HUP0004498A2 - Method for preparing biocompatible scaffold and scaffold prepared there form - Google Patents

Method for preparing biocompatible scaffold and scaffold prepared there form

Info

Publication number
HUP0004498A2
HUP0004498A2 HU0004498A HUP0004498A HUP0004498A2 HU P0004498 A2 HUP0004498 A2 HU P0004498A2 HU 0004498 A HU0004498 A HU 0004498A HU P0004498 A HUP0004498 A HU P0004498A HU P0004498 A2 HUP0004498 A2 HU P0004498A2
Authority
HU
Hungary
Prior art keywords
polymer
salt
organic solvent
gel
scaffold
Prior art date
Application number
HU0004498A
Other languages
Hungarian (hu)
Inventor
Tae-Gwan Park
Jun-Jin Yoon
Original Assignee
Korea Advanced Institute Of Science And Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Advanced Institute Of Science And Technology filed Critical Korea Advanced Institute Of Science And Technology
Publication of HU0004498D0 publication Critical patent/HU0004498D0/hu
Publication of HUP0004498A2 publication Critical patent/HUP0004498A2/en
Publication of HUP0004498A3 publication Critical patent/HUP0004498A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0014—Use of organic additives
    • C08J9/0023—Use of organic additives containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

A találmány háromdimenziós, biológiai úton lebontható és biológiailagkompatibilis, porózus polimer vázszerkezetek előállítására vonatkozik.A találmány szerinti eljárás az alábbi lépésekből áll: (i) egypolimert valamely szerves oldószerben feloldva polimer oldatotkészítenek; (ii) egy pezsegve oldódó sónak a kapott polimer oldatbakeverésével polimer/só/szerves oldószer kevert gélt állítanak elő;(iii) a polimer/ só/szerves oldószer kevert gélből a szerves oldószerteltávolítják; és (iv) a gélt savas oldatba merítve és ezzel a sópezsgését kiváltva polimer vázszerkezetet kapnak. A találmány szerintivázszerkezetek porozitása és pórusok közötti interkonnektivitásaszövetekből izolált sejtek befogadására és tenyésztésére alkalmas. Atalálmány szerinti eljárásnak előnyös, mert a sejttenyészethezalkalmazott mátrix a géllel könnyen a kívánt formára alakítható, és avázszerkezetek porozitása és pórusmérete a pezsegve oldódó sórészecskeméretének és mennyiségének, valamint a sók pezsgését éskilúgozását kiváltó savas vizes oldatok koncentrációjánakszabályozásával beállítható. ÓThe invention relates to the production of three-dimensional, biodegradable and biologically compatible, porous polymer framework structures. The method according to the invention consists of the following steps: (i) a polymer solution is prepared by dissolving a single polymer in an organic solvent; (ii) a polymer/salt/organic solvent mixed gel is produced by mixing an effervescent salt into the resulting polymer solution; (iii) the organic solvent is removed from the polymer/salt/organic solvent mixed gel; and (iv) by immersing the gel in an acid solution and thus causing its salt foaming, a polymeric framework is obtained. The porosity and interconnectivity of the framework structures according to the invention are suitable for receiving and cultivating cells isolated from tissues. The method according to the invention is advantageous because the matrix used for cell culture can be easily shaped into the desired shape with the gel, and the porosity and pore size of framework structures can be adjusted by controlling the size and quantity of the effervescent salt particles and the concentration of the acidic aqueous solutions that cause the effervescence and leaching of the salts. HE

HU0004498A 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold and scaffold prepared there form HUP0004498A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-1999-0050922A KR100372751B1 (en) 1999-11-16 1999-11-16 Fabrication Method of Porous Biodegradable Polymer Scaffolds for Tissue Engineering

Publications (3)

Publication Number Publication Date
HU0004498D0 HU0004498D0 (en) 2001-01-29
HUP0004498A2 true HUP0004498A2 (en) 2001-10-28
HUP0004498A3 HUP0004498A3 (en) 2003-10-28

Family

ID=19620369

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004498A HUP0004498A3 (en) 1999-11-16 2000-11-15 Method for preparing biocompatible scaffold and scaffold prepared there form

Country Status (10)

