HUE039970T2 - Pirazolopiridazinok és eljárás degeneratív retina betegségek és Usher-szindrómával összefüggõ hallásvesztés kezelésére - Google Patents
Pirazolopiridazinok és eljárás degeneratív retina betegségek és Usher-szindrómával összefüggõ hallásvesztés kezeléséreInfo
- Publication number
- HUE039970T2 HUE039970T2 HUE13848995A HUE13848995A HUE039970T2 HU E039970 T2 HUE039970 T2 HU E039970T2 HU E13848995 A HUE13848995 A HU E13848995A HU E13848995 A HUE13848995 A HU E13848995A HU E039970 T2 HUE039970 T2 HU E039970T2
- Authority
- HU
- Hungary
- Prior art keywords
- pyrazolopyridazines
- methods
- hearing loss
- degenerative diseases
- loss associated
- Prior art date
Links
- NMEPLWZDUIIAAC-UHFFFAOYSA-N 1h-pyrazolo[4,3-c]pyridazine Chemical class C1=NN=C2C=NNC2=C1 NMEPLWZDUIIAAC-UHFFFAOYSA-N 0.000 title 1
- 206010011878 Deafness Diseases 0.000 title 1
- 208000014769 Usher Syndromes Diseases 0.000 title 1
- 230000010370 hearing loss Effects 0.000 title 1
- 231100000888 hearing loss Toxicity 0.000 title 1
- 208000016354 hearing loss disease Diseases 0.000 title 1
- 208000015122 neurodegenerative disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718611P | 2012-10-25 | 2012-10-25 | |
| US201361775402P | 2013-03-08 | 2013-03-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039970T2 true HUE039970T2 (hu) | 2019-02-28 |
Family
ID=50545356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13848995A HUE039970T2 (hu) | 2012-10-25 | 2013-10-25 | Pirazolopiridazinok és eljárás degeneratív retina betegségek és Usher-szindrómával összefüggõ hallásvesztés kezelésére |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2911671B1 (https=) |
| JP (1) | JP6291502B2 (https=) |
| AU (1) | AU2013334139B2 (https=) |
| CA (1) | CA2889494C (https=) |
| ES (1) | ES2687854T3 (https=) |
| HU (1) | HUE039970T2 (https=) |
| IL (1) | IL238288B (https=) |
| PL (1) | PL2911671T3 (https=) |
| WO (1) | WO2014066836A1 (https=) |
| ZA (1) | ZA201502655B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2701510T3 (pl) | 2011-04-25 | 2017-07-31 | Usher Iii Initiative Inc | Pirazolopirydazyny oraz sposoby leczenia zwyrodnieniowych chorób siatkówki i utraty słuchu związanych z zespołem ushera |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| CA2889537C (en) * | 2012-10-25 | 2017-12-12 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| WO2017045955A1 (en) * | 2015-09-14 | 2017-03-23 | Basf Se | Heterobicyclic compounds |
| US11407753B2 (en) | 2017-06-05 | 2022-08-09 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| PL3814357T3 (pl) * | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| EP3814345B8 (en) | 2018-06-27 | 2024-10-30 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| WO2020161208A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020161209A1 (en) | 2019-02-06 | 2020-08-13 | Syngenta Crop Protection Ag | Herbicidal fused pyridazine compounds |
| WO2020231977A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| EP4178580B1 (en) | 2020-07-09 | 2025-11-05 | Usher III Initiative, Inc. | Bf 844 for use in the treatment of cancer |
| WO2023139091A1 (en) * | 2022-01-19 | 2023-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Geralexin and uses thereof for the treatment of retinal degenerative diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0206723D0 (en) * | 2002-03-21 | 2002-05-01 | Glaxo Group Ltd | Novel compounds |
