HUP0101713A2 - Process for the preparation of artificial blood - Google Patents

Process for the preparation of artificial blood

Info

Publication number
HUP0101713A2
HUP0101713A2 HU0101713A HUP0101713A HUP0101713A2 HU P0101713 A2 HUP0101713 A2 HU P0101713A2 HU 0101713 A HU0101713 A HU 0101713A HU P0101713 A HUP0101713 A HU P0101713A HU P0101713 A2 HUP0101713 A2 HU P0101713A2
Authority
HU
Hungary
Prior art keywords
blood
artificial blood
preparation
hemoglobin
species
Prior art date
Application number
HU0101713A
Other languages
Hungarian (hu)
Inventor
István Horváth
Original Assignee
István Horváth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by István Horváth filed Critical István Horváth
Priority to HU0101713A priority Critical patent/HUP0101713A2/en
Publication of HU0101713D0 publication Critical patent/HU0101713D0/en
Priority to PCT/HU2002/000030 priority patent/WO2002087540A1/en
Publication of HUP0101713A2 publication Critical patent/HUP0101713A2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Abstract

A találmány tárgya olyan mesterséges vér előállítása, amely alkalmasbármilyen vércsoportú kivérzett szervezetben a vér átmeneti pótlására.Az eljárás alkalmas haemoglobinból és a gerincesek szervezetébenelőforduló lipoidok felhasználásával művérként felhasználhatóliposomák előállítására. A természetes vérsejteknél kisebb méretű(200-500 nm) partikulák alkalmasak a vörösvérsejtek gázszállítófunkciójának helyettesítésére. A művér partikulák előállításafajspecifikus vagy a fajtól eltérő eredetű haemoglobinfelhasználásával történhet. ÓThe subject of the invention is the production of artificial blood that is suitable for the temporary replacement of blood in a bleeding body of any blood type. The process is suitable for the production of liposomes that can be used as artificial blood using hemoglobin and lipoids that occur in the body of vertebrates. Particles smaller than natural blood cells (200-500 nm) are suitable for replacing the gas transport function of red blood cells. Artificial blood particles can be produced using species-specific or non-species hemoglobin. HE

HU0101713A 2001-04-27 2001-04-27 Process for the preparation of artificial blood HUP0101713A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU0101713A HUP0101713A2 (en) 2001-04-27 2001-04-27 Process for the preparation of artificial blood
PCT/HU2002/000030 WO2002087540A1 (en) 2001-04-27 2002-04-10 Artificial blood made of hemoglobin encapsulated in liposomes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0101713A HUP0101713A2 (en) 2001-04-27 2001-04-27 Process for the preparation of artificial blood

Publications (2)

Publication Number Publication Date
HU0101713D0 HU0101713D0 (en) 2001-07-30
HUP0101713A2 true HUP0101713A2 (en) 2003-02-28

Family

ID=89979242

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101713A HUP0101713A2 (en) 2001-04-27 2001-04-27 Process for the preparation of artificial blood

Country Status (2)

Country Link
HU (1) HUP0101713A2 (en)
WO (1) WO2002087540A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226519B1 (en) * 2002-11-26 2009-03-30 Istvan Dr Horvath Artificial blood made of hemoglobin encapsulated in membrane
CA3078625C (en) 2017-10-09 2023-01-17 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
WO2020185909A2 (en) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
EP0082877A1 (en) * 1981-07-06 1983-07-06 Rush-Presbyterian-St.Luke's Medical Center Preparation of synthetic erythrocytes
US4532130A (en) * 1981-07-06 1985-07-30 Rush-Presbyterian-St. Luke's Medical Center Preparation of synthetic frythrocytes
US4911929A (en) * 1986-08-29 1990-03-27 The United States Of America As Represented By The Secretary Of The Navy Blood substitute comprising liposome-encapsulated hemoglobin
JPS6475418A (en) * 1987-09-14 1989-03-22 Terumo Corp Production of liposome
JP2000051322A (en) * 1998-08-12 2000-02-22 Terumo Corp Processing method for hemoglobin solution, artificial blood and manufacture of artificial blood

Also Published As

Publication number Publication date
WO2002087540A1 (en) 2002-11-07
HU0101713D0 (en) 2001-07-30

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