AR026510A1 - METHOD FOR PREPARING A BIOCOMPATIBLE AND BIODEGRADABLE POROUS POLYMER SUPPORT AND SUPPORT PREPARED BY SUCH METHOD - Google Patents

METHOD FOR PREPARING A BIOCOMPATIBLE AND BIODEGRADABLE POROUS POLYMER SUPPORT AND SUPPORT PREPARED BY SUCH METHOD

Info

Publication number
AR026510A1
AR026510A1 ARP000106064A ARP000106064A AR026510A1 AR 026510 A1 AR026510 A1 AR 026510A1 AR P000106064 A ARP000106064 A AR P000106064A AR P000106064 A ARP000106064 A AR P000106064A AR 026510 A1 AR026510 A1 AR 026510A1
Authority
AR
Argentina
Prior art keywords
salt
support
polymer
preparing
biocompatible
Prior art date
Application number
ARP000106064A
Other languages
Spanish (es)
Original Assignee
Innotech Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innotech Medical Inc filed Critical Innotech Medical Inc
Publication of AR026510A1 publication Critical patent/AR026510A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/0014—Use of organic additives
    • C08J9/0023—Use of organic additives containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Un método para preparar soportes poliméricos, porosos, tridimensionales, biodegradables y biocompatibles destinados a la ingeniería de tejidos, quecomprende los pasos de: (i) disolver un polímero en un solvente orgánico para preparar una solucion pol imérica; (ii) mezclar una sal efervescente con lasolucion polimérica resulltante para obtener un gel mixto compuesto por el polimero, la sal y el solvente orgánico; y (iv) hacer que la sal entre enefervescencia en el gel mixto resultante compuesto po r el polímero y la sal para obtener un soporte polimérico. La porosidad y las interconexiones entre losporos que presenta el soporte permiten alojar cultivos celulares aislados de los tejidos que se habrán de cultivar, El método de esta invencion of rece variasventajas: (i) permite dar facilmente la forma deseada a la matriz de cultivos de células con el gel y (ii) controlar el tamano del poro y la porosidad delsoporte polimérico poroso tridimensional controlando la cantidad y el tamano de las s ales efervescentes y la concentracion de las soluciones acuosas ácidasmediante las cules se induce la efervescencia y la lixividacion de las sales.A method for preparing polymeric, porous, three-dimensional, biodegradable and biocompatible supports intended for tissue engineering, comprising the steps of: (i) dissolving a polymer in an organic solvent to prepare a polymer solution; (ii) mixing an effervescent salt with the resulting polymer solution to obtain a mixed gel composed of the polymer, the salt and the organic solvent; and (iv) make the salt between effervescence in the resulting mixed gel composed of the polymer and the salt to obtain a polymeric support. The porosity and the interconnections between the pores that the support presents allow housing cell cultures isolated from the tissues to be cultured. The method of this invention offers several advantages: (i) it allows to easily give the desired shape to the cell culture matrix with the gel and (ii) control the size of the pore and the porosity of the three-dimensional porous polymeric support by controlling the amount and size of the effervescent signals and the concentration of the acidic aqueous solutions through which the effervescence and leaching of the salts is induced .

ARP000106064A 1999-11-16 2000-11-16 METHOD FOR PREPARING A BIOCOMPATIBLE AND BIODEGRADABLE POROUS POLYMER SUPPORT AND SUPPORT PREPARED BY SUCH METHOD AR026510A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-1999-0050922A KR100372751B1 (en) 1999-11-16 1999-11-16 Fabrication Method of Porous Biodegradable Polymer Scaffolds for Tissue Engineering

Publications (1)

Publication Number Publication Date
AR026510A1 true AR026510A1 (en) 2003-02-12

Family

ID=19620369

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000106064A AR026510A1 (en) 1999-11-16 2000-11-16 METHOD FOR PREPARING A BIOCOMPATIBLE AND BIODEGRADABLE POROUS POLYMER SUPPORT AND SUPPORT PREPARED BY SUCH METHOD

Country Status (10)

