HUP0103502A2 - Streptococcal c betha protein compositions - Google Patents
Streptococcal c betha protein compositionsInfo
- Publication number
- HUP0103502A2 HUP0103502A2 HU0103502A HUP0103502A HUP0103502A2 HU P0103502 A2 HUP0103502 A2 HU P0103502A2 HU 0103502 A HU0103502 A HU 0103502A HU P0103502 A HUP0103502 A HU P0103502A HU P0103502 A2 HUP0103502 A2 HU P0103502A2
- Authority
- HU
- Hungary
- Prior art keywords
- subject
- protein fragments
- peptides
- trigger
- animal
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 4
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000192125 Firmicutes Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000004154 complement system Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000000625 opsonophagocytic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Abstract
A jelen találmány tárgyát olyan fehérje-fragmensek vagy peptidekképezik, amelyek olyan ellenanyagok termelődését váltják ki, amelyekpusztán a komplemetrendszerrel együtt (azaz az aktivitás nem opszono-fagocita mechanizmustól függ) baktériumölő hatást fejtenek ki a Gram-pozitív baktériumokra, a találmány tárgyát képezik még az ezekettartalmazó oltóanyagok és konjugátumok is. A fehérje-fragmensek vagy apeptidek egy immunogén, IgG-kötő domént tartalmaznak. A találmánytárgyát képezi rnég egy, a fehérje-fragmenseket vagy peptideket kódolópolinukleotid-molekula is, továbbá a találmány tárgyát képezik még azilyen polinukleotid-molekulákat hordozó vektorok, valamint az ezekkeltranszformált gazdasejtek is. A találmány tárgyát képezi még alényegében tiszta Cb-fehérje vagy annak fragmensének és/vagymutánsának előállítására szolgáló eljárás is. A találmány tárgyátképezi továbbá egy olyan eljárás is, amely egy immunválasz kiváltásáraszolgál egy állatban, amely eljárás abból áll, hogy az állatba atalálmány szerinti oltóanyag-készítményt, amely egy gyógyszerészetilegelfogadható hordozóanyagot is tartalmaz, terápiásan hatékonymennyiségben adják be. ÓThe subject of the present invention is protein fragments or peptides that trigger the production of antibodies that, together with the complement system alone (i.e. the activity does not depend on the opsono-phagocytic mechanism) have a bactericidal effect on Gram-positive bacteria, the subject of the invention is also the products containing these also vaccines and conjugates. Protein fragments or apeptides contain an immunogenic, IgG-binding domain. The subject of the invention is also a polynucleotide molecule encoding protein fragments or peptides, and the subject of the invention is also the vectors carrying such polynucleotide molecules, as well as the host cells transformed with them. The subject of the invention is also a method for producing a substantially pure Cb protein or its fragment and/or mutant. The invention also covers a method that serves to trigger an immune response in an animal, which method consists in administering a therapeutically effective amount of the vaccine composition according to the invention, which also contains a pharmaceutically acceptable carrier, to the animal. HE
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10085998P | 1998-09-17 | 1998-09-17 | |
| US14432499P | 1999-07-19 | 1999-07-19 | |
| US15401799P | 1999-09-15 | 1999-09-15 | |
| PCT/US1999/021643 WO2000015760A1 (en) | 1998-09-17 | 1999-09-17 | Streptococcal c beta protein compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0103502A2 true HUP0103502A2 (en) | 2002-01-28 |
Family
ID=27379089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103502A HUP0103502A2 (en) | 1998-09-17 | 1999-09-17 | Streptococcal c betha protein compositions |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1114143A4 (en) |
| JP (1) | JP2002525041A (en) |
| AU (1) | AU6049599A (en) |
| CA (1) | CA2343051A1 (en) |
| CZ (1) | CZ2001951A3 (en) |
| HU (1) | HUP0103502A2 (en) |
| NO (1) | NO20011381D0 (en) |
| PL (1) | PL347058A1 (en) |
| SK (1) | SK3482001A3 (en) |
| WO (1) | WO2000015760A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899700A0 (en) | 2000-07-25 | 2000-08-17 | Borody, Thomas Julius | Probiotic recolonisation therapy |