Country Link
KR (1) KR100372751B1 (en)
CN (1) CN1169948C (en)
AR (1) AR026510A1 (en)
AU (1) AU780321B2 (en)
BR (1) BR0005413B1 (en)
CA (1) CA2326057A1 (en)
HU (1) HUP0004498A3 (en)
IL (1) IL139715A (en)
NZ (1) NZ508148A (en)
SG (1) SG92758A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101491703B (en) * 2001-12-24 2013-02-20 财团法人工业技术研究院 Vitro tissue culturing method and multi-pore carrier
KR100629392B1 (en) * 2002-05-10 2006-09-29 주식회사 리젠 바이오텍 In vitro Spermatogenesis Culture Method Using Scaffold
KR100499096B1 (en) * 2002-09-13 2005-07-01 이진호 Fabrication method of porous polymeric scaffolds for tissue engineering application
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
WO2006063350A2 (en) 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
CN100431622C (en) * 2005-12-08 2008-11-12 东南大学 Method of organizing polymer porous support material for engineering and its preparation device
WO2007107038A1 (en) * 2006-03-20 2007-09-27 Hua Liu Constructing tumor model in vitro and its application
KR100760511B1 (en) * 2006-11-16 2007-10-04 한국과학기술연구원 Preparation method of biodegradable porous polymer scaffolds for tissue engineering using hydrogen peroxide
CN101147810B (en) * 2007-11-01 2010-05-19 南昌大学第一附属医院 Cell-biodegradable material compound and its preparation method and application
KR100963435B1 (en) 2008-06-19 2010-06-17 한국과학기술연구원 Method of preparing biodegradable covered porous polymer microspheres for sustained-release drug delivery and tissue regeneration
KR101003749B1 (en) 2008-09-19 2010-12-23 문형순 Formation Method of porous material using polylactide
JP5851520B2 (en) * 2011-12-01 2016-02-03 富士ソフト株式会社 Long-term preservation method of porous body with chondrocytes attached
RU2015143995A (en) 2013-03-14 2017-04-20 Халлюкс, Инк. METHOD FOR TREATING INFECTIONS, DISEASES OR DISEASES OF THE NAIL LODGE
CN106701570A (en) * 2015-08-18 2017-05-24 重庆润泽医药有限公司 Tissue cell culture device
WO2017099261A1 (en) * 2015-12-07 2017-06-15 주식회사 글로원 Method for preparing scaffold by using salt leaching and immersion precipitation methods, and scaffold thereof
EP3418741A1 (en) * 2017-06-19 2018-12-26 Safeguard Biosystems Holdings Ltd. Three-dimensional polymer networks and their use
CN110947035B (en) * 2019-10-30 2022-04-05 中山大学附属第六医院 Method for modifying surface of P4HB patch in porous manner and P4HB patch
CN114958709B (en) * 2021-12-07 2024-04-19 中科睿极(海宁)生物科技有限公司 Microcarrier aggregate capable of being rapidly disintegrated and preparation method thereof
CN115645609A (en) * 2021-12-30 2023-01-31 盐城工业职业技术学院 Three-dimensional porous biodegradable polymer artificial esophagus stent and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5723508A (en) * 1996-01-25 1998-03-03 Northwestern University Method of fabricating emulsion freeze-dried scaffold bodies and resulting products
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6165486A (en) * 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
KR100288488B1 (en) * 1999-03-18 2001-04-16 윤덕용 Fabrication Method of Porous Polymer Scaffolds for Tissue Engneering by Using a Gas Foaming Salt
ATE368728T1 (en) * 1999-03-18 2007-08-15 Korea Advanced Inst Sci & Tech METHOD FOR PRODUCING POROUS, BIODEGRADABLE AND BIOCOMPATIBLE POLYMER SUPPORTING TISSUES FOR TISSUE TECHNOLOGY
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Also Published As

Publication number Publication date
CA2326057A1 (en) 2001-05-16
KR100372751B1 (en) 2003-02-17
CN1169948C (en) 2004-10-06
NZ508148A (en) 2002-05-31
BR0005413A (en) 2001-08-07
KR20010046941A (en) 2001-06-15
SG92758A1 (en) 2002-11-19
CN1297042A (en) 2001-05-30
HUP0004498A3 (en) 2003-10-28
HU0004498D0 (en) 2001-01-29
BR0005413B1 (en) 2012-08-07
IL139715A0 (en) 2002-02-10
AU780321B2 (en) 2005-03-17
AR026510A1 (en) 2003-02-12
IL139715A (en) 2006-06-11
AU7160000A (en) 2001-05-17

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