)(3r,5s)-3,5-dihydroxyhept-6-enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4
DK1185274T3 (da) Lægemiddelkombinationer omfattende (E) - 7 -[4- (4-fluorphenyl) - 6 - isopropyl-2 [methyl(methylsulfonyl)amino ]-pyrimidin-5-yl] (3R,5S) - 3,5-dihydroxyhept-6-ensyre og en inhibitor af, en inducer af eller et substrat for P450 isoenzym 3A4
UY30336A1 (es) Composiciones farmacéuticas conteniendo ácido (e)-7-(4-(4-fluorofenil)-6-isopropil-2-(metil(metilsulfonil)amino)pirimidin-5-il)-(3r,5s)-3,5-dihidroxihept-6-enoico y sales farmacéuticamente aceptables de la misma