HUP0102455A2 - Novel nucleic acid transfer agents, compositions containing same and uses - Google Patents

Novel nucleic acid transfer agents, compositions containing same and uses

Info

Publication number
HUP0102455A2
HUP0102455A2 HU0102455A HUP0102455A HUP0102455A2 HU P0102455 A2 HUP0102455 A2 HU P0102455A2 HU 0102455 A HU0102455 A HU 0102455A HU P0102455 A HUP0102455 A HU P0102455A HU P0102455 A2 HUP0102455 A2 HU P0102455A2
Authority
HU
Hungary
Prior art keywords
nucleic acid
transfer agents
acid transfer
compositions containing
containing same
Prior art date
Application number
HU0102455A
Other languages
Hungarian (hu)
Inventor
Gerardo Byk
Marc Frederic
Hans Hofland
Daniel Schermann
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9804121A external-priority patent/FR2777017B1/en
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of HUP0102455A2 publication Critical patent/HUP0102455A2/en
Publication of HUP0102455A3 publication Critical patent/HUP0102455A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgyát sejtekben nukleinsav-transzfer ágenskéntalkalmazható új vegyületek képezik. Ezek az új vegyületekrészletesebben meghatározva a lipopoliaminok családjába tartoznak, éslegalább egy ciklikus amidin csoportot hozdoznak. Alkalmazhatóaknuklensavak különböző sejttípusokba történő transzfekciójára in vitro,ex vivo és in vivo egyaránt. ÓThe subject of the invention are new compounds that can be used as nucleic acid transfer agents in cells. More precisely, these new compounds belong to the family of lipopolyamines and bear at least one cyclic amidine group. They can be used for the transfection of nucleic acids into different cell types in vitro, ex vivo and in vivo. HE

HU0102455A 1998-04-02 1999-03-30 Novel nucleic acid transfer agents, compositions containing same and uses HUP0102455A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9804121A FR2777017B1 (en) 1998-04-02 1998-04-02 NOVEL NUCLEIC ACID TRANSFER AGENTS, COMPOSITIONS CONTAINING THEM AND USES THEREOF
US8584598P 1998-05-18 1998-05-18
PCT/FR1999/000740 WO1999051581A1 (en) 1998-04-02 1999-03-30 Novel nucleic acid transfer agents, compositions containing same and uses

Publications (2)

Publication Number Publication Date
HUP0102455A2 true HUP0102455A2 (en) 2001-10-28
HUP0102455A3 HUP0102455A3 (en) 2003-09-29

Family

ID=26234240

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102455A HUP0102455A3 (en) 1998-04-02 1999-03-30 Novel nucleic acid transfer agents, compositions containing same and uses

Country Status (12)

Country Link
EP (1) EP1068188A1 (en)
JP (1) JP2002513543A (en)
KR (1) KR20010042318A (en)
CN (1) CN1294582A (en)
AU (1) AU759301B2 (en)
BR (1) BR9909350A (en)
CA (1) CA2324931A1 (en)
HU (1) HUP0102455A3 (en)
IL (1) IL138625A0 (en)
NO (1) NO317225B1 (en)
PL (1) PL342886A1 (en)
WO (1) WO1999051581A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
ITMI20050222A1 (en) * 2005-02-15 2006-08-16 Milano Politecnico CATION LIPIDS FOR THE TRANSFORMATION OF NUCLEIC ACIDS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2645866B1 (en) * 1989-04-17 1991-07-05 Centre Nat Rech Scient NEW LIPOPOLYAMINES, THEIR PREPARATION AND THEIR USE
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
FR2714830B1 (en) * 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
FR2727679B1 (en) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa NEW TRANSFECTION AGENTS AND THEIR PHARMACEUTICAL APPLICATIONS
FR2741066B1 (en) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa NEW TRANSFECTION AGENTS AND THEIR PHARMACEUTICAL APPLICATIONS
AU723998B2 (en) * 1996-03-01 2000-09-07 Centre National De La Recherche Scientifique Compounds related to the amidinium family, pharmaceutical compositions containing same, and uses thereof

Also Published As

Publication number Publication date
PL342886A1 (en) 2001-07-16
CA2324931A1 (en) 1999-10-14
EP1068188A1 (en) 2001-01-17
NO317225B1 (en) 2004-09-20
HUP0102455A3 (en) 2003-09-29
AU3406100A (en) 2000-11-30
WO1999051581A1 (en) 1999-10-14
CN1294582A (en) 2001-05-09
NO20004780D0 (en) 2000-09-25
JP2002513543A (en) 2002-05-14
BR9909350A (en) 2000-12-12
AU759301B2 (en) 2003-04-10
NO20004780L (en) 2000-11-01
KR20010042318A (en) 2001-05-25
IL138625A0 (en) 2001-10-31

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