| US20090306045A1 (en) * | 2005-12-22 | 2009-12-10 | Ira Mellman | Inhibition of Glycogen Synthase Kinase and Methods of Treating Autoimmune or Immune Inflammatory Disease |
| CA2705303A1 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| PL2701510T3 (pl) * | 2011-04-25 | 2017-07-31 | Usher Iii Initiative Inc | Pirazolopirydazyny oraz sposoby leczenia zwyrodnieniowych chorób siatkówki i utraty słuchu związanych z zespołem ushera |
| CA2889537C (en) * | 2012-10-25 | 2017-12-12 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
-
2013
- 2013-10-25 HU HUE13848995A patent/HUE039970T2/hu unknown
- 2013-10-25 CA CA2889494A patent/CA2889494C/en active Active
- 2013-10-25 JP JP2015539868A patent/JP6291502B2/ja active Active
- 2013-10-25 EP EP13848995.0A patent/EP2911671B1/en active Active
- 2013-10-25 PL PL13848995T patent/PL2911671T3/pl unknown
- 2013-10-25 WO PCT/US2013/066939 patent/WO2014066836A1/en not_active Ceased
- 2013-10-25 ES ES13848995.0T patent/ES2687854T3/es active Active
- 2013-10-25 AU AU2013334139A patent/AU2013334139B2/en active Active
-
2015
- 2015-04-14 IL IL238288A patent/IL238288B/en active IP Right Grant
- 2015-04-20 ZA ZA2015/02655A patent/ZA201502655B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL238288B (en) | 2018-04-30 |
| ZA201502655B (en) | 2017-11-29 |
| CA2889494C (en) | 2018-12-18 |
| PL2911671T3 (pl) | 2018-11-30 |
| EP2911671A4 (en) | 2016-09-14 |
| CA2889494A1 (en) | 2014-05-01 |
| JP2015535257A (ja) | 2015-12-10 |
| EP2911671B1 (en) | 2018-06-27 |
| ES2687854T3 (es) | 2018-10-29 |
| HK1214180A1 (en) | 2016-07-22 |
| EP2911671A1 (en) | 2015-09-02 |
| JP6291502B2 (ja) | 2018-03-14 |
| AU2013334139A1 (en) | 2015-04-30 |
| WO2014066836A1 (en) | 2014-05-01 |
| AU2013334139B2 (en) | 2017-08-03 |
| IL238288A0 (en) | 2015-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201502655B (en) | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome | |
| GB2500915B (en) | Arrangement and method | |
| ZA201507790B (en) | Enhanced adoptive cell therapy | |
| ZA201504401B (en) | Filter arrangements; components; assemblies; and, methods | |
| SG10201609812SA (en) | System and process for retina phototherapy | |
| TWI561481B (en) | Glass manufacturing apparatus and methods | |
| EP2856994A4 (en) | ABSORBENT ARTICLE AND MANUFACTURING METHOD THEREFOR | |
| DK3292875T3 (en) | Compositions and methods for treating diseases | |
| ZA201307961B (en) | Pyrazolopyridazines and methods for treating retinal-degenarative diseases and hearing loss associated with usher syndrome | |
| GB201216649D0 (en) | Agents and methods | |
| EP2907494A4 (en) | TABLE FOR WHEELCHAIR AND WHEELCHAIR COMPRISING THE SAME | |
| EP2934412A4 (en) | LAMINATE AND METHOD FOR THE MANUFACTURE THEREOF | |
| GB201217070D0 (en) | Airflow modification patch and method | |
| GB201310158D0 (en) | Medico-surgical assemblies and means | |
| ZA201502654B (en) | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome | |
| GB2504303B (en) | Earphones and earplugs | |
| SG11201500047QA (en) | Vacuum forming process and use | |
| GB201213782D0 (en) | Process and dressing | |
| EP2809285A4 (en) | HYPERBARE CHAMBER SYSTEM AND ASSOCIATED METHODS | |
| GB201221092D0 (en) | Assemblies and methods | |
| GB201213778D0 (en) | Process and dressng | |
| SG11201501838RA (en) | Completion assembly and methods for use thereof | |
| GB201222736D0 (en) | Composition and process | |
| GB2519994B (en) | Assemblies and methods | |
| GB201211961D0 (en) | Methods and groups |