HUP0000552A2 - O-(3-piperidino-2-hydroxy-1-propyl)-hydroxymic acid halogenide derivative, its use and medicament containing it - Google Patents
O-(3-piperidino-2-hydroxy-1-propyl)-hydroxymic acid halogenide derivative, its use and medicament containing itInfo
- Publication number
- HUP0000552A2 HUP0000552A2 HU0000552A HUP0000552A HUP0000552A2 HU P0000552 A2 HUP0000552 A2 HU P0000552A2 HU 0000552 A HU0000552 A HU 0000552A HU P0000552 A HUP0000552 A HU P0000552A HU P0000552 A2 HUP0000552 A2 HU P0000552A2
- Authority
- HU
- Hungary
- Prior art keywords
- hydroxy
- treatment
- piperidino
- propyl
- insulin
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 230000001575 pathological effect Effects 0.000 abstract 4
- 239000000654 additive Substances 0.000 abstract 3
- 230000000996 additive effect Effects 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000012876 carrier material Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Abstract
N-(2-hydroxy-3-(1-piperidinil-)-propoxy)-piridin-1-oxyde-3- carboxymidoil-chloride, its stereo isomers, or acid additive salts, are new. Further, the proposal refers to the use of the above compounds for overcoming pathological resistance to insulin, and to methods of treatment for related conditions, and to the treatment of insulin resistance and related pathological conditions. N-(2-hydroxy-3-(1-piperidinil-)-propoxy)-piridin-1-oxyde-3- carboxymidoil-chloride, its stereo isomers, or acid additive salts, are new. Further, the proposal refers to the use of the above compounds for overcoming pathological resistance to insulin, and to methods of treatment for related conditions, and to the treatment of insulin resistance and related pathological conditions. Also referred to are pharmaceutical preparations containing the above as the active ingredient, with established additive and carrier materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0000552A HU227343B1 (en) | 2000-02-08 | 2000-02-08 | O-(3-piperidino-2-hydroxy-1-propyl)-hydroxymic acid halogenide derivative, its use and medicament containing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0000552A HU227343B1 (en) | 2000-02-08 | 2000-02-08 | O-(3-piperidino-2-hydroxy-1-propyl)-hydroxymic acid halogenide derivative, its use and medicament containing it |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU0000552D0 HU0000552D0 (en) | 2000-04-28 |
| HUP0000552A2 true HUP0000552A2 (en) | 2001-12-28 |
| HU227343B1 HU227343B1 (en) | 2011-04-28 |
Family
ID=89978080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000552A HU227343B1 (en) | 2000-02-08 | 2000-02-08 | O-(3-piperidino-2-hydroxy-1-propyl)-hydroxymic acid halogenide derivative, its use and medicament containing it |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HU227343B1 (en) |
-
2000
- 2000-02-08 HU HU0000552A patent/HU227343B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU0000552D0 (en) | 2000-04-28 |
| HU227343B1 (en) | 2011-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: CYTRX CORPORATION, US Free format text: FORMER OWNER(S): BIOREX KUTATO ES FEJLESZTOE RT., HU |
|
| GB9A | Succession in title |
Owner name: ORPHAZYME APS, DK Free format text: FORMER OWNER(S): BIOREX KUTATO ES FEJLESZTOE RT., HU; CYTRX CORPORATION, US |
|
| GB9A | Succession in title |
Owner name: ORPHAZYME A/S, DK Free format text: FORMER OWNER(S): BIOREX KUTATO ES FEJLESZTOE RT., HU; CYTRX CORPORATION, US; ORPHAZYME APS, DK |