HUP0104853A2 - New transdermal anti-inflammatory medicine containing liposomic niflumic acid - Google Patents

New transdermal anti-inflammatory medicine containing liposomic niflumic acid

Info

Publication number
HUP0104853A2
HUP0104853A2 HU0104853A HUP0104853A HUP0104853A2 HU P0104853 A2 HUP0104853 A2 HU P0104853A2 HU 0104853 A HU0104853 A HU 0104853A HU P0104853 A HUP0104853 A HU P0104853A HU P0104853 A2 HUP0104853 A2 HU P0104853A2
Authority
HU
Hungary
Prior art keywords
niflumic acid
liposomic
medicine containing
new transdermal
inflammatory medicine
Prior art date
Application number
HU0104853A
Other languages
Hungarian (hu)
Inventor
Konstantinos Demetzos
Aristidis Georgopoulos
Georgios Giannisis
Sofia Hatziantoniou
Helen Kammenou
Georgios Nounesis
Georgios Papaioannou
Michalis Rallis
Christina Savva-Dimopoulou
Georgios Tsamouris
Original Assignee
P.N. Gerolymatos S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by P.N. Gerolymatos S.A. filed Critical P.N. Gerolymatos S.A.
Publication of HUP0104853A2 publication Critical patent/HUP0104853A2/en
Publication of HUP0104853A3 publication Critical patent/HUP0104853A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

Jelen találmány nifluminsav és származékainak, szintetikus észtereinekliposzómákba való bekapszulázására vonatkozik abból a célból, hogy egyúj transzdermális, nem szteroid gyulladásgátló készítményt hozzanaklétre. A nifluminsavat és ennek észtereit különböző lipidekbőlkészített liposzómákba kapszulázták be, hogy egy növelt hatékonyságúgyógyszerkészítményt kapjanak. A liposzóma-szuszpenziót önmagában éshatóanyaggal töltötten egyaránt előállították kenőcsformában, és avégső összetétellel stabilitásvizsgálatot végeznek. ÓThe present invention relates to the encapsulation of niflumic acid and its derivatives, synthetic esters, in liposomes with the aim of creating a new transdermal, non-steroidal anti-inflammatory preparation. Niflumic acid and its esters were encapsulated in liposomes made of different lipids to obtain a drug preparation with increased efficacy. The liposome suspension was produced both alone and filled with an active ingredient in ointment form, and a stability test is performed with the final composition. HE

HU0104853A 1998-12-24 1999-12-22 New transdermal anti-inflammatory medicine containing liposomic niflumic acid HUP0104853A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR98100469 1998-12-24

Publications (2)

Publication Number Publication Date
HUP0104853A2 true HUP0104853A2 (en) 2002-05-29
HUP0104853A3 HUP0104853A3 (en) 2003-05-28

Family

ID=10943556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104853A HUP0104853A3 (en) 1998-12-24 1999-12-22 New transdermal anti-inflammatory medicine containing liposomic niflumic acid

Country Status (17)

Country Link
EP (1) EP1140089A1 (en)
JP (1) JP2002533394A (en)
KR (1) KR20010089889A (en)
CN (1) CN1331592A (en)
AU (1) AU1673400A (en)
BR (1) BR9917006A (en)
CA (1) CA2357765A1 (en)
CZ (1) CZ20012240A3 (en)
GR (1) GR1003359B (en)
HU (1) HUP0104853A3 (en)
IL (1) IL143499A0 (en)
IS (1) IS5964A (en)
MX (1) MXPA01006462A (en)
NO (1) NO20013015D0 (en)
PL (1) PL349344A1 (en)
SK (1) SK7962001A3 (en)
WO (1) WO2000038681A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
KR20060015534A (en) * 2003-04-25 2006-02-17 더 펜 스테이트 리서치 파운데이션 Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
JP4791082B2 (en) * 2005-05-30 2011-10-12 株式会社クラレ Liposomes and topical skin preparations containing the same
JP4931369B2 (en) * 2005-05-31 2012-05-16 ポーラ化成工業株式会社 Liposomes and therapeutic compositions containing the same
PL1888033T3 (en) 2005-06-09 2014-09-30 Meda Ab Method and composition for treating inflammatory disorders
BR112013003658B1 (en) 2010-07-28 2022-02-22 Life Technologies Corporation Pharmaceutical composition comprising azide-modified isoprenoid fatty acid, carbohydrate and lipid, use of such components and method of inhibiting infectivity of a virus
US20120028335A1 (en) 2010-07-28 2012-02-02 Life Technologies Corporation Anti-viral azide-containing compounds
AU2013212068B2 (en) 2012-01-26 2018-02-15 Life Technologies Corporation Methods for increasing the infectivity of viruses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528193A (en) * 1978-12-27 1985-07-09 A. Natterman & Cie. Gmbh Inflammation-preventing pharmaceutical composition of oral administration
EP0225162B1 (en) * 1985-11-27 1992-01-22 Ethicon, Inc. Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug
EP0249561B1 (en) * 1986-06-12 1992-05-13 The Liposome Company, Inc. Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs
EP0825852B1 (en) * 1995-04-18 2004-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition

Also Published As

Publication number Publication date
KR20010089889A (en) 2001-10-12
MXPA01006462A (en) 2002-06-04
HUP0104853A3 (en) 2003-05-28
NO20013015L (en) 2001-06-18
JP2002533394A (en) 2002-10-08
EP1140089A1 (en) 2001-10-10
CZ20012240A3 (en) 2001-11-14
IL143499A0 (en) 2002-04-21
NO20013015D0 (en) 2001-06-18
WO2000038681A1 (en) 2000-07-06
CA2357765A1 (en) 2000-07-06
GR1003359B (en) 2000-04-10
IS5964A (en) 2001-06-08
BR9917006A (en) 2001-10-30
AU1673400A (en) 2000-07-31
CN1331592A (en) 2002-01-16
SK7962001A3 (en) 2002-02-05
PL349344A1 (en) 2002-07-15

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