HUP0004857A2 - D-amino acid oxidase promoter from t. variabilis - Google Patents

D-amino acid oxidase promoter from t. variabilis

Info

Publication number
HUP0004857A2
HUP0004857A2 HU0004857A HUP0004857A HUP0004857A2 HU P0004857 A2 HUP0004857 A2 HU P0004857A2 HU 0004857 A HU0004857 A HU 0004857A HU P0004857 A HUP0004857 A HU P0004857A HU P0004857 A2 HUP0004857 A2 HU P0004857A2
Authority
HU
Hungary
Prior art keywords
promoter
variabilis
amino acid
acid oxidase
expression
Prior art date
Application number
HU0004857A
Other languages
Hungarian (hu)
Inventor
Thomas Franceschini
Suo W. Liu
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0004857A2 publication Critical patent/HUP0004857A2/en
Publication of HUP0004857A3 publication Critical patent/HUP0004857A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)

Abstract

A találmány tárgya T. variabilisből származó D-aminosav oxidáz génpromoterrégióját tartalmazó, izolált nukleinsav. Meghatározták apromoter szekvenciáját. A találmány tárgyát képezik olyan expressziós vektorok is, amelyeka találmány szerinti promotert tartalmazzák, különösen olyan vektorok,amelyek S. cerevisiaeben való expresszióra alkalmasak. A találmányszerinti előnyös expressziós vektorok az új promoterrel rendelkeznekS. cerevisiae szelektálható markertől szintézisiránnyal szembenelhelyezve. A vektor manipulálása ugyanezen, a promotert tartalmazóvetkorba klónozott, kívánt fehérje fokozott expressziójához vezet. ÓThe subject of the invention is an isolated nucleic acid containing the D-amino acid oxidase gene promoter region from T. variabilis. The apromoter sequence was determined. The invention also covers expression vectors that contain the promoter according to the invention, especially vectors that are suitable for expression in S. cerevisiae. The preferred expression vectors of the invention have the novel promoter S. cerevisiae upstream of the selectable marker. Manipulation of the vector leads to increased expression of the desired protein cloned into the same promoter-containing vector. HE

HU0004857A 1997-06-25 1998-06-08 D-amino acid oxidase promoter from t. variabilis HUP0004857A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5074097P 1997-06-25 1997-06-25
PCT/US1998/011759 WO1998059037A1 (en) 1997-06-25 1998-06-08 D-amino acid oxidase promoter from t. variabilis

Publications (2)

Publication Number Publication Date
HUP0004857A2 true HUP0004857A2 (en) 2001-04-28
HUP0004857A3 HUP0004857A3 (en) 2001-09-28

Family

ID=21967122

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004857A HUP0004857A3 (en) 1997-06-25 1998-06-08 D-amino acid oxidase promoter from t. variabilis

Country Status (8)

Country Link
US (1) US6025159A (en)
EP (1) EP0990023A4 (en)
JP (1) JP2002505587A (en)
AU (1) AU749453B2 (en)
CA (1) CA2292844A1 (en)
HU (1) HUP0004857A3 (en)
IL (2) IL133259A0 (en)
WO (1) WO1998059037A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4830079B2 (en) * 2000-11-29 2011-12-07 国立感染症研究所長 Method for measuring protease activity
US7187286B2 (en) 2004-03-19 2007-03-06 Applera Corporation Methods and systems for using RFID in biological field
EP2235198B1 (en) * 2007-12-19 2018-08-29 GlycoFi, Inc. Yeast strains for protein production
EP3277822B1 (en) * 2015-04-03 2020-05-06 Temasek Life Sciences Laboratory Limited D-amino acid-inducible gene expression system for rhodosporidium and rhodotorula
US11112416B2 (en) 2018-01-30 2021-09-07 Life Technologies Corporation Instruments, devices and consumables for use in a workflow of a smart molecular analysis system

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE123303T1 (en) * 1988-10-13 1995-06-15 Fujisawa Pharmaceutical Co D-AMINO ACID OXIDASE.
KR0173124B1 (en) * 1989-04-04 1999-02-01 카알 더블유. 라우쉬 Enzymatic production of 7-amino cephalosporanic acid
DE4133038A1 (en) * 1991-10-07 1993-04-08 Genentech Inc NEW RECOMBINANT VIRUSES, THEIR USE AND THEIR PRODUCTION
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase

Also Published As

Publication number Publication date
HUP0004857A3 (en) 2001-09-28
IL133259A0 (en) 2001-04-30
AU7823598A (en) 1999-01-04
EP0990023A4 (en) 2001-04-18
US6025159A (en) 2000-02-15
AU749453B2 (en) 2002-06-27
JP2002505587A (en) 2002-02-19
IL133259A (en) 2006-06-11
CA2292844A1 (en) 1998-12-30
WO1998059037A1 (en) 1998-12-30
EP0990023A1 (en) 2000-04-05

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Legal Events

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