HUP0004274A2 - Bispyrido-cycloheptane compounds and pharmaceutical compositions thereof - Google Patents
Bispyrido-cycloheptane compounds and pharmaceutical compositions thereofInfo
- Publication number
- HUP0004274A2 HUP0004274A2 HU0004274A HUP0004274A HUP0004274A2 HU P0004274 A2 HUP0004274 A2 HU P0004274A2 HU 0004274 A HU0004274 A HU 0004274A HU P0004274 A HUP0004274 A HU P0004274A HU P0004274 A2 HUP0004274 A2 HU P0004274A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- hydrogen
- bispyrido
- pharmaceutical compositions
- formula
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 125000004350 aryl cycloalkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- JSPCTNUQYWIIOT-UHFFFAOYSA-N piperidine-1-carboxamide Chemical compound NC(=O)N1CCCCC1 JSPCTNUQYWIIOT-UHFFFAOYSA-N 0.000 abstract 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
- LCDCPQHFCOBUEF-UHFFFAOYSA-N pyrrolidine-1-carboxamide Chemical compound NC(=O)N1CCCC1 LCDCPQHFCOBUEF-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát (1.0) és (2.0) általános képletű, farnezil-protein-transzferáz inhibitor hatású új vegyületek - ahol a szaggatottvonal adott esetben jelen levő kettős kötést jelent, és előnyösen A ésB hidrogén- vagy halogénatom vagy metilcsoport; R5, R6, R7 és R8hidrogénatom, trifluor-metil-, alkil-, aril-cikloalkil- vagyheterocikloalkilcsoport, de különösen előnyösen hidrogénatom; és R -C(O)R1 általános képletű csoport, amelyben R1 - (CH2)n-RA általánosképletű csoportot jelent, ahol RA aril-, cikloalkil- vagyheterocikloalkilcsoport, de különösen piridin-N-oxidból, N-karbamoil-piperidinből vagy N-karbamoil-pirrolidinből származtatható csoport -és sóik, ezeket tartalmazó gyógyszerkészítmények képezik, amelyektumorok kezelésére vagy antiallergiás szerként alkalmazhatók. ÓThe subject of the invention are new farnesyl-protein transferase inhibitory compounds of formulas (1.0) and (2.0) - where the dashed line means a double bond that may be present, and preferably A and B are hydrogen or halogen atoms or methyl groups; R 5 , R 6 , R 7 and R 8 are hydrogen, trifluoromethyl, alkyl, arylcycloalkyl or heterocycloalkyl, but particularly preferably hydrogen; and a group of formula R -C(O)R1, in which R1 is a group of formula - (CH2)n-RA, where RA is an aryl, cycloalkyl or heterocycloalkyl group, but especially from pyridine N-oxide, N-carbamoylpiperidine or N- a group derivable from carbamoyl-pyrrolidine - and their salts, forming pharmaceutical preparations containing them, which can be used for the treatment of tumors or as anti-allergic agents. HE
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87774397A | 1997-06-17 | 1997-06-17 | |
| PCT/US1998/011496 WO1998057961A1 (en) | 1997-06-17 | 1998-06-15 | Bispyrido-cycloheptane compounds useful for inhibition of farnesyl protein transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004274A2 true HUP0004274A2 (en) | 2001-08-28 |
| HUP0004274A3 HUP0004274A3 (en) | 2002-03-28 |
Family
ID=25370623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004274A HUP0004274A3 (en) | 1997-06-17 | 1998-06-15 | Bispyrido-cycloheptane compounds and pharmaceutical compositions thereof |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0989984A1 (en) |
| JP (1) | JP2002504145A (en) |
| KR (1) | KR20010013825A (en) |
| CN (1) | CN1266432A (en) |
| AR (1) | AR015122A1 (en) |
| AU (1) | AU744153B2 (en) |
| CA (1) | CA2293713C (en) |
| CO (1) | CO4940447A1 (en) |
| HU (1) | HUP0004274A3 (en) |
| IL (1) | IL133388A0 (en) |
| NZ (1) | NZ501418A (en) |
| WO (1) | WO1998057961A1 (en) |
| ZA (1) | ZA985214B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010256360A1 (en) | 2009-06-05 | 2012-01-12 | Astrazeneca Ab | Aminopyrrolidinone derivatives and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5719148A (en) * | 1993-10-15 | 1998-02-17 | Schering Corporation | Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| JP2875393B2 (en) * | 1993-10-15 | 1999-03-31 | シェーリング コーポレイション | Tricyclic carbamate compounds useful for inhibiting G-protein function and treating proliferative disorders |
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them |
| SK86198A3 (en) * | 1995-12-22 | 1999-02-11 | Schering Corp | Tricyclic amides useful for inhibition of g-protein function and for treatment of proliferative diseases |
-
1998
- 1998-06-15 WO PCT/US1998/011496 patent/WO1998057961A1/en not_active Application Discontinuation
- 1998-06-15 KR KR1019997011845A patent/KR20010013825A/en not_active Application Discontinuation
- 1998-06-15 CA CA002293713A patent/CA2293713C/en not_active Expired - Fee Related
- 1998-06-15 HU HU0004274A patent/HUP0004274A3/en unknown
- 1998-06-15 JP JP50449199A patent/JP2002504145A/en not_active Ceased
- 1998-06-15 EP EP98928887A patent/EP0989984A1/en not_active Withdrawn
- 1998-06-15 CN CN98808118A patent/CN1266432A/en active Pending
- 1998-06-15 IL IL13338898A patent/IL133388A0/en unknown
- 1998-06-15 AU AU80581/98A patent/AU744153B2/en not_active Ceased
- 1998-06-15 ZA ZA985214A patent/ZA985214B/en unknown
- 1998-06-15 NZ NZ501418A patent/NZ501418A/en unknown
- 1998-06-16 CO CO98034143A patent/CO4940447A1/en unknown
- 1998-06-16 AR ARP980102863A patent/AR015122A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010013825A (en) | 2001-02-26 |
| NZ501418A (en) | 2001-04-27 |
| CA2293713A1 (en) | 1998-12-23 |
| WO1998057961A1 (en) | 1998-12-23 |
| AU8058198A (en) | 1999-01-04 |
| AR015122A1 (en) | 2001-04-18 |
| HUP0004274A3 (en) | 2002-03-28 |
| JP2002504145A (en) | 2002-02-05 |
| AU744153B2 (en) | 2002-02-14 |
| IL133388A0 (en) | 2001-04-30 |
| EP0989984A1 (en) | 2000-04-05 |
| ZA985214B (en) | 1999-01-07 |
| CA2293713C (en) | 2006-12-05 |
| CO4940447A1 (en) | 2000-07-24 |
| CN1266432A (en) | 2000-09-13 |
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