| EP3311825A1 (en) | 2010-08-04 | 2018-04-25 | Thomas Julius Borody | Compositions for fecal floral transplantation and methods for making and using them |
| WO2012122478A1 (en) | 2011-03-09 | 2012-09-13 | Regents Of The University Of Minnesota | Compositions and methods for transplantation of colon microbiota |
| EP2836224A4 (en) | 2012-02-29 | 2015-12-16 | Ethicon Endo Surgery Inc | Compositions of microbiota and methods related thereto |
| WO2013176774A1 (en) | 2012-05-25 | 2013-11-28 | Arizona Board Of Regents | Microbiome markers and therapies for autism spectrum disorders |
| JP6868562B2 (en) | 2014-10-31 | 2021-05-19 | ペンデュラム セラピューティクス， インコーポレイテッド | Methods and compositions for microbial treatment and diagnosis of disorders |
| KR102561989B1 (en) | 2015-05-14 | 2023-07-31 | 핀치 테라퓨틱스 홀딩스 엘엘씨 | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| PL3297644T3 (en) | 2015-05-22 | 2022-05-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| US20170360848A1 (en) | 2016-06-15 | 2017-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| US10849936B2 (en) | 2016-07-01 | 2020-12-01 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
| US20180036352A1 (en) | 2016-08-03 | 2018-02-08 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
| WO2018071537A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| WO2018071536A1 (en) | 2016-10-11 | 2018-04-19 | Crestovo Holdings Llc | Compositions and methods for treating primary sclerosing cholangitis and related disorders |
| US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| AU2018250206A1 (en) | 2017-04-05 | 2019-10-31 | Crestovo Holdings Llc | Compositions and methods for treating parkinson's disease (PD) and related disorders |
| US11040073B2 (en) | 2017-04-05 | 2021-06-22 | Finch Therapeutics Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
| CA3064773A1 (en) | 2017-05-26 | 2018-11-29 | Crestovo Holdings Llc | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
| EP3664823A4 (en) | 2017-08-07 | 2021-05-12 | Finch Therapeutics, Inc. | Compositions and methods for maintaining and restoring a healthy gut barrier |
| CN111372596A (en) | 2017-08-30 | 2020-07-03 | 潘德勒姆治疗公司 | Methods and compositions for treating microbiome-related disorders |
| US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
| CN113164527A (en) | 2018-09-27 | 2021-07-23 | 芬奇治疗控股有限责任公司 | Compositions and methods for treating epilepsy and related disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757134A (en) * | 1982-12-02 | 1988-07-12 | The Rockefeller University | IgA binding protein |
| US5595740A (en) * | 1994-05-16 | 1997-01-21 | University Of Florida | Cloning of non-IgA FC binding forms of the group B streptococcal beta antigens |
| PL185701B1 (en) * | 1996-09-06 | 2003-07-31 | Baxter Healthcare Sa | Beta forms of b-group streptococci antigens unable to become assimilated with iga fc |
-
1999
- 1999-09-17 AU AU60495/99A patent/AU6049599A/en not_active Abandoned
- 1999-09-17 HU HU0103502A patent/HUP0103502A2/en unknown
- 1999-09-17 WO PCT/US1999/021643 patent/WO2000015760A1/en not_active Application Discontinuation
- 1999-09-17 JP JP2000570287A patent/JP2002525041A/en not_active Withdrawn
- 1999-09-17 PL PL99347058A patent/PL347058A1/en not_active Application Discontinuation
- 1999-09-17 EP EP99969108A patent/EP1114143A4/en not_active Withdrawn
- 1999-09-17 CZ CZ2001951A patent/CZ2001951A3/en unknown
- 1999-09-17 SK SK348-2001A patent/SK3482001A3/en unknown
- 1999-09-17 CA CA002343051A patent/CA2343051A1/en not_active Abandoned
-
2001
- 2001-03-19 NO NO20011381A patent/NO20011381D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK3482001A3 (en) | 2002-02-05 |
| CA2343051A1 (en) | 2000-03-23 |
| CZ2001951A3 (en) | 2001-11-14 |
| NO20011381L (en) | 2001-03-19 |
| EP1114143A4 (en) | 2003-05-07 |
| JP2002525041A (en) | 2002-08-13 |
| AU6049599A (en) | 2000-04-03 |
| NO20011381D0 (en) | 2001-03-19 |
| PL347058A1 (en) | 2002-03-11 |
| WO2000015760A1 (en) | 2000-03-23 |
| EP1114143A1 (en) | 2001-07-11 |
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