HUP0002207A2 - Cell cycle checkpoint pik-related kinase materials and methods - Google Patents
Cell cycle checkpoint pik-related kinase materials and methodsInfo
- Publication number
- HUP0002207A2 HUP0002207A2 HU0002207A HUP0002207A HUP0002207A2 HU P0002207 A2 HUP0002207 A2 HU P0002207A2 HU 0002207 A HU0002207 A HU 0002207A HU P0002207 A HUP0002207 A HU P0002207A HU P0002207 A2 HUP0002207 A2 HU P0002207A2
- Authority
- HU
- Hungary
- Prior art keywords
- kinase
- mccs
- pik
- cell cycle
- methods
- Prior art date
Links
- 102000016563 PIK-related kinases Human genes 0.000 title 1
- 108050006107 PIK-related kinases Proteins 0.000 title 1
- 230000012820 cell cycle checkpoint Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 3
- 102000017343 Phosphatidylinositol kinases Human genes 0.000 abstract 3
- 108050005377 Phosphatidylinositol kinases Proteins 0.000 abstract 3
- 108091000080 Phosphotransferase Proteins 0.000 abstract 3
- 102000020233 phosphotransferase Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000000872 ATM Human genes 0.000 abstract 1
- 101150065175 Atm gene Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000022131 cell cycle Effects 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Abstract
Purified and isolated polynucleotides encoding phosphatidylinositol kinase (PIK)-related mammalian cell cycle surveillance 1 (MCCS1)-alpha and -beta having the 2410 and 2480 amino acid respectively are new. All the sequences are given in the specification. Also claimed are: (1) RNA transcripts of the above polynucleotides; (2) DNA encoding full length mammalian MCCS 1 kinase selected from DNA hybridising to the 7624 or 7502 bp sequences as above or to the 2835 bp sequence given in the specification; (3) vectors comprising the polynucleotides; (4) host cells stably transformed or transfected with the DNAs, such that the cells express MCCS 1 kinase; (5) the purified MSSC1alpha and -beta proteins; (6) a (poly)peptide, preferably a monoclonal antibody (MAb), which binds specifically to the PIK-related MCCS 1; (7) a hybridoma producing the MAbs of (6); and (8) methods of identifying modulators or inhibitors of MCCS kinase or Ataxia-Telangiectasia Mutated (ATM) kinase activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72530496A | 1996-10-21 | 1996-10-21 | |
| PCT/US1996/019337 WO1997018323A2 (en) | 1995-11-16 | 1996-11-18 | Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0002207A2 true HUP0002207A2 (en) | 2000-09-28 |
Family
ID=24913997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002207A HUP0002207A2 (en) | 1996-10-21 | 1996-11-18 | Cell cycle checkpoint pik-related kinase materials and methods |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUP0002207A2 (en) |
-
1996
- 1996-11-18 HU HU0002207A patent/HUP0002207A2/en unknown
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