HUE051196T2 - Process for preparation of nitrogen mustard derivatives - Google Patents
Process for preparation of nitrogen mustard derivativesInfo
- Publication number
- HUE051196T2 HUE051196T2 HUE16722854A HUE16722854A HUE051196T2 HU E051196 T2 HUE051196 T2 HU E051196T2 HU E16722854 A HUE16722854 A HU E16722854A HU E16722854 A HUE16722854 A HU E16722854A HU E051196 T2 HUE051196 T2 HU E051196T2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- nitrogen mustard
- mustard derivatives
- derivatives
- nitrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/14—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1507903.1A GB201507903D0 (en) | 2015-05-08 | 2015-05-08 | Process for preparation of nitrogen mustard derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE051196T2 true HUE051196T2 (en) | 2021-03-01 |
Family
ID=53489337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16722854A HUE051196T2 (en) | 2015-05-08 | 2016-05-06 | Process for preparation of nitrogen mustard derivatives |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10287316B2 (en) |
| EP (1) | EP3280721B1 (en) |
| JP (1) | JP6862354B2 (en) |
| KR (1) | KR102593509B1 (en) |
| CN (1) | CN107810189B (en) |
| AU (1) | AU2016260693B2 (en) |
| BR (1) | BR112017024051A2 (en) |
| CA (1) | CA2983559C (en) |
| CY (1) | CY1123468T1 (en) |
| ES (1) | ES2826401T3 (en) |
| GB (1) | GB201507903D0 (en) |
| HK (1) | HK1250732A1 (en) |
| HR (1) | HRP20201616T1 (en) |
| HU (1) | HUE051196T2 (en) |
| IL (1) | IL255428B (en) |
| LT (1) | LT3280721T (en) |
| MX (1) | MX2017014292A (en) |
| PL (1) | PL3280721T3 (en) |
| PT (1) | PT3280721T (en) |
| RS (1) | RS60952B1 (en) |
| RU (1) | RU2715233C2 (en) |
| SI (1) | SI3280721T1 (en) |
| WO (1) | WO2016180740A1 (en) |
| ZA (1) | ZA201707226B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210388024A1 (en) * | 2018-10-18 | 2021-12-16 | Oncopeptides Ab | Compounds containing deuterium |
| JP2021120362A (en) * | 2020-01-30 | 2021-08-19 | 公立大学法人大阪 | Nitrogen-containing compound, method for manufacturing the same, and optical functional material including the same |
| CN112546969B (en) * | 2020-12-07 | 2022-12-23 | 安徽贝克制药股份有限公司 | Catalytic hydrogenation continuous production device and preparation method of ritonavir intermediate |
| WO2022253894A1 (en) | 2021-06-01 | 2022-12-08 | Synthon B.V. | Process for making melflufen or a salt thereof |
| GB202204171D0 (en) | 2022-03-24 | 2022-05-11 | Oncopeptides Ab | Novel formulations |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0002202D0 (en) * | 2000-06-13 | 2000-06-13 | Karolinska Innovations Ab | New peptides |
| DE60141398D1 (en) * | 2000-06-13 | 2010-04-08 | Oncopeptides Ab | MELPHALAN DERIVATIVES AND THEIR USE AS CHEMOTHERAPEUTICS AGAINST CANCER |
| ES2400070T3 (en) * | 2001-12-03 | 2013-04-05 | Bayer Healthcare Llc | Aryl urea compounds in combination with other cytostatic or cytotoxic agents for the treatment of human cancers |
| TW200615273A (en) * | 2004-11-10 | 2006-05-16 | Nicholas Piramal India Ltd | Fused tricyclic compounds as inhibitors of tumor necrosis factor-alpha |
| CN101300255A (en) * | 2005-05-20 | 2008-11-05 | 艾伦药物公司 | Imidazolone phenylalanine derivatives as VLA-4 antagonists |
| CN100491339C (en) | 2007-04-20 | 2009-05-27 | 苏州市立德化学有限公司 | Technique for synthesizing antineoplastic melphalan |
| WO2010042568A1 (en) * | 2008-10-08 | 2010-04-15 | Cephalon, Inc. | Processes for the preparation of bendamustine |
| DK3228319T3 (en) | 2011-04-28 | 2020-09-07 | Oncopeptides Ab | Lyophilized preparation of cytotoxic dipeptides |
| US20130079383A1 (en) * | 2011-07-13 | 2013-03-28 | Arrowhead Research Corporation | Lipid Compounds Targeting VLA-4 |
| JP6284945B2 (en) | 2012-10-26 | 2018-02-28 | オンコペプティデス エービーＯｎｃｏｐｅｐｔｉｄｅｓ ＡＢ | Freeze-dried melphalan flufenamide |
| US9963422B2 (en) * | 2013-03-11 | 2018-05-08 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of melphalan and the hydrochloride salt |
| ITMI20130896A1 (en) * | 2013-05-31 | 2014-12-01 | Farmabios Spa | MELPHALAN PURIFICATION PROCESS |
-
2015
- 2015-05-08 GB GBGB1507903.1A patent/GB201507903D0/en not_active Ceased
-
2016
- 2016-05-06 RU RU2017142725A patent/RU2715233C2/en active
- 2016-05-06 US US15/572,300 patent/US10287316B2/en active Active
- 2016-05-06 BR BR112017024051-3A patent/BR112017024051A2/en active Search and Examination
- 2016-05-06 CA CA2983559A patent/CA2983559C/en active Active
- 2016-05-06 AU AU2016260693A patent/AU2016260693B2/en active Active
- 2016-05-06 JP JP2017558492A patent/JP6862354B2/en active Active
- 2016-05-06 HU HUE16722854A patent/HUE051196T2/en unknown
- 2016-05-06 EP EP16722854.3A patent/EP3280721B1/en active Active
- 2016-05-06 RS RS20201255A patent/RS60952B1/en unknown
- 2016-05-06 MX MX2017014292A patent/MX2017014292A/en unknown
- 2016-05-06 KR KR1020177035258A patent/KR102593509B1/en active IP Right Grant
- 2016-05-06 PL PL16722854T patent/PL3280721T3/en unknown
- 2016-05-06 SI SI201630942T patent/SI3280721T1/en unknown
- 2016-05-06 PT PT167228543T patent/PT3280721T/en unknown
- 2016-05-06 WO PCT/EP2016/060242 patent/WO2016180740A1/en active Application Filing
- 2016-05-06 LT LTEP16722854.3T patent/LT3280721T/en unknown
- 2016-05-06 CN CN201680026550.8A patent/CN107810189B/en active Active
- 2016-05-06 ES ES16722854T patent/ES2826401T3/en active Active
-
2017
- 2017-10-24 ZA ZA2017/07226A patent/ZA201707226B/en unknown
- 2017-11-05 IL IL255428A patent/IL255428B/en unknown
-
2018
- 2018-08-08 HK HK18110180.9A patent/HK1250732A1/en unknown
-
2020
- 2020-10-08 HR HRP20201616TT patent/HRP20201616T1/en unknown
- 2020-10-13 CY CY20201100964T patent/CY1123468T1/en unknown
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