Country Link
KR (1) KR100372751B1 (en)
CN (1) CN1169948C (en)
AR (1) AR026510A1 (en)
AU (1) AU780321B2 (en)
BR (1) BR0005413B1 (en)
CA (1) CA2326057A1 (en)
HU (1) HUP0004498A3 (en)
IL (1) IL139715A (en)
NZ (1) NZ508148A (en)
SG (1) SG92758A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101491703B (en) * 2001-12-24 2013-02-20 财团法人工业技术研究院 Vitro tissue culturing method and multi-pore carrier
KR100629392B1 (en) * 2002-05-10 2006-09-29 주식회사 리젠 바이오텍 In vitro Spermatogenesis Culture Method Using Scaffold
KR100499096B1 (en) * 2002-09-13 2005-07-01 이진호 Fabrication method of porous polymeric scaffolds for tissue engineering application
US20060275230A1 (en) 2004-12-10 2006-12-07 Frank Kochinke Compositions and methods for treating conditions of the nail unit
WO2006063350A2 (en) 2004-12-10 2006-06-15 Talima Therapeutics, Inc. Compositions and methods for treating conditions of the nail unit
CN100431622C (en) * 2005-12-08 2008-11-12 东南大学 Method of organizing polymer porous support material for engineering and its preparation device
WO2007107038A1 (en) * 2006-03-20 2007-09-27 Hua Liu Constructing tumor model in vitro and its application
KR100760511B1 (en) * 2006-11-16 2007-10-04 한국과학기술연구원 Preparation method of biodegradable porous polymer scaffolds for tissue engineering using hydrogen peroxide
CN101147810B (en) * 2007-11-01 2010-05-19 南昌大学第一附属医院 Cell-biodegradable material compound and its preparation method and application
KR100963435B1 (en) 2008-06-19 2010-06-17 한국과학기술연구원 Method of preparing biodegradable covered porous polymer microspheres for sustained-release drug delivery and tissue regeneration
KR101003749B1 (en) 2008-09-19 2010-12-23 문형순 Formation Method of porous material using polylactide
JP5851520B2 (en) * 2011-12-01 2016-02-03 富士ソフト株式会社 Long-term preservation method of porous body with chondrocytes attached
RU2015143995A (en) 2013-03-14 2017-04-20 Халлюкс, Инк. METHOD FOR TREATING INFECTIONS, DISEASES OR DISEASES OF THE NAIL LODGE
CN106701570A (en) * 2015-08-18 2017-05-24 重庆润泽医药有限公司 Tissue cell culture device
WO2017099261A1 (en) * 2015-12-07 2017-06-15 주식회사 글로원 Method for preparing scaffold by using salt leaching and immersion precipitation methods, and scaffold thereof
EP3418741A1 (en) * 2017-06-19 2018-12-26 Safeguard Biosystems Holdings Ltd. Three-dimensional polymer networks and their use
CN110947035B (en) * 2019-10-30 2022-04-05 中山大学附属第六医院 Method for modifying surface of P4HB patch in porous manner and P4HB patch
CN114958709B (en) * 2021-12-07 2024-04-19 中科睿极(海宁)生物科技有限公司 Microcarrier aggregate capable of being rapidly disintegrated and preparation method thereof
CN115645609A (en) * 2021-12-30 2023-01-31 盐城工业职业技术学院 Three-dimensional porous biodegradable polymer artificial esophagus stent and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5723508A (en) * 1996-01-25 1998-03-03 Northwestern University Method of fabricating emulsion freeze-dried scaffold bodies and resulting products
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6165486A (en) * 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
KR100288488B1 (en) * 1999-03-18 2001-04-16 윤덕용 Fabrication Method of Porous Polymer Scaffolds for Tissue Engneering by Using a Gas Foaming Salt
ATE368728T1 (en) * 1999-03-18 2007-08-15 Korea Advanced Inst Sci & Tech METHOD FOR PRODUCING POROUS, BIODEGRADABLE AND BIOCOMPATIBLE POLYMER SUPPORTING TISSUES FOR TISSUE TECHNOLOGY
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering

Also Published As

Publication number Publication date
CA2326057A1 (en) 2001-05-16
KR100372751B1 (en) 2003-02-17
CN1169948C (en) 2004-10-06
NZ508148A (en) 2002-05-31
BR0005413A (en) 2001-08-07
HUP0004498A2 (en) 2001-10-28
KR20010046941A (en) 2001-06-15
SG92758A1 (en) 2002-11-19
CN1297042A (en) 2001-05-30
HUP0004498A3 (en) 2003-10-28
HU0004498D0 (en) 2001-01-29
BR0005413B1 (en) 2012-08-07
IL139715A0 (en) 2002-02-10
AU780321B2 (en) 2005-03-17
IL139715A (en) 2006-06-11
AU7160000A (en) 2001-05-17

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